Publications by authors named "Shuaixing Zhuang"
Article Synopsis
- A study investigated how Huangqin Tang (HQT) affects the TLR4/Myd88 signaling pathway and cytokines in rats with ulcerative colitis (UC).
- UC was induced in rats using a combination of chemicals, and they were divided into several groups for treatment.
- Results showed that high-dose HQT significantly improved inflammatory markers and protein expressions related to UC, suggesting HQT may work by inhibiting the TLR4/MyD88/NF-κB pathway and reducing specific inflammatory substances.
The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang (HQT, a traditional Chinese medicine formula). In this study, we used a combinative method approach consisting of chromatographic fingerprinting (high performance liquid chromatography; HPLC), quantitative methods and a pharmacodynamic evaluation model to analyze the flavonoids of HQT obtained from different sources.
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- Researchers developed a simple and selective HPLC method to simultaneously analyze anthraquinones, lignans, and flavonoids in three traditional herbal formulas: XCQT, HPSWT, and HPDHT.
- The method involved using a specific column and mobile phase, achieving high precision (less than 5%) and strong recovery rates (94.28%-99.89%), and successfully validated for various parameters.
- Results showed differences in the content of compounds among the formulas, with XCQT having the highest levels of anthraquinones and flavonoids, while HPSWT had the most lignans, supporting the method's effectiveness for quality control in herbal medicine.
To investigate the effect of huangqin tang on expression of cytokines and NF-κB p65 in rats with ulcerative colitis (UC), and to probe into its underlying mechanisms of action. The mode of UC rats with cell immunoreactivity was made using compound method (trinitrobenzene sulfonic acid and ethanol). Rats were randomly divided into control group, model group, SASP group and high dose, middle dose and low dose of huangqin tang group.
View Article and Find Full Text PDFThe pharmacodynamic (PD) and pharmacokinetic (PK) properties of Huangqin Tang (HQT) were investigated in yeast-induced febrile rats. Blood sample and rectal temperature data of the rats were collected at different times after single oral administration of HQT at 20 g x kg(-1). The plasma concentrations of paeoniflorin, baicalin, wogonoside, baicalein, wogonin, oroxylin A, glycyrrhizic acid and glycyrrhetinic acid were quantified by a sensitive liquid chromatography-tandem mass spectrometric (LC-MS) method.
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