Benzotrithiophene-based covalent organic frameworks for sensitive fluorescence detection and efficient removal of Ag from drinking water.

The simultaneous detection and removal of Ag from drinking water was crucial for preventing human health, while it was also extremely challenging due to bifunctional materials that combine both Ag adsorption and detection functions rarely being explored. In this study, a benzotrithiophene-based covalent organic framework (TAPA-BTT) was synthesized and applied to detect and remove Ag. TAPA-BTT exhibited high crystallinity, a large specific surface area, and good thermal stability.

Bile acids alleviate intestinal inflammation by modulating gut microbiota composition in LPS-challenged broilers.

Previous research has identified bile acids (BAs) as a valuable supplement for animal feed, especially in the poultry industry. However, there is limited research on the use of bile acids as a preventative measure against intestinal inflammation in broilers. This study aims to investigate the impact of dietary BAs on LPS-triggered intestinal inflammation in broilers.

Lower limb joint reaction forces during sit-to-stand and stand-to-sit movements in stroke patients with spastic hemiplegia.

Objective: We investigated the characteristics of hip, knee, and ankle joint reaction forces (JRFs) in stroke patients with spastic hemiplegia during sit-to-stand (Si-St) and stand-to-sit (St-Si) movements and explored the relationship between JRFs and joint moments.

Methods: Thirteen stroke patients with spastic hemiplegia and thirteen age-matched healthy subjects were recruited in this study. Three-dimensional motion capture system and force plates were employed to collect kinematic data and ground reaction forces during Si-St and St-Si tasks.

One-step biomineralization to synthesize reusable CRL@ZnCo-MOF for boosting lipase stability and sustainable dibutyl phthalate removal.

Adsorption and biodegradation are two important means to remove the pollutants from the environment, but how to combine them and improve the catalytic performance and stability of free enzyme are facing great challenges. Herein, lipase from Candida rugosa (CRL) was immobilized into bimetallic ZnCo-MOF by biomineralization, which not only significantly improved the catalytic activity and stability of CRL but also endowed it with excellent reusability. Furthermore, CRL@ZnCo-MOF established a synergetic system of combined adsorption and enzymatic degradation for the sustainable removal of dibutyl phthalate (DBP) in actual water environment.

Dual-template epitope imprinted nanoparticles for anti-glycolytic tumor-targeted treatment.

Glycolysis provides tumors with abundant nutrients through glucose (Glu) metabolism. As a therapeutic target, precise targeting and effective inhibition of the glycolysis process remains a major challenge in anti-metabolic therapy. In this study, a novel dual-template molecularly imprinted polymer (D-MIP), capable of specifically recognizing glucose transporter member 1 (GLUT1) and hexokinase-2 (HK2) was prepared for anti-glycolytic tumor therapy.

The impact of maternal mindful parenting on preschoolers' emotional regulation abilities: The mediating role of depression and the moderating role of the parent-child relationship.

Purpose: An examination into the effects of maternal variables on children's emotional regulation abilities, as well as the processes that underlie these effects, may improve our ability to effectively promote the development of children's emotional regulation ability. This study looks at how maternal depression influences the relationship between mindful parenting and children's emotional regulation ability. It also investigates the potential moderating effects of the parent-child relationship.

Immunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders.

To investigate the regulatory mechanism mediated by hypothalamic OPN5 on seasonal changes in the reproductive activities of domestic geese, 60 Magang ganders in their breeding period were selected for the experiment and evenly divided into an immunization group(OPN5-IM) and a control group. On days 0, 15 and 30, ganders in the immunized group were immunized with OPN5-KLH protein vaccine, and ganders in the control were immunized with the same amount of blank emulsified vaccine. Additionally, 120 female geese were provided to stimulate the reproductive activities of male geese.

Diamide insecticides in PM: The unreported rural and urban air pollutants.

The broad application of various pesticides guarantees the development of agriculture all over the word but has ultimately led to their ubiquitous release into the environment as hazardous chemical residues. Diamide insecticides (DAIs) are regarded as new choice for prevention and protection of agricultural crops and city landscaping plants from the pests in more and more countries. However, their presence in fine particulate matter (PM) and associated health risks have not been studied.

Toxic effects and mechanistic insights of cadmium telluride quantum dots on the homeostasis and regeneration in planarians.

The widespread application of quantum dots (QDs) in recent years has raised concerns about potential environmental and human health risks. Although the toxicity of cadmium telluride quantum dots (CdTe QDs) has been partially studied, their effects on stem cells, tissue regeneration, neurodevelopment, and neurobehavioral toxicity remain unclear. This study aimed to investigate the combined toxic effects and mechanisms of CdTe QDs on planarians at the individual, tissue, cellular, and molecular levels.

Quantitative source apportionment and health risk assessment for polycyclic aromatic hydrocarbon and their derivatives in indoor dust from housing and public buildings of a mega-city in China.

Indoor dust can adsorb various pollutants and long-term deposition can significantly impact air quality and human health. This study investigated the occurrence, source apportionment, and health risks associated with polycyclic aromatic hydrocarbons (PAHs) and their derivatives (d-PAHs) in indoor dust, by focusing on residential and public buildings in Nanjing, China. The concentration of 16 PAHs and 27 d-PAHs ranged from 511 to 5472 ng/g and from 422 to 2904 ng/g, with the most abundant compounds being fluoranthene and 1,2-benz[a]anthraquinone, respectively.

Ultrathin zwitterionic COF membranes from colloidal 2D-COF towards precise molecular sieving.

Membrane technology is an important component of resource recovery. Covalent organic frameworks (COFs) with inherent long-range ordered structure and permanent porosity are ideal materials for fabricating advanced membrane. Zwitterionic COFs have unique features beyond single ionic COFs containing anions or cations.

Interaction of inflammatory factors related to pulmonary infection and TLR4/NF-κB signaling pathway in patients with spontaneous intracerebral hemorrhage.

Objective: To investigate the interaction of inflammatory factors related to pulmonary infection and the TLR4/NF-κB signaling pathway in patients with spontaneous intracerebral hemorrhage (ICH).

Methods: A total of 325 critically ill ICH patients treated in our hospital from May 2021 to February 2024 were selected for this study. Based on whether the patient developed a pulmonary infection during treatment, they were divided into the infection group (n = 86) and the non-infection group (n = 239).

Low-Intensity Pulsed Ultrasound Delays the Onset of Osteoporosis and Dyslipidemia in Mice With Premature Ovarian Insufficiency.

Objectives: The pathogenesis of premature ovarian insufficiency (POI) not only affects the ovarian structure and function but also gives rise to complications such as osteoporosis and dyslipidemia. Although low-intensity pulsed ultrasound (LIPUS) has been proven effective in treating POI, its impact on the associated complications remains unexplored. Therefore, this study aims to investigate the effects of LIPUS irradiation on osteoporosis and dyslipidemia in a mouse model of POI.

Diagnostic accuracy of Xpert MTB/RIF Ultra for detecting pulmonary tuberculosis and rifampicin resistance: a systematic review and meta-analysis.

Background: Public health issues related to tuberculosis still exist. Because Xpert MTB/RIF Ultra is more effective than conventional TB diagnostic techniques are, it is now regarded as an emerging technology. The diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculosis was assessed in this systematic study.

Anisotropic Plasmon Resonance in TiCT MXene Enables Site-Selective Plasmonic Catalysis.

The ever-growing interest in MXenes has been driven by their distinct electrical, thermal, mechanical, and optical properties. In this context, further revealing their physicochemical attributes remains the key frontier of MXene materials. Herein, we report the anisotropic localized surface plasmon resonance (LSPR) features in TiCT MXene as well as site-selective photocatalysis enabled by the photophysical anisotropy.

Cysteine-Specific F and NIR Dual Labeling of Peptides via Vinyltetrazine Bioorthogonal Conjugation for Molecular Imaging.

Radiolabeled peptides are vital for positron emission tomography (PET) imaging, yet the F-labeling peptides remain challenging due to harsh conditions and time-consuming premodification requirements. Herein, we developed a novel vinyltetrazine-mediated bioorthogonal approach for highly efficient F-radiolabeling of a native peptide under mild conditions. This approach enabled radiosynthesis of various tumor-targeting PET tracers, including targeting the neurofibromin receptor (), the integrin αβ (), and the platelet-derived growth factor receptor β (), with a radiochemical yield exceeding 90%.

Elucidating Binding Selectivity in Cyclin-Dependent Kinases 4, 6, and 9: Development of Highly Potent and Selective CDK4/9 Inhibitors.

CDK4/6 inhibitors are effective in treating HR/HER2 breast cancer but face limitations due to therapeutic resistance and hematological toxicity, particularly from strong CDK6 inhibition. To address these challenges, designing selective inhibitors targeting specific cyclin-dependent kinases (CDK) members could offer clinical advantages and broaden CDK inhibitor indications. However, the highly conserved binding pockets of CDKs complicate selective targeting.

Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC.

The tedious synthesis and limited throughput biological evaluation remain a great challenge for discovering new proteolysis targeting chimera (PROTAC). To rapidly identify potential PROTAC lead compounds, we report a platform named Auto-RapTAC. Based on the modular characteristic of the PROTAC molecule, a streamlined workflow that integrates lab automation with "click chemistry" joint building-block libraries was constructed.

Clinical Value of Abnormal Prothrombin and Carbohydrate Antigen 125 in the Diagnosis of Patients With Gallbladder Cancer.

Objective: This study was aimed at ascertaining the application value of abnormal prothrombin (PIVKA-II) and carbohydrate antigen 125 (CA125) in gallbladder cancer (GBC) diagnosis.

Methods: A total of 70 GBC patients, 70 patients with benign gallbladder diseases (gallbladder stones and gallbladder polyps), and 70 normal health examination people were selected as the malignant, benign, and normal groups, respectively. The differences in serum levels and positive rates of PIVKA-II and CA125 were compared.

Spatial frequency of environments and myopia: A systematic review on associated evidence and underlying mechanisms.

Purpose: Previous animal studies have found a relationship between spatial frequency and myopia. New research in humans suggest that reduced high spatial content of the visual environment may be a contributing factor for myopia development. This study aims to review the literature and elucidate the potential biological mechanisms linking spatial frequency and myopia.

Effects of Light and Laser Therapies on the Microecosystem of Sebaceous Glands in Acne Treatment.

Background: Acne vulgaris (acne) is one of the most common skin diseases with complex pathogenesis. Numerous studies have shown that the microecosystem of sebaceous glands and Cutibacterium acnes play key roles in its pathogenesis. Antibiotics targeting C.

Estrogen, estrogen receptor and the tumor microenvironment of NSCLC.

Lung cancer remains the foremost cause of cancer-related mortality worldwide. Clinical observations reveal a notable increase in both the proportion and mortality rate among female non-small cell lung cancer (NSCLC) patients compared to males, a trend that continues to escalate. Extensive preclinical research underscores the pivotal role of estrogen in the initiation, progression, prognosis, and treatment response of NSCLC.

Development of a robust and efficient virus-induced gene silencing system for reverse genetics in recalcitrant Camellia drupifera capsules.

Background: Virus-induced gene silencing (VIGS) is a rapid and powerful method for gene functional analysis in plants that pose challenges in stable transformation. Numerous VIGS systems based on Agrobacterium infiltration has been widely developed for tender tissues of various plant species, yet none is available for recalcitrant perennial woody plants with firmly lignified capsules, such as tea oil camellia. Therefore, there is an urgent need for an efficient, robust, and cost-effective VIGS system for recalcitrant tissues.

The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study.

Objective: This study aims to elucidate the therapeutic efficacy and safety of a taxane-based chemotherapy in combination with immune checkpoint inhibitors regimen in patients diagnosed with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).

Methods: We retrospectively collected clinical data from 154 patients who received at least two cycles of PD-1 inhibitors in combination with a taxane-based chemotherapy as first-line treatment in seven hospitals in Hunan Province, between December 2018 and December 2023. These patients were subjected to long-term follow-up.

A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma.

Background: Disease progression within 24 months (POD24) significantly impacts overall survival (OS) in patients with follicular lymphoma (FL). This study aimed to develop a robust predictive model, FLIPI-C, using a machine learning approach to identify FL patients at high risk of POD24.

Methods: A cohort of 1,938 FL patients (FL1-3a) from seventeen centers nationwide in China was randomly divided into training and internal validation sets (2:1 ratio).