RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway.

As cervical cancer (CC) caused more than 300,000 deaths in the world, it is urgent to identify therapeutic targets to improve survival. Though RUNX1 is overexpressed in CC, its specific role and underlying molecular mechanisms remain incompletely understood. Here we presented that RUNX1 was upregulated in CC and associated with poor prognosis.

Large Manipulation of Ferrimagnetic Curie Temperature by A-Site Chemical Substitution in ACuFeReO (A = Na, Ca, and La) Half Metals.

CaCuFeReO and LaCuFeReO quadruple perovskite oxides are well known for their high ferrimagnetic Curie temperatures and half-metallic electronic structures. By A-site chemical substitution with lower valence state Na, an isostructural compound NaCuFeReO with both A- and B-site ordered quadruple perovskite structures in -3 symmetry was prepared using high-pressure and high-temperature techniques. The X-ray absorption study demonstrates the valence states to be Cu, Fe, and Re.

Extracellular Vesicles Derived from Lipopolysaccharide-Pretreated Periodontal Ligament Stem Cells Ameliorate Inflammatory Responses in Experimental Colitis via the PI3K/AKT Signaling Pathway.

Introduction: Inflammatory bowel disease is a complex chronic inflammatory condition characterized by dysbiosis of the gut microbiota and dysregulation of immune system. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells have garnered significant attention for their beneficial potentials in immune modulation and tissue repair. This study aims to evaluate the therapeutic effects and underlying mechanisms of EVs derived from lipopolysaccharide (LPS)-pretreated periodontal ligament stem cells (PDLSCs) in mice with colitis.

Effects of Saccharomyces boulardii on microbiota composition and metabolite levels in the small intestine of constipated mice.

Saccharomyces boulardii (S. boulardii) is a fungal probiotic used to treat digestive disorders. However, the mechanism(s) by which S.

Transition-metal-free photochemical reductive denitration of nitroarenes.

We have developed a simple and mild photochemical process for the reductive denitration of nitroarenes under transition-metal-free conditions. This method is compatible with a broad range of functional groups, providing a practical and efficient approach for converting nitroarenes into denitrated arenes. The utility of this protocol is demonstrated through the prompt synthesis of dibenzoxepane.

Stable Field Emission from Single-Crystalline Zirconium Carbide Nanowires.

The <100> oriented single-crystalline Zirconium Carbide (ZrC) nanowires were controllably synthesized on a graphite substrate by chemical vapor deposition (CVD) with optimized growth parameters involving Zirconium tetrachloride (ZrCl), flow of methane (CH), and growth temperature. The length of nanowires is above 10 µm while the diameter is smaller than 100 nm. A single ZrC nanowire was picked up and fixed on a tungsten tip for field emission measurement.

Simultaneous removal of nutrients and pharmaceuticals and personal care products using two-stage woodchip bioreactor-biochar treatment systems.

The co-occurrence of nutrients and pharmaceuticals and personal care products (PPCPs) in sewage effluent can degrade water quality of the receiving watersheds. This study investigated the simultaneous removal of excess nutrients and PPCP contaminants by developing a novel woodchip bioreactor and biochar (B) treatment system. The result revealed that woodchip bioreactors could effectively remove nitrate via a denitrification process and adsorb some PPCPs.

One-Step Synthesis of Heterostructured Mo@MoO Nanosheets for High-Performance Supercapacitors with Long Cycling Life and High Rate Capability.

Supercapacitors have gained increased attention in recent years due to their significant role in energy storage devices; their impact largely depends on the electrode material. The diversity of energy storage mechanisms means that various electrode materials can provide unique benefits for specific applications, highlighting the growing trend towards nanocomposite electrodes. Typically, these nanocomposite electrodes combine pseudocapacitive materials with carbon-based materials to form heterogeneous structural composites, often requiring complex multi-step preparation processes.

Protective role of TRPM7 knockdown in ulcerative colitis via blocking NLRP3 inflammasome-mediated pyroptosis.

Transient receptor potential melastatin 7 (TRPM7) has been emerged as a potent drug target for immunomodulation with ion conductance and kinase activities. The research is projected to characterize the influences of TRPM7 on the course of ulcerative colitis (UC) and dissect the latent response mechanisms. The in vivo murine model and in vitro cell model of UC were both stimulated by DSS.

The clinical value of carbon nanoparticles in sentinel lymph node biopsy for early vulvar cancer.

Objective: Carbon nanoparticle (CNP)-guided sentinel lymph node biopsy (SLNB) has been extensively adopted as a cost-effective and highly efficient method for tracing malignant tumors except for those associated with vulvar cancer. The current study aimed to validate the feasibility and efficacy of CNPs in tracking sentinel lymph nodes (SLNs) in patients with early vulvar cancer.

Methods: We retrospectively reviewed patients with vulvar cancer at our institution from January 2016 to April 2022 who were pathologically diagnosed and underwent SLNB or inguinofemoral lymphadenectomy (IFLND).

Organic Thiolate as Multifunctional Salt for Rechargeable Lithium-Sulfur Batteries.

The practical application of lithium-sulfur (Li-S) batteries is hindered by the severe shuttle effect of soluble polysulfide intermediates and the unstable lithium anode interface. Conventional lithium salts (e.g.

Cross-linked modification of tapioca starch by sodium Trimetaphosphate: An influence on its structure.

This study aimed to examine the changes in the structural characterization of cross-linked tapioca treated with sodium trimetaphosphate(STMP). The degree of substitution in the cross-linked starch was determined by the iodine absorption method. Scanning electron microscopy, particle size measurement, Fourier-transform infrared spectroscopy (FT-IR), and x-ray diffraction (XRD) were used to characterize the structure of modified tapioca starch at different substitution degrees.

Microglia Promote Lymphangiogenesis Around the Spinal Cord Through VEGF-C/VEGFR3-Dependent Autophagy and Polarization After Acute Spinal Cord Injury.

Reducing secondary injury is a key focus in the field of spinal cord injury (SCI). Recent studies have revealed the role of lymphangiogenesis in reducing secondary damage to central nerve. However, the mechanism of lymphangiogenesis is not yet clear.

Customizable beam splitting in planar adiabatic acoustic couplers composed of cylindrical scatterers.

In this work, five-waveguide (five-WG) acoustic couplers with planar configurations are designed based on quantumlike adiabatic transfer, through which the incident waves can efficiently transfer from the middle WG to the other two WGs with a customized intensity ratio. The five WGs are connected by space-varying cylindrical scatterers, and the coupling between two adjacent WGs is determined by two Gaussian pulses with a certain delay. Since the evolution process of acoustic waves can adiabatically follow the dark state, the coupler could have a broadband and stable performance.

Carrier effects of face mask-derived microplastics on metal ions: Enhanced adsorption by photoaging combined with biofilms, exemplified with Pb(Ⅱ).

Face masks have emerged as a significant source of microplastics (MPs) under the influence of biotic and abiotic interactions. However, the combined effects of abiotic photoaging and biofilm-loading on mask-derived MPs as carriers of metal ions are not clear. We investigated the Pb(Ⅱ) adsorption onto polypropylene (PP) and polyurethane (PU) mask-derived MPs treated by photoaging, biofilm-loading, and both combinations, evaluating the composite risks.

Effect of salt substitute and antihypertensive medications among high cardiovascular risk patients: A sub-study of Salt Substitute and Stroke Study (SSaSS).

The relationship between the differential protective effect of salt substitute between hypertensive and normotensive individuals and the use of cardiovascular medications remains unclear. This study involved 4211 individuals with a history of stroke or hypertension who participated in the Salt Substitute and Stroke Study (SSaSS) from 120 villages in Shanxi Province. The aim of this study was to investigate the differences in major adverse cardiovascular events and blood pressure changes between the salt substitute and the regular salt group in the subgroups of participants taking different antihypertensive medications.

Comparison of patient-controlled epidural analgesia and epidural morphine for post-cesarean section analgesia: experience from a tertiary center in China.

Purpose: To compare patient-controlled epidural analgesia (PCEA) and epidural morphine (EM) for post-cesarean section analgesia in real-world experience from China.

Methods: Parturients receiving one dose of EM (1-2 mg), PCEA, or both EM and PCEA from Peking Union Medical College Hospital were retrospectively recruited. Logistic models were used to identify risk factors.

Dependence of Ultrafast Electron Emission Characteristics of Graphene Cold Cathode on Femtosecond Photoexcitation Polarization Angle.

Ultrafast electron pulses, generated through femtosecond photoexcitation in nanocathode materials, introduce high-frequency characteristics and ultrahigh temporal-spatial resolution to vacuum micro-nano electronic devices. To advance the development of ultrafast electron sources sensitive to polarized light, we propose an ultrafast pulsed electron source based on a vertical few-layer graphene cold cathode. This source exhibits selective electron emission properties for varying polarization angles, with high switching ratios of 277 (at 0°) and 235 (at 90°).

Fabric structure and polymer composition as key contributors to micro(nano)plastic contamination in face masks.

The surge in face mask use due to COVID-19 has raised concerns about micro(nano)plastics (MNPs) from masks. Herein, focusing on fabric structure and polymer composition, we investigated MNP generation characteristics, mechanisms, and potential risks of surgical polypropylene (PP) and fashionable polyurethane (PU) masks during their wearing and photoaging based on stereomicroscope, μ-Fourier transform infrared spectroscopy (μ-FTIR), and scanning electron microscope (SEM) techniques. Compared with new PP and PU masks (66 ± 16 MPs/PP-mask, 163 ± 83 MPs/PU-mask), single- and multiple-used masks exhibited remarkably increased MP type and abundance (600-1867 MPs/PP-mask, 607-2167 MPs/PU-mask).

Optimization of an Ultrasound-Assisted Extraction Technique and the Effectiveness of the Sunscreen Components Isolated from .

is the dried tuber of (Thund.) Reichb.f.

PGC-1α/LDHA signaling facilitates glycolysis initiation to regulate mechanically induced bone remodeling under inflammatory microenvironment.

The mechanosensitivity of inflammation can alter cellular mechanotransduction. However, the underlying mechanism remains unclear. This study aims to investigate the metabolic mechanism of inflammation under mechanical force to guide tissue remodeling better.

Field-Emission Energy Distribution of Carbon Nanotube Film and Single Tube under High Current.

A narrow energy distribution is a prominent characteristic of field-emission cold cathodes. When applied in a vacuum electronic device, the cold cathode is fabricated over a large area and works under a high current and current density. It is interesting to see the energy distribution of the field emitter under such a working situation.

A Retrospective Cohort Study of vNOTES Extraperitoneal Versus Laparoscopic Sacral Hysteropexy With Uterine Preserving Regarding Surgical Outcomes and Two-Year Follow-Up Results.

Study Objective: To explore the effectiveness of transvaginal natural orifice transluminal endoscopic surgery extraperitoneal sacral hysteropexy (vNOTES-ESH) in women with symptomatic uterine prolapse over a 2 year follow-up.

Design: Retrospective cohort study.

Setting: Gynecological minimally invasive center.