Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets.

Background: The gut microbiota is a critical factor in the regulation of host health, but the relationship between the differential resistance of hosts to pathogens and the interaction of gut microbes is not yet clear. Herein, we investigated the potential correlation between the gut microbiota of piglets and their disease resistance using single-cell transcriptomics, 16S amplicon sequencing, metagenomics, and untargeted metabolomics.

Results: Porcine epidemic diarrhea virus (PEDV) infection leads to significant changes in the gut microbiota of piglets.

Reversible SAHH inhibitor ameliorates MIA-induced osteoarthritis of rats through suppressing MEK/ERK pathway.

Osteoarthritis (OA) is characterized by gradual articular cartilage degradation, accompanied by persistent low-grade joint inflammation, correlating with radiographic and pain-related progression. The latent therapeutic potential of DZ2002, a reversible inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH), holds promise for OA intervention. This study endeavored to examine the therapeutic efficacy of DZ2002 within the milieu of OA.

Treatment of pregnant mice with ABZ had no effect on the immune response of their offspring infected with Trichinella spiralis.

Trichinellosis is a food-borne parasitic disease with a worldwide distribution that not only endangers human health but also leads to economic loss. Infection of pregnant animals with Trichinella spiralis (T. spiralis) may lead to abortion and other adverse consequences, so it is necessary to treat the infection during pregnancy.

Antiviral effects of Pediococcus acidilactici isolated from Tibetan mushroom and comparative genomic analysis.

Rotavirus is one of the main pathogens that cause diarrhoea in young animals, and countless animals have died of rotavirus infection worldwide. Three strains of lactic acid bacteria isolated from Tibetan mushrooms were used to study the inhibition of rotavirus and . One part was to identify and study the biochemical and probiotic characteristics of three isolated lactic acid bacteria, and the other part was to evaluate the inhibitory effect on rotavirus and experiments.

A phosphorus-doped potassium peroxyniobate electrocatalyst with enriched oxygen vacancies boosts electrocatalytic nitrogen reduction to ammonia.

The electrochemical ammonia synthesis is an environmentally friendly method for ammonia production; however, it is still impeded by the bottleneck of N activation and challenging hydrogen evolution reaction (HER). A rational design for developing efficient electrocatalysts by tuning the surface electronic state is regarded as a promising strategy to overcome these obstacles. Herein, we report a phosphorus-doped potassium peroxyniobate (KNbO, denoted as P-KNO) electrocatalyst with enriched oxygen vacancies to effectively improve N-to-NH efficiency and suppress HER.

Boosting electrochemical nitrogen reduction to ammonia with high efficiency using a LiNbO electrocatalyst in neutral media.

The nitrogen reduction reaction (NRR) has great potential as a method to replace the industrial Haber-Bosch process for ammonia synthesis. Nevertheless, the efficiency of the NRR is mainly dependent on the rational design of highly efficient and active electrocatalysts on account of the high energy of N and HER as a competitive reaction. Herein, a simple solid-phase synthesis method is adopted to design and synthesize a LiNbO (LNO) electrocatalyst, which proves that the synergistic effect of electron-rich Nb and Li elements can effectively improve the NRR activity of commercial NbO and LiCO.

Association between Air Quality and Sedentary Time in 3270 Chinese Adults: Application of a Novel Technology for Posture Determination.

This study investigated the association between ambient air quality and sedentary time in Chinese adults. The participants were 3270 Chinese users (2021 men and 1249 women) of wrist-worn activity trackers. The data of participants' daily activities were collected from July 2015 to October 2015.