Design and experimental research of orbital angular momentum multiplexing holography based on optical diffraction neural network.

The orbital angular momentum (OAM) multiplexing holography has the advantages of large information capacity and high security, and has important application value in holographic storage, optical encryption, and optical computing. However, as the number of multiplexing channels increases, this technology suffers from deterioration in image quality, which limits its application scope. This article proposes an innovative design that introduces an optical diffractive neural network (ODNN) into OAM multiplexing holography, establishes a scientific image quality evaluation function, applies an end-to-end optimization method, and designs OAM multiplexing holograms in parallel, significantly improving the image quality of OAM holography.

Wavelength-polarization-multiplexed multichannel perfect vortex array generator based on dielectric metasurface.

The multi-channel perfect vortex (PV) array based on metasurface has important applications in optical communication, particle manipulation, quantum optics, and other fields due to its ultra-thin structure and excellent wavefront control ability. However, it is very challenging to utilize a single metasurface to simultaneously achieve independent channel PV arrays at different wavelengths with low crosstalk and low structural complexity. Here, we propose and design a single rectangular structured metasurface based on TiO, achieving a multi-channel PV beam array with dual-wavelength and dual-polarization multiplexing.

Intuitionistic fuzzy-based entropy weight method-TOPSIS for multi-attribute group decision-making in drilling fluid waste treatment technology selection.

Drilling fluid waste is produced by oil and gas industry operations and can potentially cause serious environmental pollution and energy consumption if not properly treated. Currently, there are several treatment methods available for drilling fluid waste such as bioremediation, thermal treatment, solidification/stabilization treatment, electrochemical remediation, physiochemical treatment, and supercritical fluid treatment. However, selecting an adequate method to treat drilling fluid waste is a critical consideration.

Evaluation of HER-2 positive breast cancer treated with dual-targeted treatment of trastuzumab plus pertuzumab.

Clinical studies have shown that trastuzumab combined with pertuzumab (dual-targeted drug therapy) can significantly improve the treatment status and prognosis of HER-2 positive breast cancer patients through double targeting of HER-2. This study systematically evaluated the efficacy and safety of trastuzumab combined with pertuzumab in the treatment of HER-2 positive breast cancer. We search relevant databases and collect RCTs on the treatment of HER-2 positive breast cancer with dual-targeted treatment.

Biomarkers of related driver genes predict anti-tumor efficacy of immune checkpoint inhibitors.

Cancer is a disease with high morbidity and mortality in the world. In the past, the main treatment methods for cancer patients were surgery, radiotherapy and chemotherapy. However, with early treatment, the recurrence rate of cancer is higher, and the drug resistance of cancer cells is faster.

Survival Prediction of Patients Treated With Immune Checkpoint Inhibitors KRAS/TP53/EGFR-Single Gene Mutation.

Immune checkpoint inhibitors (ICIs) have become an effective treatment option for cancer. KRAS, EGFR and TP53 are common mutated oncogenes in cancer whose single gene status may predict the therapeutic effect of clinical ICIs. In this efficacy evaluation, we aimed to clarify whether the single gene mutation status of KRAS, EGFR or TP53 affects the survival benefits of ICIs in cancer patients.

Effects of Concomitant Antibiotics Use on Immune Checkpoint Inhibitor Efficacy in Cancer Patients.

Objective: Immune checkpoint inhibitors (ICIs) have changed the outcomes of a variety of cancers in an unprecedented manner. Gut microbiome plays a crucial regulatory role in the antineoplastic therapy of ICIs, which can be influenced by antibiotic (ABX) administration. In this efficacy evaluation, we aimed to clarify the correlations of ABX administration with the survival of cancer patients receiving ICIs treatment.

Application of interval-valued Pythagorean fuzzy VIKOR approach for petroleum sludge treatment technology evaluation and selection.

Petroleum sludge is produced during oilfield development and production and can negatively impact the production area and surrounding environment. With increasing attention to the environmental protection of oilfields, finding an energy-efficient, environmentally sound, cost-effective and socially acceptable sludge treatment method is crucial to the sustainable development of oil companies. However, there are several problems in the selection process: ① there is no effective index system for the evaluation of treatment technologies; ② there is data uncertainty and loss of information; ③ experts in the field often make one-sided decisions; and ④ the common decision models fail to balance the general effect and local dominance of a treatment technology.

Sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia: a systematic review and meta-analysis of randomized controlled trials.

Purpose: To systematically compare the efficacy and safety of sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia (CSEA), a systematic review and meta-analysis of randomized controlled trials targeting parturients requesting labor analgesia was conducted.

Methods: The primary outcome measure was visual analog scale scores assessed at 10, 15, 30, and 60 min after intrathecal injection. Secondary outcomes included duration of spinal analgesia, incidence of side effects in parturients, and neonatal Apgar scores.

Clinical Consumption of Opioid Analgesics in China: A Retrospective Analysis of the National and Regional Data 2006-2016.

Context: The annual consumption of opioid analgesics in the U.S. was more than 10 times the world average, whereas that in China was at a moderate level within Asia but much lower than the worldwide average.

Synthesis of Fe-FeO/rGO Composite with Heterostructure Through Room-Temperature Reduction as Photo-Fenton Catalyst.

A Fe-Fe₃O₄/rGO nanocomposite with heterostructure has been successfully synthesized by a highyield, low-cost, and easily operated room-temperature reduction method. The novel Fe-Fe₃O₄/rGO composite exhibits an excellent activity for the degradation of Orange II under visible light by the Photo-Fenton process, which is 92.06% after 180 minutes.

Microencapsulation of Lefty-secreting engineered cells for pulmonary fibrosis therapy in mice.

Idiopathic pulmonary fibrosis (IPF) is a progressive disease that causes unremitting deposition of extracellular matrix proteins, thus resulting in distortion of the pulmonary architecture and impaired gas exchange. Associated with high morbidity and mortality, IPF is generally refractory to current pharmacological therapies. Lefty A, a potent inhibitor of transforming growth factor-β signaling, has been shown to have promising antifibrotic ability in vitro for the treatment of renal fibrosis and other potential organ fibroses.

A novel double-targeted nondrug delivery system for targeting cancer stem cells.

Instead of killing cancer stem cells (CSCs), the conventional chemotherapy used for cancer treatment promotes the enrichment of CSCs, which are responsible for tumor growth, metastasis, and recurrence. However, most therapeutic agents are only able to kill a small proportion of CSCs by targeting one or two cell surface markers or dysregulated CSC pathways, which are usually shared with normal stem cells (NSCs). In this study, we developed a novel nondrug delivery system for the dual targeting of CSCs by conjugating hyaluronic acid (HA) and grafting the doublecortin-like kinase 1 (DCLK1) monoclonal antibody to the surface of poly(ethylene glycol) (PEG)-poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs), which can specifically target CD44 receptors and the DCLK1 surface marker - the latter was shown to possess the capacity to distinguish between CSCSs and NSCs.

Cloud-based decision framework for waste-to-energy plant site selection - A case study from China.

Waste-to-energy (WtE) plant site selection is crucially important during the whole life cycle. Currently, the scholars launch some research in the WtE plant site selection. However, there are still two great problems in the present methods.