SOD3 overexpression alleviates cerebral ischemia-reperfusion injury in rats.

Background: Ischemic stroke is a deadly disease that poses a serious threat to human life. Superoxide dismutase 3 (SOD3, ECSOD) is the main antioxidant enzyme that removes superoxide anions from cells. This study aimed to investigate the effect of SOD3 overexpression on cerebral ischemia-reperfusion injury in rats.

Genetic polymorphisms in the gene and the risk of ischemic stroke in a Chinese han population.

Background: Previous studies have shown that aldehyde dehydrogenase 2 () plays a role in ischemic stroke progression. In recent years, the activation of the pathway have been reported serving as a useful index in the identification of stroke-prone participants, and the pathway may be a potential target for the therapeutic intervention in ischemic stroke.

Materials And Methods: We evaluated six tagging single-nucleotide polymorphisms (SNPs) of the gene in a case-control study from Hainan of China (488 cases, 503 controls).

Association analysis of gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population.

This study aimed to assess the association of gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we genotyped 14 single nucleotide polymorphisms (SNPs) in 3 genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the χ2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a value of 0.

Hyperthermia influences fate determination of neural stem cells with lncRNAs alterations in the early differentiation.

Background: Temperature is an important parameter in the microenvironment of neural stem cells (NSCs); however, little is known about the precise effects of hyperthermia on fate determination in NSCs or the role of long non-coding (lnc)RNAs in this process. This was addressed in the present study using NSCs cultured at two different temperatures.

Methods: NSCs were divided into 37NSC and 40NSC groups that were cultured at 37°C or 40°C, respectively, for 72 h.