Palladium-catalyzed carboxylative cyclization of propargylic amines with aryl iodides, CO and CO under ambient pressure.

A palladium-catalyzed four-component carboxylative cyclization comprising propargylic amines, aryl iodides, CO and CO was developed. By selecting EtN and 1,5,7-triazabicyclo[4.4.

Visible light-driven carbamoyloxylation of the α-C(sp)-H bond of arylacetones radical-initiated hydrogen atom transfer.

Photocatalytic synthesis has emerged as an efficient route to transform CO into functionalized organic carbamates by photocatalysis. Herein, a catalyst-free carbamoyloxylation of arylacetones with CO and amines under visible light was developed for the synthesis of -β-oxoalkyl carbamates in yields up to 93%. This protocol proceeded smoothly with the assistance of inexpensive carbon tetrabromide at room temperature under atmospheric CO pressure, leading to simultaneous construction of C-O and C-N bonds.