Publications by authors named "ShuTing Li"

Background: The long-term health effects of fine particulate matter (PM) on hypertension remain incomprehensive. We evaluated the relationship of PM and its components with hypertension incidence in middle-aged and elderly adults.

Methods: We utilised data from the China Health and Retirement Longitudinal Study collected between 2011 and 2018.

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Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed a multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloyl (GelMA), Panax notoginseng saponins (PNS), and sodium alginate microspheres encapsulating insulin-like growth factor-1 (IGF-1). This hydrogel was engineered to achieve gradient and sustained release of bioactive agents to target senescence and promote vascular repair.

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Background: Leptospirosis, a zoonotic disease caused by pathogenic species of the genus Leptospira, is an important public health concern globally. Leptospirosis has been notifiable under statute in China since 1955, and its epidemiological characteristics have evolved during near 70 years. This study aimed to describe the spatial and temporal patterns and demographic characteristics of leptospirosis from 1955 to 2022 in China, and explore the possible factors that influence leptospirosis transmission risk.

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HSCT has been recognized as a successful treatment for various hematological disease. The 5-year survival rate for children and adolescents diagnosed with hematological disease has risen to over 90% in high-income countries. Nevertheless, it has been reported that between 65 and 84% of individuals who undergo HSCT suffer from premature ovarian failure(POF), with only 0.

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To explore the additional value of shear wave elastography (SWE) in chronic obstructive pulmonary disease (COPD) patients. Ultrasound elastography of the rectus femoris and patellar tendon was performed to determine the mean elasticity index (SWE) of the rectus femoris (SWE) and patellar tendon (SWE) in 56 patients with COPD and 53 healthy controls. Clinical tests included the COPD Assessment Test (CAT), the dyspnea index score (modified British Medical Research Council (mMRC)score), the Five-Repetition Sit-to-Stand Test(5STS) and the Six-Minute Walk Test (6MWT).

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Theory of mind (ToM), the ability to attribute mental states to others, is fundamental to human socio-cognition. In child development, a full or explicit understanding of false beliefs (FB) and their impact on action emerges around the age of 4 years. There is evidence of functional specialization of right hemispheric activity related to FB processing in adults and children.

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The biguanide metformin attenuates mitochondrial oxidation and is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation and fatty acid β-oxidation (FAO) in a subgroup of patients with breast cancer (BC) after metformin therapy. Considering that FAO can activate Src kinase in aggressive triple-negative BC (TNBC), we postulate that low-dose biguanide-driven AMPK-ACC-FAO signaling may activate the Src pathway in TNBC.

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Background & Aims: Whether and how socioeconomic status (SES) influences the associations between type 2 diabetes mellitus (T2DM) and lactation remains unknown. We aimed to evaluate the associations between lactation duration and T2DM from a perspective of SES disparity.

Methods: A total of 263,859 parous women without diabetes at baseline (2004-2008) in the China Kadoorie Biobank were included.

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Cantaloupe seed protein isolate (CSPI) has attracted the attention of its low cost, easy digestion and balanced composition of essential amino acids. However, due to the low solubility of CSPI, its application in the food industry is limited. Therefore, the present study investigated the effect of ultrasound-assisted phosphorylation on the solubility of CSPI and the structural properties were characterized.

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Thermodynamic therapy (TDT) is a promising alternative to photodynamic therapy (PDT) by absorbing heat through thermosensitive agents (TSAs) to generate oxygen-irrelevant highly toxic free radicals. Therefore, TDT can be a perfect partner for photothermal therapy (PTT) to achieve efficient synergistic treatment of anoxic tumors using a single laser, greatly simplifying the treatment process and overcoming hypoxia limitations. However, the issues of how to improve the stability and delivery efficiency of TSAs still need to be addressed urgently.

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Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, suggesting separate mechanisms are involved. Here, we found that the transcription factor Casz1 was crucial for early IHC fate consolidation and for OHC survival during mouse development. Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production.

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This systematic review and meta-analysis aimed to quantify the effect of exercise interventions on blood pressure (BP) among children and adolescents with overweight or obesity. A systematic search of five databases was conducted from inception to July 26, 2024, to identify relevant randomized controlled trials (RCTs). Study quality was assessed using the revised Cochrane Risk of Bias Tool for randomized controlled trials.

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Tree peony seeds, traditionally used for edible oil production, are rich in α-linolenic acid (ALA). However, little attention is paid to their development as a healthcare food due to their bitter and astringent taste. The aim of this study was to optimize the debittering process of peony seeds on the basis of maintaining nutritional value and to identify the compounds that cause the taste of bitterness.

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Objectives: We present a new low-dose CT reconstruction method using sub-pixel and anisotropic diffusion.

Methods: The sub-pixel intensity values and their second-order differences were obtained using linear interpolation techniques, and the new gradient information was then embedded into an anisotropic diffusion process, which was introduced into a penalty-weighted least squares model to reduce the noise in low-dose CT projection data. The high-quality CT image was finally reconstructed using the classical filtered back-projection (FBP) algorithm from the estimated data.

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The quest for stable and high-performance photocatalysts is pivotal in advancing the field of photocatalytic CO reduction. Traditional single-component semiconductors are often impeded by their inability to concurrently achieve a broad light absorption spectrum, efficient separation of photogenerated charge carriers, and enduring stability, thereby constraining their photocatalytic efficacy. In this study, we introduce an innovative hm-CN/CdS heterojunction that broadens the light absorption spectrum and significantly enhances the separation efficiency of photogenerated charge carriers.

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Franch. is a native species in southwestern China, characterized by high polymorphism. However, the environmental drivers of intraspecific variation in its functional traits remain poorly understood.

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Nitric oxide (NO) is a key signaling molecule that regulates energy metabolism, apoptosis, and antioxidant balance within mitochondria. It is closely associated with the development of cardiovascular diseases, neurodegenerative diseases, and cancer. Therefore, developing fluorescent probes capable of accurately detecting NO levels in mitochondria is essential for understanding disease mechanisms and clinical diagnostics.

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Per- and polyfluoroalkyl substances (PFASs), a class of ubiquitous and emerging environmental pollutants, have garnered considerable attention due to the scarcity of knowledge regarding their atmospheric sources and the associated human health risks from aerosol exposure. This study investigated the spatial-temporal distribution and potential sources of PFASs in Nanjing city of eastern China by collecting 66 PM samples from industrial, urban, and rural areas between July 2022 and August 2023. Employing ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), 21 distinct PFASs were detected with concentrations ranging from 9.

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Article Synopsis
  • - The study examined the perspectives of endurance athletes and coaches on recovery strategies, looking at their usage across competitive levels, and identifying common barriers to effective recovery.
  • - Athletes primarily favored hydration, hot showers, and carbohydrates, while coaches preferred warm-down/cooling, hydration, and extra protein; both groups agreed that hydration is the most important and effective recovery method.
  • - Significant barriers to implementing recovery strategies included insufficient time, limited knowledge, lack of resources, and skepticism about the benefits of these strategies.
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  • Black carbon (BC), a pollutant from fossil fuel and biomass combustion, significantly affects climate, air quality, and human health; this study investigates its atmospheric concentration variations in Xinjiang, China from 2010-2022 using MERRA-2 data and ground observations.
  • The average annual concentration of atmospheric BC in Xinjiang was 195.40 ng/m, with winter showing the highest levels, and notable spatial variations identified in the northern Tianshan Mountains and around Tarim Basin.
  • Meteorological and environmental factors like snow depth, surface temperature, humidity, NO, PM, and SO were found to strongly influence BC concentration, highlighting critical issues regarding climate change and public health related to BC pollution.
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An unprecedented five-component [2 + 2 + 1 + 1] benzannulation strategy for regioselective assembly of densely functionalized aromatic amines from two ynals, two malononitriles, and sodium sulfinates is established. The benzannulation protocol enables the efficient installation of five substituents on a benzene ring via the formation of multiple chemical bonds in a single operation, providing various multifunctionalized aromatic primary amines in moderate to good yields. Additionally, three-component [3 + 2 + 1] cycloaddition of malononitriles, ynals, and NHSCN was also achieved to produce 2-amnopyridine derivatives with NHSCN serving as an ammonia surrogate.

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  • Site-selective hydrogen atom transfer (HAT) from quinoxaline-2(1)-ones offers a new, efficient method for creating functionalized pyrroloquinoxalinones through synergistic photocatalysis and HAT catalysis.
  • The reaction utilizes bromine radicals to achieve HAT and promotes a cross-coupling process with α-cyano-α,β-unsaturated ketones, streamlining the synthesis.
  • This protocol is advantageous as it avoids transition metals, requires minimal oxidants, and utilizes easily obtainable starting materials, demonstrating significant potential for producing novel imine-containing compounds.
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  • The study evaluates the effectiveness of enterovirus A71 (EV-A71) vaccines in reducing hand, foot, and mouth disease (HFMD) cases among children under 5 in China, with analysis based on surveillance data and statistical models.
  • Findings show that between 2017 and 2018, vaccination led to a significant reduction in HFMD incidence, with a relative risk of 0.83, translating to about 298,000 fewer cases.
  • The effectiveness of the vaccine varied by region, was better in areas with higher vaccination coverage (above 20%), and decreased in more densely populated areas, highlighting the need for improved vaccination strategies.
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Background: Chronic obstructive pulmonary disease (COPD) is one of the primary causes of significant morbidity and mortality worldwide. This study aimed to explore the cross-country inequalities by age, sex, and region in COPD's burden and care quality from 1990 to 2021.

Methods: We obtained data from the Global Burden of Disease 2021.

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Background: Children's lives are increasingly mediated by digital technologies, yet evidence regarding the associations between internet use and depression is far from comprehensive and remains unclear.

Objective: This study aimed to investigate the dose-response association between internet use, including use time and addiction behaviors, and depressive symptoms among children and adolescents in Zhejiang Province.

Methods: Data were collected from a school-based health survey China Common Disease and Risk Factor Surveillance Among Students, encompassing 21,336 students in Zhejiang Province.

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