Publications by authors named "Shu-yu Jin"
Article Synopsis
- A study conducted in Guangzhou, China, found the overall prevalence of heart failure (HF) among community residents aged 35 and over was 1.06%, with men at a higher risk.
- The research indicated that age, atrial fibrillation, valvular heart disease, and chronic conditions like hypertension significantly increased the odds of developing HF.
- HF incidence was notably higher among individuals aged 65 and above, suggesting that managing existing cardiovascular conditions could help lower the risk of HF in this population.
To investigate the anticancer effects of ring C in 18β-glycyrrhetinic acid (GA), a series of GA derivatives featured with 9(11)-ene moiety in ring C were designed and synthesized. The structures were confirmed by IR, LC-MS and 1H NMR. Their inhibitory effects towards human prostate cancer PC-3 and leukemia HL-60 cell lines were determined.
View Article and Find Full Text PDFDesign and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors.
Bioorg Med Chem Lett
February 2016
A novel series of substituted pyrido[3,2-d]-1,2,3-triazines were designed and synthesized as Pim-1 inhibitors through scaffold hopping. Most of the derivatives showed potent in vitro Pim-1 inhibitory activities and anti-proliferative effects toward prostate cancer cells. Among them, 6b, 6h and 6m showed the best Pim-1 inhibitory activity with IC50 values of 0.
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