Pharmacokinetics study of atracurium, dexmedetomidine, midazolam and 1-hydroxymidazolam in patients undergoing acute aortic dissection surgery.

Objective: An UPLC-MS/MS method was developed and validated for simultaneous determination of atracurium (ATC), dexmedetomidine (DEX), midazolam (MDZ) and 1-hydroxymidazolam (1-OH-MDZ) and the pharmacokinetics of ATC, DEX, MDZ and 1-OH-MDZ in patients undergoing aortic dissection surgery were investigated.

Methods: The analytes were extracted by acetonitrile precipitation and separated on an Acquity UPLC BEH C18 column (2.1 mm × 50 mm, 1.

Excitation wavelength-dependent lanthanide-disalicylaldehyde coordination hybrid capable of distinguishing DO from HO.

The increasing demands in fields of anti-counterfeiting, fluorescence analysis, clinical therapy and LED illumination are urgently eager for more excellent optically switchable luminescent materials with the stable and multimodal fluorescence in single-component matrix. Herein, the lanthanide-disalicylaldehyde coordination hybrid HQ/TbEu is proposed as an efficient luminescent matrix to connect terbium sensibilization with ESIPT (excited-state intramolecular proton transfer) effects, and three multi-emission hybrids are finally designed and synthesized by regulating Tb and Eu ratios. Surprisingly, the HQ/TbEu shows the excitation wavelength-dependent luminescence in solution which originates from two energy transfer ways of terbium sensibilization effect.

A dynamic Eu(III)-macrocycle served as the turn-on fluorescent probe for distinguishing HO from DO.

HO and DO are an important pair of analogues, and their high-efficient detections are closely related to fields of chemical industry, food processing, semiconductor, environmental monitoring, etc. Because of their extremely similar physical and chemical properties, HO and DO can be mutually soluble in any ratios, and it is generally thought that the discrimination of HO and DO is an enormous challenge. Herein, upon the fact that vibrational frequency of O-H is greater than O-D, we design a dynamic Eu(III)-macrocycle Eu-2 with two emitters which exhibits the imine bond breakage of macrocycle emitter HL2 in HO or DO, resulting in the turn-on fluorescence of Eu(III) emitter.