Sporisorium reilianum polysaccharides improve DSS-induced ulcerative colitis by regulating intestinal barrier function and metabolites.

This study investigated the regulatory effects of Sporisorium reilianum polysaccharides (SRPS) on metabolism and the intestinal barrier in mice with colitis induced by dextran sulfate sodium (DSS). SRPS were resistant to the digestion of saliva, gastric juices, and intestinal fluid. SRPS significantly reduced the disease activity index and inhibited DSS-induced colon shortening.

A novel disulfidptosis-related lncRNAs signature for predicting survival and immune response in hepatocellular carcinoma.

The accumulation of intracellular disulfides induces a novel and unique form of metabolic-related cell death known as disulfidptosis. A previous study revealed the prognostic value of a risk model of disulfidptosis-related genes in hepatocellular carcinoma (HCC). However, to date, no studies have investigated the relationship between disulfidptosis-related long non-coding RNAs (DRLs) and HCC.

A Contribution to Improve Barrier Properties and Reduce Swelling Ratio of κ-Carrageenan Film from the Incorporation of Guar Gum or Locust Bean Gum.

In this study, galactomannan (GM), including guar gum (GG) or locust bean gum (LG), was incorporated into a κ-carrageenan film to improve barrier properties and reduce the swelling ratio (SR). The effects of that with different concentrations on optical, mechanical, barrier, swelling and thermal properties of the κ-carrageenan-based film were researched. SEM and rheological results showed that both κ-carrageenan/GG and κ-carrageenan/LG had good compatibility and stability.

Poly(ADP-ribose) promotes toxicity of arginine-rich dipeptide repeat proteins.

Arginine-rich dipeptide repeat proteins (R-DPRs), abnormal translational products of a GGGGCC hexanucleotide repeat expansion in , play a critical role in -related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the most common genetic form of the disorders (c9ALS/FTD). R-DPRs form liquid condensates in vitro, induce stress granule formation in cultured cells, aggregate, and sometimes coaggregate with TDP-43 in postmortem tissue from patients with c9ALS/FTD. However, how these processes are regulated is unclear.

Using expression quantitative trait loci data and graph-embedded neural networks to uncover genotype-phenotype interactions.

A central goal of current biology is to establish a complete functional link between the genotype and phenotype, known as the so-called genotypephenotype map. With the continuous development of high-throughput technology and the decline in sequencing costs, multi-omics analysis has become more widely employed. While this gives us new opportunities to uncover the correlation mechanisms between single-nucleotide polymorphism (SNP), genes, and phenotypes, multi-omics still faces certain challenges, specifically: 1) When the sample size is large enough, the number of omics types is often not large enough to meet the requirements of multi-omics analysis; 2) each omics' internal correlations are often unclear, such as the correlation between genes in genomics; 3) when analyzing a large number of traits (), the sample size () is often smaller than , hindering the application of machine learning methods in the classification of disease outcomes.

Microcystic urothelial carcinoma: a case report.

Microcystic urothelial carcinoma (MUC) is a rare variant of urothelial carcinoma that is highly aggressive with poor prognosis. Due to the scarcity of cases, its histologic morphology and immunohistochemical characteristics are still not clear. This paper reports a 71-year old female patient with gross hematuria and abdominal pain.

Mixed malignant peripheral nerve sheath tumor in the inguinal region: a case report.

Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant soft tissue tumor that accounts for approximately 5% of all soft tissue sarcomas. This tumor originates from the peripheral nerves and occurs mainly in the limbs, head and neck, and spine. As a more aggressive tumor, it has higher recurrence and metastasis rates, and patient prognosis is poor.

Bioinformatic analysis reveals CYP2C9 as a potential prognostic marker for HCC and liver cancer cell lines suitable for its mechanism study.

Hepatocellular carcinoma (HCC) is a common cancer and the sixth most lethal malignancy in the world. We chose gene expression profile of GSE14520 from GEO database aiming to find key genes that affect HCC progression. 22 paired tumor and non-tumor samples were included in this analysis.

Investigating the Promoter of FAT10 Gene in HCC Patients.

FAT10, which is also known as diubiquitin, has been implicated to play important roles in immune regulation and tumorigenesis. Its expression is up-regulated in the tumors of Hepatocellular Carcinoma (HCC) and other cancer patients. High levels of FAT10 in cells have been shown to result in increased mitotic non-disjunction and chromosome instability, leading to tumorigenesis.

Relating pancreatic ductal adenocarcinoma tumor samples and cell lines using gene expression data in translational research.

Cancer cell lines are useful tools to study cancer biology. Choosing proper cell lines based on experimental design for different experiments is vital. Relating tumors and cell lines, and recognizing their similarities and differences are thus very important for translational research.

TRPC1/3/6 inhibition attenuates the TGF-β1-induced epithelial-mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway.

Gastric cancer (GC) is one of the most common malignancies worldwide. TGF-β1 induces the epithelial-mesenchymal transition (EMT) in GC, mainly through Smad-dependent pathways. Nevertheless, few studies have focused on the activation of non-canonical transduction pathways.

Hepatitis B Virus X Protein and Hepatocarcinogenesis.

Chronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic and genetic processes.

Computed Tomography Imaging Measurement for Safer Cavernous Sinus Biopsy.

The aim of this study was to measure the relative location between foramen ovale and internal carotid artery. The results can guide surgeons to avoid damaging internal carotid artery in cavernous sinus biopsy. One hundred twenty people (73 men and 47 women) were involved in this study anonymously.

Locating of the pituitary stalk for craniopharyngioma surgery of transfrontobasal interhemispheric approach.

The aim of this study was to provide a relatively safe operation range for the protection of the pituitary stalk in transfrontobasal interhemispheric approach for craniopharyngioma surgery by measuring the related parameters of the pituitary stalk. Based on the whole-head magnetic resonance imaging scans of 119 healthy subjects (57 men and 62 women) anonymously, three-dimensional reconstructions were rebuilt. The results of the study are as follows: M is the common midpoint of anterior and inferior border of anterior commissure.

The safe zone of posterior semicircular canal resection in suboccipital retrosigmoid sinus approach for acoustic neuroma surgery.

The aim of the study was to find the safe zone of posterior semicircular canal resection that can avoid structure damage in suboccipital retrosigmoid sinus approach for acoustic neuroma. One hundred twenty subjects (72 male and 48 female subjects) were involved in this study anonymously. Five parameters are measured in computed tomography: L1 is the line that goes through the common bony crus and parallel to the plane that contains posterior semicircular canal at axial plane.

Optic canal location by computed tomography.

The aim of this study was to provide anatomic data for optic canal decompression. One hundred twenty people (55 males and 65 females) were involved in this study anonymously. Twelve parameters are measured in computed tomography: P1 is the nasal bone tip; P2 is the middle point of tuberculum sellae; P3 is the root of columella nasi; P4 is the cranium end of the optic canal; P5 is the orbit end of the optic canal; P1' is P1's projection on L2; L1 is the line that links P1 and P2; L2 goes through P3 and parallel to L1; L3 is the bisector of right and left and goes through P1.