Discovery of novel NSAID hybrids as cPLA/COX-2 dual inhibitors alleviating rheumatoid arthritis via inhibiting p38 MAPK pathway.

A series of NSAIDs hybrid molecules were synthesized and characterized, and their ability to inhibit NO release in LPS-induced RAW264.7 macrophages was evaluated. Most of the compounds showed significant anti-inflammatory activity in vitro, of which (2E,6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-2,6,9,12,15-pentaen-2-yl 2-(4-benzoylphenyl) propanoate (VI-60) was the most optimal (IC = 3.

Effect of Bimetal Element Doping on the Low-Temperature Activity of Manganese-Based Catalysts for NH-SCR.

A series of novel MnZrCo denitrification catalysts were prepared by the co-precipitation method. The effect of co-modification of MnO catalyst by zirconium and cobalt on the performance of NH-SCR was studied by doping transition metal cobalt into the MnZr catalyst. The ternary oxide catalyst MnZrCo can reach about 90% of NO conversion in a reaction temperature range of 100-275°C, and the best NO conversion can reach up to 99%.

Selective catalytic reduction of NO by low-temperature NH over Mn Zr mixed-oxide catalysts.

Mn Zr series catalysts were prepared by a coprecipitation method. The effect of zirconium doping on the NH-SCR performance of the MnO catalyst was studied, and the influence of the calcination temperature on the catalyst activity was explored. The results showed that the MnZr catalyst exhibited good NH-SCR activity when calcined at 400 °C.

Effect of Indium Addition on the Low-Temperature Selective Catalytic Reduction of NO by NH over MnCeO Catalysts: The Promotion Effect and Mechanism.

A MnCeInO catalyst was prepared by a coprecipitation method for denitrification of NH-SCR (selective catalytic reduction). The catalysts were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry, scanning electron microscopy, X-ray photoelectron spectroscopy, Brunauer-Emmett-Teller analysis, H temperature-programmed reduction, and NH temperature-programmed desorption. The NH-SCR activity and HO and SO resistance of the catalysts were evaluated.

Palladium-Catalyzed Asymmetric Trifluoromethylated Allylic Alkylation of Pyrazolones Enabled by α-(Trifluoromethyl)alkenyl Acetates.

The first asymmetric trifluoromethylated allylic alkylation of pyrazolones using α-(trifluoromethyl)alkenyl acetates as a novel trifluoromethylated allylation reagent is described, affording various functionalized chiral pyrazolones containing a trifluoromethylated allyl substituent in high yields with excellent regio-/enantio-/diastereoselectivities. Mechanistically, the double-bond migration of α-(trifluoromethyl)alkenyl acetates in the presence of 1,8-diazabicyclo[5.4.