Publications by authors named "ShuQiao Yao"

Purpose: To systematically investigate the factorial and criterion validity of the Chinese version of the Rosenberg Self-Esteem Scale (RSES) among undergraduate students.

Methods: Altogether 1415 undergraduates completed the RSES, the Short Form of Mood and Anxiety Symptoms Questionnaire, the Perceived Stress Scale and the Quality of Life Enjoyment and Satisfaction Questionnaire. Confirmatory factor analysis was conducted to examine the factorial structure, gender invariance, and latent mean invariance of RSES.

View Article and Find Full Text PDF
Article Synopsis
  • CU traits like shallow emotions and lack of remorse are linked to childhood maltreatment, but the role of brain structures is still unclear.
  • The study investigates the relationship between CU traits, childhood maltreatment, and amygdala volume in adolescents with conduct disorder and healthy controls, finding no major differences in amygdala size but positive correlations with maltreatment and CU traits.
  • It also highlights that gender may significantly affect these relationships, suggesting the need for personalized assessment and intervention strategies for young people displaying CU traits.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to create a predictive model for SSRI effectiveness in treating major depressive disorder (MDD) using cognitive neuropsychological theory and machine learning.
  • Participants included 69 MDD patients and 36 healthy controls, assessed on clinical symptoms, negative biases, and EEG, before and after an 8-week SSRI treatment.
  • Key findings indicated significant differences between MDD patients and controls in social support and cognitive biases, leading to the development of a machine-learning model with 83% accuracy in predicting treatment outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • Sex-specific neurobiological changes contribute to Major Depressive Disorder (MDD), indicating differing effects on brain networks between males and females.
  • Researchers used resting-state fMRI to analyze brain activity in 138 unmedicated MDD patients and 243 healthy controls, revealing significant differences in how these networks operate.
  • The study found male MDD patients exhibited greater activation in certain brain networks compared to healthy males, while female MDD patients showed less persistence in the same networks, suggesting a potential neurobiological marker for sex differences in depression.
View Article and Find Full Text PDF

Background: Distinguishing between trait- and state-like neural alternations in major depressive disorder (MDD) may advance our understanding of this recurring disorder. We aimed to investigate dynamic functional connectivity alternations in unmedicated individuals with current or past MDD using co-activation pattern analyses.

Methods: Resting-state functional magnetic resonance imaging data were acquired from individuals with first-episode current MDD (cMDD, n = 50), remitted MDD (rMDD, n = 44), and healthy controls (HCs, n = 64).

View Article and Find Full Text PDF

Childhood maltreatment (CM) is a common psychological stressor associated with multiple mental disorders. While CM is associated with vulnerability to depression and anxiety, little is known about the specific mechanism underlying this relationship. This study aimed to investigate the white matter (WM) of healthy adults with CM and their relationships with depression and anxiety to provide biological evidence for the development of mental disorders in subjects with childhood trauma.

View Article and Find Full Text PDF

Background: Major depressive disorder (MDD) is a highly prevalent mood disorder affecting more than 300 million people worldwide. Biased processing of negative information and neural hyper-responses to negative events are hallmarks of depression. This study combined cross-sectional and longitudinal experiments to explore both persistent and resolved neural hyper-responses to negative outcomes from risky decision making in patients with current MDD (cMDD) and remitted MDD (rMDD).

View Article and Find Full Text PDF

Microstructural alterations to white matter (WM) have been implicated in the onset and recurrence of major depressive disorder (MDD). The present study aimed to identify trait-like WM abnormality in current and remitted depression, as well as changes to WM that could be specifically related to the state of clinical remission. Diffusion tensor imaging data were collected from 60 patients with medication-naive first episode current depression (cMDD), 41 patients with medication-naive remitted depression (rMDD), and 62 demographically-matched healthy control participants (HCs).

View Article and Find Full Text PDF

Aggression is a core feature of conduct disorder (CD), but the motivation, execution of aggression may vary. A deeper understanding of the neural substrates of aggressive behaviours is critical for effective clinical intervention. Seventy-six Boys with CD (50 with impulsive aggression (I-CD) and 26 with premeditated aggression (P-CD)) and 69 healthy controls (HCs) underwent a structural MRI scan and behavioural assessments.

View Article and Find Full Text PDF
Article Synopsis
  • Despite advancements in neuroimaging research on major depressive disorder (MDD), findings remain inconsistent due to small sample sizes and varying analysis methods, prompting the launch of the Depression Imaging REsearch ConsorTium (DIRECT) and the REST-meta-MDD project, which pooled data from 2,428 functional brain images.
  • The initial analyses revealed significant changes in brain connectivity and dynamics, laying the groundwork for future research and highlighting the need for more comprehensive studies across diverse populations.
  • DIRECT's second phase aims to broaden the investigation of brain alterations in MDD by including various ethnic groups and other mental health disorders, while also focusing on long-term studies of treatment effects and improving neuroimaging methodologies for clinical applications.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the nucleus accumbens (NAc), which is key in reward processing and its role in major depressive disorder (MDD).
  • Through meta- and mega-analysis of resting-state fMRI data, it was found that patients with recurrent MDD exhibited decreased functional connectivity within the NAc-based reward circuits.
  • The research highlights that disrupted connectivity between the reward network and the default mode network (DMN) may aid in differentiating MDD patients from healthy individuals, suggesting potential biomarkers for diagnosis.
View Article and Find Full Text PDF

Purpose: The Childhood Trauma Questionnaire-Short Form (CTQ-SF) is a widely used self-report tool designed to assess juveniles' experiences of abuse and neglect. The current study examined the psychometric properties, particularly measurement invariance of the CTQ-SF in Chinese non-clinical adolescents and adolescents with major depressive disorder (MDD).

Methods: Participants included 1,507 high school students (non-clinical sample) from Hunan Province and 281 adolescent patients with major depressive disorder (MDD sample) from The Second Xiangya Hospital.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to explore decision-making patterns and cognitive characteristics in patients with major depressive disorder (MDD) across different clinical stages, using assessments and the balloon analogue risk task.
  • Findings revealed that while remitted MDD patients showed improvements in certain psychological traits compared to first-episode patients, they still differed significantly from healthy controls, maintaining a conservative decision-making strategy.
  • The study concluded that MDD patients exhibited stable risk-avoidance behaviors regardless of depressive state, with specific neural indicators (like FRN and P3 components) suggesting both state-dependent and state-independent impairments in decision-making processes.
View Article and Find Full Text PDF

Background: Emerging evidence has highlighted the moderating effect of childhood maltreatment (CM) in shaping neurobiological abnormalities in major depressive disorder (MDD). However, whether neural mechanisms underlying stress sensitivity in MDD are affected by the history of CM is unclear.

Methods: Two hundred and thirteen medication-free female participants were recruited for a functional magnetic resonance imaging study assessing the effects of psychosocial stress on neural responses.

View Article and Find Full Text PDF

Major Depressive Disorder (MDD) is characterized by increased stress sensitivity. Emerging findings in healthy adults suggest that stress responses within limbic/striatal-prefrontal regions are moderated by sex and unfold over time. Thus, we hypothesized that stress response abnormalities in MDD might be affected by sex and stress exposure time.

View Article and Find Full Text PDF

Background: Childhood trauma is a major social public-health problem worldwide. Previous literature suggests childhood trauma is associated with the development of psychiatric disorders and maladaptive behaviours later in life, but little is known about the neural basis underlying these associations.

Objective: The aim of the current study was to investigate intrinsic brain network alterations in non-clinical adults with childhood trauma.

View Article and Find Full Text PDF

Herein, we validate the psychometric properties of the Chinese version of the THINC-integrated tool (THINC-it) as a screening tool for cognitive deficits in patients with major depressive disorder. The primary aim of this study is to determine whether cognitive deficits as detected by the THINC-it tool in adults with major depressive disorder (MDD) are associated with workplace productivity and/or psychosocial function. Subjects aged 18-65 ( = 91) with MDD were evaluated and compared to age-, sex- and education- matched healthy controls ( = 95).

View Article and Find Full Text PDF

It has been proposed recently that major depressive disorder (MDD) could represent an adaptation to conserve energy after the perceived loss of an investment in a vital source, such as group identity, personal assets, or relationships. Energy conserving behaviors associated with MDD may form a persistent marker in brain regions and networks involved in cognition and emotion regulation. In this study, we examined whether subcortical regions and volume-based structural covariance networks (SCNs) have state-independent alterations (trait markers).

View Article and Find Full Text PDF

The purpose of this study was to examine the psychometric properties and posited nine-factor structure of the Chinese version of the Cognitive Emotion Regulation Questionnaire (CERQ-C) in high school students and adolescents with major depressive disorder (MDD), including assessment of measurement invariance of CERQ-C and its subscales across gender, time, and presence of depression. Chinese high school students from Hunan Province ( = 1,253) and adolescents with major depressive disorder (MDD) from the Medical Psychological Institute outpatient clinic at The Second Xiangya Hospital ( = 205) were enrolled. We examined the reliability, and model fit of the CERQ-C.

View Article and Find Full Text PDF

There may be distinct conduct disorder (CD) etiologies and neural morphologies in adolescents with high callous unemotional (CU) traits versus low CU traits. Here, we employed surface-based morphometry methods to investigate morphological differences in adolescents diagnosed with CD [42 with high CU traits (CD-HCU) and 40 with low CU traits (CD-LCU)] and healthy controls (HCs, N = 115) in China. Whole-brain analyses revealed significantly increased cortical surface area (SA) in the left inferior temporal cortex and the right precuneus, but decreased SA in the left superior temporal cortex in the CD-LCU group, compared with the HC group.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the alterations in functional homotopy architecture in patients with Major Depressive Disorder (MDD), highlighting a significant reduction in functional connectivity between homotopic brain regions.
  • Using resting-state fMRI data from over 1,000 MDD patients and nearly 900 healthy controls, researchers found specific areas in the brain, like the posterior cingulate gyrus and precuneus, showed notably decreased connectivity in MDDs, with variations related to age and gender.
  • The findings suggest that structural connectivity deficits in MDD may impact how information is exchanged between the brain's hemispheres, correlating with the severity of depressive symptoms and indicating potential areas for further study in treatment.
View Article and Find Full Text PDF
Article Synopsis
  • Patients with major depressive disorder (MDD) show difficulties in decision-making, with neurophysiological mechanisms inadequately understood.
  • A study involving MDD patients and healthy controls revealed that while the groups performed similarly on risk-taking tasks (BART), MDD patients displayed greater stability in risk aversion and larger brain responses to losses (FRN).
  • The research suggests that heightened sensitivity to negative feedback may intensify depressive symptoms, with FRN potentially serving as a marker for this hypersensitivity in MDD.
View Article and Find Full Text PDF

Background: The Center for Epidemiologic Studies Depression scale (CESD) was widely used for screening of depressive symptoms. The purpose of the current study was to investigate the factor structure and measurement invariance of the CESD across genders and groups in a sample of Chinese undergraduates and clinical patients.

Methods: Participants included 3093 undergraduates from the Hunan province and 336 patients from psychological clinics.

View Article and Find Full Text PDF