Secondary metabolites and their bioactivities from YMF1.00003.

Four new polyketides (-) and seven known compounds (-) including three polyketides and four sterols were isolated from the fermented extracts of YMF1.00003. The new chemical structures were determined through the analysis of the nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry, and their configurations were subsequently confirmed by nuclear overhauser effect spectroscopy, the calculated electronic circular dichroism (ECD) spectra, and quantum chemical calculations of the NMR data (qcc NMR).

Activities and metabolomics of under different culture conditions.

Many active metabolites have been identified from various species of the fungal genus . A predominant species of this genus is , but there are limited reports on the active ingredients from this species. This study aimed to conduct activity assays and metabolome analysis on extracts of obtained under different culture conditions.

Metabolites and Their Bioactivities from the Genus .

The genus is a group of ascomycete parasitic fungi, and all known species of this genus are endoparasites; they mainly feed on insects or arthropods and a few feed on other fungi. Fungi of this genus have evolved highly specific and complex mechanisms to escape their host's immune system and coordinate their life cycle coefficients with those of their hosts for survival and reproduction; this mechanism has led to the production of distinctive metabolites in response to the host's defenses. Herein, we review approximately 131 metabolites discovered in the genus (including mycelium, fruiting bodies and fungal complexes) in the past 15 years, which can be used as an important source for new drug research and development.