Publications by authors named "ShuChang Yao"
The supramolecular chemistry of small chiral molecules has attracted widespread attention owing to their similarity to natural assembly codes. Two-component low-molecular-weight (LMW) hydrogels are crucial as they form helical structures chirality transfer, enabling diverse functions. Herein, we report a pair of two-component chiral LMW hydrogels based on the small molecular drugs baicalin (BA), scutellarin (SCU) and berberine (BBR).
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- * Researchers developed a plant-based antibacterial hydrogel using Kudzu powder and berberine that is highly effective against bacteria, showing excellent adhesion and fast degradation.
- * The hydrogel demonstrates strong antibacterial properties with low toxicity, suggesting its potential for wide clinical use and innovative applications in medicine.
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- Insufficient T cell activation and a complex tumor microenvironment (TME) limit the effectiveness of immunotherapy, presenting challenges for cancer treatment.* -
- A novel hydrogel composed of glycyrrhizic acid, copper ions, and celastrol is developed to enhance TME regulation through chemo-dynamic therapy, promoting cellular apoptosis and anti-tumor effects.* -
- The hydrogel boosts T cell activity and infiltration by polarizing tumor-associated macrophages and enhancing antigen presentation, showing potential when combined with anti-PD-L1 therapy for addressing both primary and metastatic tumors.*
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- Studies show that the arrangement of chiral molecules greatly impacts how they self-assemble, but the effects of epimerization (changes in a single chiral center) had not been previously examined.
- This research focused on two epimers of glycyrrhetinic acid—18 α and 18 β—derived from Glycyrrhiza uralensis, which exhibit different medicinal properties.
- The findings revealed that 18 β-GA can create a nanoparticle structure through a 'head-to-tail' arrangement, while 18 α-GA struggles to assemble due to steric hindrance caused by a 'head-to-head' connection, highlighting how small structural changes can affect molecular behavior and potential applications in medicine.
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- Mahuang Fuzi decoction (MGF), a traditional herbal remedy, is known for treating inflammatory diseases, but its complex phytochemical interactions and effects are still being studied.
- Techniques like dynamic light scattering and electron microscopy were used to analyze the morphology and interactions of MGF and its supermolecule form (MGF SA), finding distinct structural differences when compared to a simple mixture of its components (MIX).
- The study revealed that components in MGF exhibit self-assembly properties, leading to uniform particle formations in MGF SA, which may enhance its clinical effectiveness against inflammation compared to other forms.
We investigate and experimentally demonstrate a fast and robust chromatic dispersion (CD) estimation method based on temporal auto-correlation after digital spectrum superposition. The estimation process is fast, because neither tentative CD scanning based on CD compensation nor specific cost function calculations are used. Meanwhile, the proposed CD estimation method is robust against polarization mode dispersion (PMD), amplified spontaneous emission (ASE) noise and fiber nonlinearity.
View Article and Find Full Text PDFWe propose and demonstrate a novel multi-input multi-output (MIMO) equalization based inter-carrier-interference (ICI) cancellation approach employing constant modulus algorithm (CMA) for supperchanels with sub-Nyquist channel spacing, where optical combs are used as optical sources. Compared with the least mean square (LMS) algorithm based ICI canceller, the proposed approach has comparable capability to accomplish the ICI mitigation for 56 Gbaud dual-polarization quadrature phase shift keying (DP-QPSK) signals with tight channel spacing till 50 GHz. In particular, compared with the LMS-MIMO based ICI canceller, the optical linewidth tolerance of 6 MHz is relaxed to 20 MHz given a 1dB required optical signal-to-noise ratio (OSNR) penalty for the CMA-MIMO based ICI canceller.
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