Coordination-Induced Multivalent Self-Assembling Catalysts for Spectral Sensing Zn with High Selectivity and Sensitivity.

The introduction of signal amplification to molecular spectral sensing systems is an intriguing topic in supramolecular analytical chemistry. In this study, click chemistry was used to generate a triazole moiety to bridge with a long hydrophobic alkyl chain (C) and another short alkyl chain (C) bearing a 1,4,7-triazacyclonane (TACN) group for efficiently generating a self-assembling multivalent catalyst, C-triazole-C-TACN·Zn ( and represent the carbon numbers of both alkyl chains, respectively; = 16, 18, and 20; = 2 and 6), to catalyze the hydrolysis of 2-hydroxypropyl-4-nitrophenyl phosphate (HPNPP) when Zn was added. The triazole moiety introduced adjacent to the TACN group plays an important role in improving the selectivity of Zn because the triazole moiety can participate in the coordination interaction between the Zn and neighboring TACN group.

Minimalistic Artificial Catalysts with Esterase-Like Activity from Multivalent Nanofibers Formed by the Self-Assembly of Dipeptides.

Imitating and incorporating the multiple key structural features observed in natural enzymes into a minimalistic molecule to develop an artificial catalyst with outstanding catalytic efficiency is an attractive topic for chemists. Herein, we designed and synthesized one class of minimalistic dipeptide molecules containing a terminal -SH group and a terminal His-Phe dipeptide head linked by a hydrophobic alkyl chain with different lengths, marked as HS-C -His-Phe ( = 4, 7, 11, 15, and 17; + 1 represents the carbon atom number of the alkyl chain). The His (-imidazole), Phe (-CO ) moieties, the terminal -SH group, and a long hydrophobic alkyl chain were found to have important contributions to achieve high binding ability leading to outstanding absolute catalytic efficiency ( / ) toward the hydrolysis reactions of carboxylic ester substrates.

Relationship between obstructive sleep apnea and coronary microcirculatory function among patients with cardiac syndrome X.

Objectives: Obstructive sleep apnea (OSA) is an emerging risk factor for cardiovascular disease. Microcirculatory dysfunction has been proposed as a potential mechanism in the pathogenesis of cardiovascular disease in OSA. This study aims to investigate the relationship between OSA and coronary microcirculatory function.

Correlation between plasma lipoprotein-associated phospholipase A and peripheral arterial disease.

Lipoprotein-associated phospholipase A (Lp-PLA) is a recently identified and potentially useful plasma biomarker for cardiovascular diseases. However, its role in peripheral arterial disease (PAD) remains unclear. The objective of this study was to assess the independent association of Lp-PLA and other inflammatory markers with the reduced ankle-brachial blood pressure index (ABI), a marker of PAD.

Myeloperoxidase and risk of recurrence of atrial fibrillation after catheter ablation.

Background: Myeloperoxidase (MPO) has been associated with the development of atrial fibrillation (AF), but its impact on the recurrence of AF after catheter ablation has not been explored. This study investigated the effect of plasma MPO on recurrence after catheter ablation of paroxysmal AF.

Methods And Results: Two hundred eighty-eight consecutive patients with paroxysmal AF and who underwent circumferential pulmonary vein isolation were prospectively enrolled.