Understanding the impact of expertise on compassion fatigue in counseling via core self-evaluation and resilience.

Compassion fatigue is a prevalent challenge experienced by helping professionals, influencing both their personal well-being and the quality of services they deliver. While the beneficial impact of expertise in counseling on alleviating compassion fatigue has been established, limited research has investigated this association specifically among mental health counselors within the cultural context of China. Additionally, the underlying mechanisms remain unclear.

Dual-targeting galactose-functionalized hyaluronic acid modified lipid nanoparticles delivering silybin for alleviating alcoholic liver injury.

Alcoholic liver injury stands as a predominant pathogenic contributor to the global burden of liver diseases, with alcohol consumption serving as a significant determinant of worldwide morbidity and mortality. Given that liver-targeted therapy for mitigating alcoholic liver injury remains to be a major clinical challenge due to the poor specificity and instability associated with single targeting modification in actively targeted nanomedicine systems, bifunctional targeting modification may serve as a more promising strategy. Here, galactose-functionalized hyaluronic acid (Gal-HA) coated cationic solid lipid nanoparticles carrying silybin (Gal-HA/SIL-SLNPs) featuring dual-targeting hyaluronic acid (HA) and galactose (Gal) moieties, enabled specific liver surface targeting of asialoglycoprotein receptor (ASGPR) and cluster of differentiation 44 (CD44) proteins to enhance silybin uptake, while simultaneously ameliorating the deficiencies of positively charged lipid nanoparticles as drug carriers and preserving their stability in the bloodstream.

Understanding time perspective's influence on academic burnout and achievement in Chinese undergraduates.

University students are highly vulnerable to experiencing academic burnout due to various pressures, necessitating an exploration of its causes and effects. Time perspective theory emphasizes how individuals' perspectives of past, present, and future events shape their behavior. Yet, the relationship between time perspective, burnout, and academic achievement remains unclear.

Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery.

Nimodipine is the primary clinical drug used to treat cerebral vasospasm following subarachnoid hemorrhage. Currently, tablets have low bioavailability when taken orally, and injections contain ethanol. Therefore, we investigated a new method of nimodipine administration, namely, nasoencephalic administration.

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation.

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the microdeletion, bear no obvious connection to translation. Here, we use proteomics, genetics, and translation assays in cultured cells and mouse brain to reveal altered translation mediated by loss of the kinase TAOK2 in deletion models.

Research on quantitative evaluation of digital economy policy in China based on the PMC index model.

The development of digital economy is a strategic choice to grasp the revolution of new science and technology and the new opportunities of industrial reform. The development of digital economy depends on the good support of policy and theoretical system. Therefore, the quantitative evaluation of policy texts provides the basis of decision-making and the suggestions of path optimization for the formulation and improvement of digital economy policy of China.

Transdermal Drug Delivery System of Linagliptin Sustained-release Microparticle Gels: Characterization and Evaluation.

Background: Linagliptin (LNG) exhibits poor bioavailability and numerous side effects, significantly limiting its use. Transdermal drug delivery systems (TDDS) offer a potential solution to overcome the first-pass effect and gastrointestinal reactions associated with oral formulations.

Objective: The aim of this study was to develop LNG microparticle gels to enhance drug bioavailability and mitigate side effects.

Foliar zinc reduced Cd accumulation in grains by inhibiting Cd mobility in the xylem and increasing Cd retention ability in roots.

Cadmium (Cd) pollution endangers the safe utilization of paddy soils, and foliar zinc (Zn) can reduce the toxic effects of Cd. However, little is known about the effects of foliar Zn application on the transport and immobilization of Cd in key rice tissues and the physiological state of rice plants. A pot experiment was conducted to explore the effects of spraying 0.

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants.

Centrosome-dependent microtubule modifications set the conditions for axon formation.

Microtubule (MT) modifications are critical during axon development, with stable MTs populating the axon. How these modifications are spatially coordinated is unclear. Here, via high-resolution microscopy, we show that early developing neurons have fewer somatic acetylated MTs restricted near the centrosome.

Identification of a Novel Immune-Related CpG Methylation Signature to Predict Prognosis in Stage II/III Colorectal Cancer.

With the increasing incidence of colorectal cancer (CRC) and continued difficulty in treating it using immunotherapy, there is an urgent need to identify an effective immune-related biomarker associated with the survival and prognosis of patients with this disease. DNA methylation plays an essential role in maintaining cellular function, and changes in methylation patterns may contribute to the development of autoimmunity, aging, and cancer. In this study, we aimed to identify a novel immune-related methylated signature to aid in predicting the prognosis of patients with CRC.

Comprehensive analysis of immune-related prognostic genes in the tumour microenvironment of hepatocellular carcinoma.

Background: The mortality rate of hepatocellular carcinoma (HCC) remains high worldwide despite surgery and chemotherapy. Immunotherapy is a promising treatment for the rapidly expanding HCC spectrum. Therefore, it is necessary to further explore the immune-related characteristics of the tumour microenvironment (TME), which plays a vital role in tumour initiation and progression.

Foliar application of Zn reduces Cd accumulation in grains of late rice by regulating the antioxidant system, enhancing Cd chelation onto cell wall of leaves, and inhibiting Cd translocation in rice.

Paddy soil contaminated by cadmium (Cd) has attracted worldwide attention, while foliar spraying of zinc (Zn) could be considered a cost-effective and practical agronomic measure for reducing Cd accumulation in rice grain. However, the effects due to foliar spraying of Zn on different cultivars, as well as the mechanism of subsequent processes taking place are not fully understood up to now. To go a step ahead, a field experiment was conducted with the aim of studying the capability of foliar application of Zn (0.

[Zonation on non-point source pollution risk in the lower reaches of Zijiang River based on the "source-sink" theory].

Non-point source pollution risk assessment and zonation research are of great significance for the eco-environmental protection and optimization of land use structure. We identified the "source" and "sink" landscape using the "source-sink" landscape pattern theory based on the two phases of land use data in the lower reaches of Zijiang River in 2010 and 2018. We comprehensively considered the non-point source pollution occurrence and migration factors, and used location-weighted landscape contrast index (LCI) and non-point source pollution load index (NPPRI) to analyze non-point source pollution risk spatio-temporal characteristics in the study area.

A P53-related microRNA model for predicting the prognosis of hepatocellular carcinoma patients.

Studies have shown that microRNAs (miRNAs) play a vital role in tumor progression and patients' prognosis. Therefore, we aimed to construct a miRNA model for forecasting the survival of hepatocellular carcinoma (HCC) patients. The gene expression data of 433 patients with HCC from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus public databases were remined by survival analysis and receptor manipulation characteristic curve (ROC).

Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation.

Adult human mesenchymal stem cells have the potential to differentiate into osteoblast, which plays crucial roles in bone regeneration and repair. Some transcriptional factors (TFs), such as BMP-2 and RUNX2, have been demonstrated to control the differentiation processes. It is important to discover more key regulators in osteoblast differentiation.

Comprehensive analysis of lncRNA-TF crosstalks and identification of prognostic regulatory feedback loops of glioblastoma using lncRNA/TF-mediated ceRNA network.

Glioblastoma (GBM) has become the most aggressive primary brain tumor in the world. Patients with GBM usually have a poor prognosis. The median survival times of GBM patients retain less than 2 years.

Analysing the Motions of Spray Droplets on a Cow's Surface to Relieve Heat Stress.

Exploring the behaviour of sprayed water droplets on dairy cow hair during the spraying process is of great significance to improve the effects of this process on cooling a dairy cow's body. In this paper, we use a high-speed camera to examine the sprayed droplets of different diameters and then analyse the experimental results. The results show that the movements of sprayed droplets on the simulated dairy cow (SDC) surface can be divided into four categories: random scattering, aggregation, multiple deformations and flow slipping.

Effectiveness of simultaneous foliar application of Zn and Mn or P to reduce Cd concentration in rice grains: a field study.

Excess cadmium (Cd) in agricultural soils can be taken up by rice plants and concentrated in the grain, presenting a human health risk. In this study, we field tested the effects of three foliar treatments (zinc (Zn) alone, or combined with manganese (ZnMn) or phosphorus (ZnP)) on the Cd concentration and grain yield of six rice cultivars (C Liangyou 7, Fengyuanyou 272, Xiangwanxian 12, Tianyouhuazhan, Xiangwanxian 13, and Jinyou 284) at the grain filling stage. Our results showed that rice yield and Cd, Zn, Mn, P, and K concentrations were significantly different among the cultivars (p < 0.

A novel multidimensional signature predicts prognosis in hepatocellular carcinoma patients.

The abnormal expression of microRNAs (miRNAs) or protein-coding genes (PCGs) have been found to be associated with the prognosis of hepatocellular carcinoma (HCC) patients. Using bioinformatics analysis methods including Cox's proportional hazards regression analysis, the random survival forest algorithm, Kaplan-Meier, and receiver operating characteristic (ROC) curve analysis, we mined the gene expression profiles of 469 HCC patients from The Cancer Genome Atlas (n = 379) and Gene Expression Omnibus (GSE14520; n = 90) public database. We selected a signature comprising one protein-coding gene (PCG; DNA polymerase μ) and three miRNAs (hsa-miR-149-5p, hsa-miR-424-5p, hsa-miR-579-5p) with highest accurate prediction (area under the ROC curve [AUC] = 0.

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.

Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV infection have not been fully elucidated, and effective therapeutics are not currently available. Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in response to ZIKV infection and that its enzymatic product, 25-hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV.

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.

The link between Zika virus (ZIKV) infection and microcephaly has raised urgent global alarm. The historical African ZIKV MR766 was recently shown to infect cultured human neural precursor cells (NPCs), but unlike the contemporary ZIKV strains, it is not believed to cause microcephaly. Here we investigated whether the Asian ZIKV strain SZ01 could infect NPCs in vivo and affect brain development.