Publications by authors named "Shuai Fu"

Background: The goal of on-demand treatment for hereditary angioedema attacks is to halt attack progression to minimize morbidity and mortality. Four on-demand treatments have been approved thus far (ecallantide, icatibant, recombinant human C1 esterase inhibitor [rhC1INH], and plasma-derived C1INH). Results from the sebetralstat phase 3 KONFIDENT trial (NCT05259917) have been reported.

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Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, and which risk factors mediate this causal relationship remains unknown.

Methods: The intelligence (n=269,867), noncognitive education (n=510,795) and cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals of European ethnicities. The genetic associations between these factors and urinary tract or kidney infection (UK Biobank, n=397,867) were analyzed using linkage disequilibrium score regression.

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Background: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir (RDV), a broad-spectrum antiviral. Given the evolving nature of COVID-19, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review (SLR) with meta-analysis (MA) to summarize RDV effectiveness among hospitalized adults.

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Charge/energy separation across interfaces of plasmonic materials is vital for minimizing plasmonic losses and enhancing their performance in photochemical and optoelectronic applications. While heterostructures combining plasmonic two-dimensional transition metal carbides/nitrides (MXenes) and semiconducting transition metal dichalcogenides (TMDs) hold significant potential, the mechanisms governing plasmon-induced carrier dynamics at these interfaces remain elusive. Here, we uncover a distinctive secondary excitation phenomenon and an ultrafast charge/energy transfer process in heterostructure films composed of macro-scale TiCT and MoS films.

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Covalent organic frameworks are an emerging class of covalently linked polymers with programmable lattices and well-defined nanopores. Developing covalent organic frameworks with both high porosity and excellent charge transport properties is crucial for widespread applications, including sensing, catalysis, and organic electronics. However, achieving the combination of both features remains challenging due to the lack of overarching structure-property correlations.

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Lightweight, hierarchical thin-walled tubes are essential in aerospace and transportation for their exceptional impact resistance and energy absorption capabilities. This study applies bionic design principles to revolutionize traditional thin-walled tube structures, enhancing their energy absorption performance. Inspired by natural models-spider webs, beetle elytra, cuttlebone, and spiral wood fibers-integrated bionic hierarchical thin-walled tubes (IBHTTs) with diverse bionic structural and material combinations are developed using additive manufacturing.

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Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as an intriguing class of quantum materials due to their high crystallinity, persistent spin centers, and tunable structures and topologies. However, it remains unclear how to achieve long spin relaxation time at room temperature in 2D c-MOFs via a bottom-up design strategy. Herein, we design a hexahydroxytrithiatruxene ligand (HHTH) to minimize the influence of nuclear spin on electron spin relaxation while weakening -π conjugation to construct a "spin docking" for preserving spin centers, which enables the resulting 2D c-MOFs, NiHHTH, to exhibit quantum coherence and Rabi oscillations at room temperature.

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In this study, a new versatile fluorescent probe, YH (N, N-((1E, 1'E)-((phenylazanediyl)bis(4, 1-phenylene))bis(methanylylidene))di(picolinohydrazide)), was created and synthesized. YH demonstrated the capability to continuously detect Cu and PO in EtOH/HEPES solutions (95/5, V/V, HEPES = 10 mmol, pH = 7.4).

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Objective: Phototherapy is the standard treatment, but its efficacy can vary among neonates, prompting interest in genetic factors, particularly UGT1A1 gene variants. This study aims to evaluate the clinical significance of the UGT1A1 gene variant in influencing phototherapy response and long-term outcomes in neonatal hyperbilirubinemia.

Methods: This retrospective study included 104 neonates with neonatal hyperbilirubinemia, of whom 63 carried the normal UGT1A1 gene, and 41 had the homozygous UGT1A1 Gly71Arg variant.

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Urban development leads to frequent changes in land use, which leads to temporal and spatial variation of carbon emissions. In this study, land use change data, economic and social data, and energy consumption data of Nanchang City from 2000 to 2020 were used to estimate the spatio-temporal evolution of carbon emissions in Nanchang City, and the LMDI model was used to identify the main driving factors affecting the change of carbon emissions in Nanchang City. It is found that from 2000 to 2020, the carbon emission of Nanchang City has a great change, showing a "parabolic" change law, that is, rising first and then decreasing.

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, a medicinal herbaceous plant documented in the Chinese Pharmacopoeia, is a promising candidate for research into plant-derived pharmaceuticals. However, the study of newly emerging viruses that threaten the cultivation of remains limited. In this study, plants exhibiting symptoms such as leaf yellowing, mottled leaves, and vein chlorosis were collected and subjected to RNA sequencing to identify potential viral pathogens.

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Conjugated coordination polymers (c-CPs), a novel class of organic-inorganic hybrid materials, are distinguished by their unique structural characteristics and exceptional charge transport properties. The electronic properties of these materials are critically determined by the constituting coordination atoms, with electron-rich selenol ligands emerging as promising candidates for constructing high-mobility semiconducting c-CPs. Despite their potential, c-CPs incorporating selenium-substituted ligands remain scarce due to the synthetic challenges associated with both the ligands and the coordination polymers.

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Background: Maintenance hemodialysis (MHD) is an effective treatment for patients with end-stage renal disease. Although MHD can prolong the survival of patients, their quality of life is lower and the fatality rate is higher. This work analyzed the factors related to the autogenous arteriovenous fistula (AVF)-like expansion of non-diabetic MHD patients by vascular ultrasound (VUS).

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A novel coumarin-based fluorescent probe LY was designed and synthesized in this work. LY could selectively recognize Cu via fluorescence quenching at 522 nm in a DMSO/HO solution. The recognition process experienced minimal interference from other common cations.

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This research seeks to investigate the function and fundamental mechanisms of Itchy E3 ubiquitin ligase (ITCH), a HECT (homologous to E6AP carboxyl terminus)-type E3 ubiquitin ligase, in endothelial ferroptosis, particularly in the context of atherosclerosis, which has been underexplored. The levels of ITCH protein in the aortas of mice with atherosclerosis were analyzed. Constructs for ITCH RNA interference were generated and introduced into human aortic endothelial cells (HAECs).

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Objectives: Surveillance of rectal cancer recurrence in patients with negative pretreatment carcinoembryonic antigen (CEA) is challenging. This study aimed to develop the magnetic resonance imaging (MRI)-based radiomics models to predict rectal cancer recurrence in CEA-negative patients.

Materials And Methods: This retrospective multicenter study consecutively enrolled rectal cancer patients with negative pretreatment CEA diagnosed between November 2012 and November 2018 from three medical centers.

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Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) are emerging as promising electrode materials for electrochemical energy storage devices. However, a viable path to realize superior dual-ion storage in 2D c-MOFs has remained elusive. Here, we report the synthesis of Cu(N-OHPTP) 2D c-MOFs (x=0,1,2; OHPTP=octahydroxyphenanthrotriphenylene) with precise aromatic carbon-nitrogen arrangements, based on the π-conjugated OHPTP ligand incorporated with one or two nitrogen atoms.

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Ultrasound enhancing agents (UEAs), including OPTISON, DEFINITY, and LUMASON, enhance the diagnostic performance of echocardiography, particularly, in patients with suboptimal acoustic windows. However, there remains a paucity of comparative safety assessments among the Food and Drug Administration-approved UEAs. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic literature review performed in August 2023 searched Medline, Embase, Cochrane Library, and gray literature.

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Ligularia jaluensis is an important medicinal and ornamental plant in China. However, the viruses capable of infecting Ligularia jaluensis remains unknown. Here, we identified a novel carlavirus, tentatively named ligularia jaluensis carlavirus (LJCV), as well as a known iris severe mosaic virus (ISMV), in L.

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Objective: To explore the sub-regional histogram features of amide proton transfer-weighted (APTw) MRI, compared with those of diffusion-weighted imaging (DWI), in predicting the tumor budding (TB) grade of rectal cancer (RC).

Materials And Methods: This study prospectively enrolled 74 patients with pathologically confirmed RC, who underwent APTw MRI before surgery from July 2022 to March 2023. Hematoxylin-eosin staining was used for TB scoring.

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Granulomatous lobular mastitis (GLM) is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by significant pain and a high propensity for recurrence, the incidence rate has gradually increased, and has become a serious breast disease that should not be ignored. GLM is highly suspected relative to microbial infections, especially those of Corynebacterium species; however, the mechanisms involved are unclear, and prevention and treatment are difficult. In this study, we demonstrated the pathogenicity of Corynebacterium parakroppenstedtii in GLM using Koch's postulates.

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Article Synopsis
  • Electrochemical activation of CO for sustainable C2 product synthesis is challenging but essential for reducing CO emissions.
  • A novel method using electron-beam irradiation produces metal-organic frameworks (MOFs) with efficient Lewis pairs, achieving 70.0% faradic efficiency for C2 products.
  • The study enhances understanding of CO activation mechanisms and showcases the potential of Lewis pair-site MOFs in CO electrochemical conversion.
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Hyperspectral video provides rich spatial and spectral information, which is crucial for object tracking in complex scenarios. Despite extensive research, existing methods often face an inherent trade-off between rich spectral information and redundant noisy information. This dilemma arises from the efficient utilization of hyperspectral image data channels.

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Article Synopsis
  • * A new system called the cortical organoid lineage-tracing (COR-LT) allows researchers to track and identify neuron origin from various progenitor cells in lab-grown brain-like structures.
  • * Findings reveal that most excitatory neurons in these organoids come from intermediate progenitor cells, and a specific genetic variant linked to autism affects the types and characteristics of neurons produced, highlighting the role of progenitor subtypes in brain diversity.
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A novel and highly efficient photocatalyst of a AgBiO/BiOCl heterojunction has been developed via a facile water bath and in situ precipitation method. The photocatalytic activities of the catalysts were investigated by the degradation of ciprofloxacin (CIP) under visible-light irradiation (>420 nm). The experiment results revealed that the photocatalytic performance of the optimized AgBiO/BiOCl heterojunction was much higher than pure AgBiO and BiOCl.

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