Opal-Inspired SiO-Mediated Carbon Dot Doping Enables the Synthesis of Monodisperse Multifunctional Afterglow Nanocomposites for Advanced Information Encryption.

Despite recent advancements in inorganic and organic phosphors, creating monodisperse afterglow nanocomposites (NCs) remains challenging due to the complexities of wet chemistry synthesis. Inspired by nanoinclusions in opal, we introduce a novel SiO-mediated carbon dot (CD) doping method for fabricating monodisperse, multifunctional afterglow NCs. This method involves growing a SiO shell matrix on monodisperse nanoparticles (NPs) and doping CDs into the SiO shell under hydrothermal conditions.

Injectable gelatin/oxidized dextran hydrogel loaded with apocynin for skin tissue regeneration.

Acute skin injury should be treated in time, due to many factors will affect the normal healing process of wounds, hinder tissue regeneration, and eventually form chronic wounds. Herein, an injectable, in-situ gel-forming hydrogel has been fabricated. The hydrogel is stabilized by dynamic Schiff base and composed of gelatin (Gel), oxidized dextran (Odex) and apocynin (Apo).

Injectable multifunctional CMC/HA-DA hydrogel for repairing skin injury.

Injectable Hydrogels with adhesive, antioxidant and hemostatic properties are highly desired for promoting skin injury repair. In this study, we prepared a multi-functional carboxymethyl chitosan/hyaluronic acid-dopamine (CMC/HA-DA) hydrogel, which can be crosslinked by horseradish peroxidase and hydrogen peroxide. The antioxidation, gelation time, degradability, rheology and antihemorrhagic properties of hydrogels can be finely tuned by varying composition ratio.

The Development of Hyaluronic Acids Used for Skin Tissue Regeneration.

Burns, mechanical injuries, skin defects, poor wound healing and scars caused by chronic diseases are serious clinical issues that affect millions of people around the world. Hyaluronic acid (HA) is one of the main components of extracellular matrix, which is widely distributed in human body. Because of its unique physical and chemical properties and diversity of physiological functions, hyaluronic acid is widely used in tissue engineering and regenerative medicine.

: A Medicinal Plant Used in Skin Wound Healing.

Skin injury is a major problem threatening human physical and mental health, and how to promote wound healing has been the focus. Developing new wound dressings is an important strategy in skin regeneration. is a medicinal plant with a long history, complex constituents, and various pharmacological activities.

Benlysta-Loaded Sodium Alginate Hydrogel and Its Selective Functions in Promoting Skin Cell Growth and Inhibiting Inflammation.

Benlysta is a new drug approved by the US Food and Drug Administration (US FDA) in 2019 for the treatment of systemic lupus erythematosus. In this study, we loaded the benlysta in the traditional sodium alginate (SA) hydrogel to investigate the potential application of the drug-loaded hydrogel for skin dressing or hypodermic drug. Live/dead staining images and the CCK-8 results showed that the benlysta-loaded hydrogel could promote the growth of human epidermal cells (HaCat), fibroblasts (L929), and endothelial cells while inhibiting the aggregation of inflammatory cells (macrophages).

Environmentally responsive hydrogels for repair of cardiovascular tissue.

Cardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury are major obstacles to this therapy. Recently, the development of hydrogel scaffold materials provides a new way to solve this problem, which have shown the potential to treat CVD.

Recent Advances in Extracellular Matrix for Engineering Stem Cell Responses.

Stem cell transplantation is an advanced medical technology, which brings hope for the treatment of some difficult diseases in the clinic. Attributed to its self-renewal and differential ability, stem cell research has been pushed to the forefront of regenerative medicine and has become a hot topic in tissue engineering. The surrounding extracellular matrix has physical functions and important biological significance in regulating the life activities of cells, which may play crucial roles for in situ inducing specific differentiation of stem cells.