Comp Biochem Physiol C Toxicol Pharmacol
March 2025
The atmospheric oxygen concentration is significantly reduced in highland regions compared to lowland areas. The first entering the plateau can induce sleep disorders in individuals, primarily attributed to insufficient oxygen supply. This study used Drosophila melanogaster as a model organism to better understand the molecular mechanism of acute hypoxia-induced sleep disorders.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is an age-related neurological illness that poses a significant hazard to human health. A fat-soluble compound called tanshinones was isolated from Danshen, a traditional Chinese herb. Recent years have seen reports of clinical trials examining the effects of tanshinones on cognitive impairment among individuals with AD, as well as the publication of pertinent basic research.
View Article and Find Full Text PDFElectrode-electrolyte interphases are critical determinants of the reversibility and longevity of lithium (Li)-metal batteries (LMBs). However, upon cycling, the inherently delicate interphases, formed from electrolyte decomposition, become vulnerable to chemomechanical degradation and corrosion, resulting in rapid capacity loss and thus short battery life. Here, we present a comprehensive analysis of the complex interplay between the thermodynamic and kinetic properties of interphases on Li-metal anodes, providing insights into interphase design to address these challenges.
View Article and Find Full Text PDFDiurnal light-dark cycles regulate nutrient uptake and transport; however, the underlying molecular mechanisms remain largely unknown. Transcription factor MYB59 and ion transporter NPF7.3 participate in root-to-shoot K/NO translocation in Arabidopsis.
View Article and Find Full Text PDFIn graminaceous plants, nodes play vital roles in nutrient allocation, especially for preferential nutrient distribution to developing leaves and reproductive organs. However, the molecular mechanisms underlying this distribution remain poorly understood. In this study, we identified a transporter named ZmNPF7.
View Article and Find Full Text PDFAmmonia (NH) plays a crucial role in the global nitrogen cycle, the increased NH emissions from agricultural activities impacting air, soil, water quality, and human health. Accurately estimating both the vertical and horizontal transport distances of NH are important for effective pollution control. Therefore, we used a helium-filled balloon mounted sampler to analyze the vertical profiles of NH emissions and their seasonal variations in an agricultural area of southeast China.
View Article and Find Full Text PDFObjective: To assess the short-term outcomes of the transaortic modified Morrow procedure when performed via a minimally invasive right infra-axillary incision.
Methods: We conducted a retrospective observational study at a single center of patients diagnosed with hypertrophic obstructive cardiomyopathy from September 2021 to July 2023.
Results: The cohort comprised 148 patients (mean age 47.
Objective: To review the most common types of primary and secondary headaches that are associated with Sjogren's disease (SjD).
Background: Sjogren's disease is a chronic systemic autoimmune disease that typically presents with xerophthalmia, xerostomia, and arthralgias. Sensory and motor neuropathies are commonly reported neurological complications with SjD.
water (HW) has a wide range of applications in the new food service industry. However, few process and flavor studies have been conducted on HW. The aim of this study was to investigate the effect of boiling process on HW flavor as well as the mechanisms by which important aroma compounds affect the flavor.
View Article and Find Full Text PDFObjective: This study aims to assess the safety, efficacy, and esthetic outcomes of an innovative 4 cm right infra-axillary incision approach for concomitant ascending aorta and aortic valve replacement (AAR and AVR), with a specific focus on achieving optimal surgical outcomes while ensuring minimal visible scarring.
Methods: We retrospectively examined all elective cases of concomitant AAR and AVR surgery performed at our institution from July 2021 to June 2023. Exclusions encompassed emergency surgery, acute type A aortic dissection, active aortic valve endocarditis, redo cardiac surgery, the necessity for concurrent mitral valve replacement, or left ventricular assist device implantation.
Background: Astragalus membranaceus has shown positive clinical efficacy in treating colorectal cancer (CRC).
Objective: This study aimed to identify the key active components of Astragalus and determine effective targets of these components in CRC patients.
Methods: We identified active components of Astragalus membranaceus and differentially expressed genes in traditional Chinese medicine systems pharmacology database and The Cancer Genome Atlas.
Microtubule-based vesicle trafficking usually relies upon kinesin and dynein motors and few reports describe microtubule polymerisation driving directional vesicle trafficking. Here we show that Arabidopsis END BINDING1b (EB1b), a microtubule plus-end binding protein, directly interacts with SYP121, a SNARE protein that mediates the trafficking of the K channel KAT1 and its distribution to the plasma membrane (PM) in Arabidopsis guard cells. Knockout of AtEB1b and its homologous proteins results in a modest but significant change in the distribution of KAT1 and SYP121 in guard cells and consequently delays light-induced stomatal opening.
View Article and Find Full Text PDFLithium (Li) metal anodes are considered one of the most promising anodes for high-performance batteries with ultra-high specific energy density. However, uncontrolled dendrite growth and the unsuitability of common systems for high voltage hinder the development of Li metal batteries with long cycle life. Herein, we report a rationally designed artificial solid electrolyte interphase (SEI) for Li metal anodes, incorporating LiNO and lithium difluoro(oxalato)borate (LiDFOB) as additives within a porous poly (vinylidene fluoride--hexafluoropropylene) (PVDF-HFP) polymer skeleton (referred to as PNF).
View Article and Find Full Text PDFDigital light processing (DLP) bioprinting, known for its high resolution and speed, enables the precise spatial arrangement of biomaterials and has become integral to advancing tissue engineering and regenerative medicine. Nevertheless, inherent light scattering presents significant challenges to the fidelity of the manufactured structures. Herein, we introduce a photoinhibition strategy based on Rutin nanoparticles (Rnps), attenuating the scattering effect through concurrent photoabsorption and free radical reaction.
View Article and Find Full Text PDFPurpose: The purpose of this study was to compare 3 intraoperative modalities to determine the best and most convenient one for pain control for uniportal lung surgery. This study compared general anesthesia with serratus plane block, general anesthesia with epidural, and general anesthesia alone to examine postoperative pain scores in patients.
Methods: Eighty patients were enrolled and statistically analyzed.
Here, we have synthesized six dihydroxyl-functionalized ionic liquids for phase behavior studies at low temperature crystallographic methods, Raman spectroscopy, differential scanning calorimetry (DSC), and density functional theory (DFT) calculations. Phase varieties are observed depending on the direction and strength of hydrogen bonding. Our studies also show that the ILs could be potentially excellent phase-change thermal storage materials with nearly no change of the phase transition enthalpy.
View Article and Find Full Text PDFIn recent years, China has adopted numerous policies and regulations to control NO emissions to further alleviate the adverse impacts of NO-N deposition. However, the variation in wet NO-N deposition under such policies is not clear. In this study, the southeastern area, with highly developed industries and traditional agriculture, was selected to explore the variation in NO-N deposition and its sources changes after such air pollution control through field observation and isotope tracing.
View Article and Find Full Text PDFBy modulating stomatal opening and closure, plants control gas exchange, water loss, and photosynthesis in response to various environmental signals. During light-induced stomatal opening, the transport of ions and solutes across the plasma membrane (PM) of the surrounding guard cells results in an increase in turgor pressure, leading to cell swelling. Simultaneously, vesicles for exocytosis are delivered via membrane trafficking to compensate for the enlarged cell surface area and maintain an appropriate ion-channel density in the PM.
View Article and Find Full Text PDFBackground: Chronic heart failure (CHF) has always posed a significant threat to human survival and health. The efficacy of thiamine supplementation in CHF patients remains uncertain.
Hypothesis: Receiving supplementary thiamine may not confer benefits to patients with CHF.
Iron-dependent anaerobic oxidation of methane (iron-AOM) has recently been reported to occur in paddy soils, but its actual role and regulation remain unclear. Here, we confirmed the occurrence of iron-AOM at different layers of paddy soils (0-10 cm, 10-20 cm, and 30-40 cm) across tillering, elongation, flowering, and ripening periods under three long-term fertilizer management schemes (CK-unamended, CF-chemical fertilizer, and CFS-chemical fertilizer with straw). The iron-AOM activity contributed 41 % to total AOM, which was greater than that of nitrite- (32 %) and nitrate-AOM (27 %).
View Article and Find Full Text PDFIntroduction: Prolonged disorders of consciousness (pDoC) are a catastrophic condition following brain injury with few therapeutic options. Transcutaneous auricular vagal nerve stimulation (taVNS), a safe, non-invasive intervention modulating thalamo-cortical connectivity and brain function, is a possible treatment option of pDoC. We developed a protocol for a randomised controlled study to evaluate the effectiveness of taVNS on consciousness recovery in patients with pDoC (TAVREC).
View Article and Find Full Text PDFStraw incorporation holds significant promise for enhancing soil fertility and mitigating air pollution stemming from straw burning. However, this practice concurrently elevates the production and emission of methane (CH) from paddy ecosystems. Despite its environmental impact, the precise mechanisms behind the heightened CH production resulting from long-term straw incorporation remain elusive.
View Article and Find Full Text PDFObjective: The mechanism of left ventricular outflow tract obstruction (LVOTO) is complex in hypertrophic cardiomyopathy (HCM). We aimed to evaluate the impact of mitral valve geometry on LVOTO by echocardiography.
Materials And Methods: The study population comprised 177 consecutive patients with HCM.