Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity.

Hyperoside is an active ingredient in plants, such as in Hypericaceae, in Rosaceae and in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver, among others. Pharmacokinetic analysis of hyperoside has revealed that it mainly accumulates in the kidney.

Continuous tuning the wetting growth of Au on Se nanoparticles.

We show that the wetting growth of Au on Se seed nanoparticles can be continuously tuned through manipulating the growth kinetics - the reduction rate of HAuCl and the inhibiting effect of DPI-SH ligand. As a result, a series of Se-Au hybrids and anisotropic Au semi-shell structures with different sizes were successfully obtained. With the structural variations, the absorptions of Se-Au hybrids and LSPRs of the Au semi-shells can be continuously tuned within the Visible-NIR spectral range.

A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway.

Ethnopharmacological Relevance: Bupleurum chinense DC has a history of using herb in China for more than 2000 years, which can be traced back to the Classic of Shennong Materia Medica in the Han Dynasty. Although Saikosaponin, the main active ingredient of Bupleurum, has the effects of anti-tumor, yet we still do not know the mechanism by total Bupleurum saponin extracts (TBSE) produces this effect on colon cancer.

Aim Of The Study: It is predicted by network pharmacology that TBSE may play an anti-colon cancer role by regulating the PI3K-Akt-mTOR pathway.