Biosilicification-mimicking chiral nanostructures for targeted treatment of inflammatory bowel disease.

The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development of inflammatory bowel disease (IBD). Herein, we construct polyethylenimide (PEI)-L/D-tartaric acid (L/D-TA) complexes templated mesoporous organosilica nanoparticles (MON) (PEI-L/D-TA@MON) by mimicking biosilicification under ambient conditions within seconds. The chiral nanomedicines include four functional moieties, wherein PEI electrostatically attracts cfDNA, tetrathulfide bonds reductively react with ROS, silanol groups adsorb LPS, and L/D-TA enables chiral recognition and inflammatory localization.

SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1.

Ageing-induced skeletal muscle deterioration contributes to sarcopenia and frailty, adversely impacting the quality of life in the elderly. However, the molecular mechanisms behind primate skeletal muscle ageing remain largely unexplored. Here, we show that SIRT5 expression is reduced in aged primate skeletal muscles from both genders.

A survey of emergency medicine physicians' knowledge, attitude, and practice towards esophagogastric variceal bleeding.

Background: Esophageal-gastric variceal bleeding (EVB) is one of the leading causes of mortality in patients with cirrhotic portal hypertension. Rapid, accurate, and effective emergency care is crucial for successful patient outcomes.

Aims: This study aims to evaluate the knowledge, attitudes, and practices of Chinese emergency physicians regarding EVB, with the goal of improving the diagnosis and treatment of gastrointestinal bleeding in emergency settings.

Transfusion Thresholds and Risk Factors of Acute Kidney Injury in Gastrointestinal Oncology Surgery: Insights from a Retrospective Study.

: To identify transfusion thresholds and risk factors for acute kidney injury (AKI) in gastrointestinal oncology surgery, enhancing early intervention and improving postoperative outcomes. : From 2018 to 2022, 765 patients with gastric or colorectal cancer who underwent major gastrointestinal surgery were retrospectively enrolled. The primary outcome was AKI development within 7 days postoperatively.

Benchmarking copy number aberrations inference tools using single-cell multi-omics datasets.

Copy number alterations (CNAs) are an important type of genomic variation which play a crucial role in the initiation and progression of cancer. With the explosion of single-cell RNA sequencing (scRNA-seq), several computational methods have been developed to infer CNAs from scRNA-seq studies. However, to date, no independent studies have comprehensively benchmarked their performance.

Leveraging labelled data knowledge: A cooperative rectification learning network for semi-supervised 3D medical image segmentation.

Semi-supervised 3D medical image segmentation aims to achieve accurate segmentation using few labelled data and numerous unlabelled data. The main challenge in the design of semi-supervised learning methods consists in the effective use of the unlabelled data for training. A promising solution consists of ensuring consistent predictions across different views of the data, where the efficacy of this strategy depends on the accuracy of the pseudo-labels generated by the model for this consistency learning strategy.

LC-MS Guided Discovery and Biosynthetic Pathway of Coprisamides E-H, Cinnamic Acid-Containing Metabolites from the Marine Algae-Derived NAK03196.

Four cinnamoyl-containing nonribosomal peptides (CCNPs), coprisamides EH (-), were isolated from the marine algae-associated actinomycete strain NAK03196. Their structures were elucidated to be unreported coprisamides by comprehensive analyses of HRESIMS, 1D and 2D NMR spectroscopic data, Marfey's method, and MS/MS analysis. Coprisamides E () and F () bear a characteristic nonproteinogenic amino acid, 2,3-diaminopropanoic acid.

3D printing of microstructured polyacrylamide/sodium alginate/lithium chloride composite hydrogels for nanofriction generator and e-skin.

The development of wearable electronic devices presents significant challenges to develop flexible power supplies and sensors that are efficient and convenient, highly sensitive, and adaptable to complex environments. In this study, dual-network ionic PSL hydrogels were successfully synthesized and characterized, which have excellent cyclic tensile properties (maximum stress fluctuation <8 % over 50 tensile times), anti-freezing (-47.2 °C), electrical conductivity (175.

A transposon-based cargo system mediates gene trafficking and creates ultra-clean transgenic plants after stable transformation.

Genetically modified crops have profound impacts on cost savings and environmental friendliness conferred by new traits, such as resistance to insects and herbicides. Selectable marker genes are essential for screening transformed cells, but they are undesirable in the final product due to the risks of horizontal gene transfer and extensive safety assessment requirements. Generating marker- and backbone-free lines can enhance the public acceptance of transgenic crops.

Pharmacokinetic and Pharmacodynamic Study of Folic Acid-Modified Chitosan-Stearic Acid Nanomicelles Loaded with Tetrandrine for Rheumatoid Arthritis.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease, and it is currently incurable. Tetrandrine (TET) has an obvious curative effect with therapeutic efficacy on RA, but its use is limited due to its poor water-solubility and bioavailability. Therefore, TET-loaded nanomicelles modified with chitosan, stearic acid, and folic acid (FCST) was prepared in the study, and the pharmacokinetics and pharmacodynamics were studied.

Erratum: A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body.

[This corrects the article DOI: 10.1016/j.xinn.

ZnO Nanofertilizer Reduced Organic Phosphorus Transformation and Altered Microbial Function in Soil for Sustainable Agriculture.

The impacts of zinc oxide nanoparticles (ZnO NPs) as nanofertilizers on the transformation of phytogenic organic phosphorus (OP), specifically phytic acid (PA) and soy lecithin (LE), as well as their effects on soil microbial functions, remain insufficiently characterized. This study employed a 60-day soil microuniverse experiment to investigate microbial responses to OP under ZnO NPs exposure, focusing on soil physicochemical properties, phosphorus (P) and Zn species transformations, bacterial community and function. At low concentrations (5 and 20 mg/kg), ZnO NPs did not significantly reduce the available P content, but they reduced the transformation of OP into other P species.

Characterization of the upgraded photoinjector at the Chinese Academy of Engineering Physics Terahertz Free Electron Laser Facility.

The Chinese Academy of Engineering Physics Terahertz Free Electron Laser Facility (CAEP THz FEL, CTFEL) has been operated as a user facility for over five years. To further meet the growing demands of modern science, an upgrade project for an infrared-terahertz free electron laser facility based on CTFEL has been proposed to broaden the frequency range from 0.1-4.

Validation of the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) in Western China.

Objective: To translate and validate the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) among Chinese people with epilepsy.

Methods: Adult outpatients from Sichuan Provincial People's Hospital were recruited. The type of anxiety disorder was determined via the Mini International Neuropsychiatric Interview (MINI).

Multiplex one-step RT‒qPCR assays for simultaneous detection of AMDV, MEV and CDV.

Background: Aleutian mink disease, mink viral enteritis and canine distemper are known as the three most serious diseases that cause great economic loss in the mink industry. In clinical practice, aleutian mink disease virus (AMDV), mink enteritis virus (MEV) and canine distemper virus (CDV) are common mixed infections, and they have similar clinical clinical signs, such as diarrhoea. Therefore, a rapid and accurate differential diagnosis method for use on mink ranches is essential for the control of these three pathogens.

Correlation of Phase Structure, Defect Relaxation, and Microwave Dielectric Properties in Low-Loss MgTiO Ceramic Systems.

Low-loss microwave dielectrics are of significant importance for the miniaturization and integration of microwave devices. In this paper, the ceramics of nominal composition MgTiO ( = 3-6) are synthesized, and the correlations among their phase compositions, defect behaviors, and microwave dielectric properties are systematically investigated. The analyses indicate that the MgTiO ceramics are a biphasic system consisting of hexagonal ilmenite-structured MgTiO and cubic spinel-structured MgTiO.

Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.

Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques.

Using apparent diffusion coefficient maps and radiomics to predict pathological grade in upper urinary tract urothelial carcinoma.

Background: The apparent diffusion coefficient (ADC) has been reported as a quantitative biomarker for assessing the aggressiveness of upper urinary tract urothelial carcinoma (UTUC), but it has typically been used only with mean ADC values. This study aims to develop a radiomics model using ADC maps to differentiate UTUC grades by incorporating texture features and to compare its performance with that of mean ADC values.

Methods: A total of 215 patients with histopathologically confirmed UTUC were enrolled retrospectively and divided into training and test sets.

Preparation and Evaluation of Tetrandrine Nanocrystals to Improve Bioavailability.

Background: Tetrandrine (TET) has multiple pharmacological activities, but its water solubility is poor, which is the main reason for its low bioavailability.

Objectives: The purpose of this study was to prepare TET nanocrystals (TET-NCs) using a grinding method to enhance the dissolution rate and ultimately improve the bioavailability of TET.

Methods: TET-NCs were synthesized via media milling, employing Poloxam 407 (P407) as surface stabilizer and mannitol as a cryoprotectant during freeze-drying.

Engineered Pine Endophytic Fungus Expressing dsRNA Targeting Lethal Genes to Control the Plant Parasitic Nematode .

The pine wood nematode (PWN), , is one of the most serious invasive forest pests, responsible for pine wilt disease (PWD). Currently, there are no effective, environmentally friendly control methods available. RNA interference (RNAi) technology has been extensively utilized to screen functional genes in eukaryotes and to explore sustainable pest management approaches through genetic engineering.

Efficient Adsorption of Ionic Liquids in Water Using -SOH-Functionalized MIL-101(Cr): Adsorption Behavior and Mechanism.

With the increasing application of ionic liquids (ILs) in industrial areas, the removal of ILs from aqueous media has attracted considerable attention due to their potential environmental impact. In this study, we investigated the adsorption behavior and removal mechanism of ILs in water using the metal-organic framework material MIL-101(Cr) and its sulfonated derivative MIL-101(Cr)-SOH. It was observed that MIL-101(Cr)-SOH exhibited notably elevated adsorption capacity (1.

Genomic island-encoded LmiA regulates acid resistance and biofilm formation in enterohemorrhagic O157:H7.

Enterohemorrhagic (EHEC) O157:H7 is an important intestinal pathogen that causes severe foodborne diseases. We previously demonstrated that the genomic island-encoded regulator LmiA activates the locus of enterocyte effacement (LEE) genes to promote EHEC O157:H7 adherence and colonization in the host intestine. However, whether LmiA is involved in the regulation of any other biological processes in EHEC O157:H7 remains largely unexplored.