Publications by authors named "Shu-ying Yi"
The role of vitamin D through SphK1/S1P in the regulation of MS progression.
J Steroid Biochem Mol Biol
February 2024
Sphingosine-1-phosphate (S1P) is biologically active lipid, leading to neuroinflammation and macrophage invasion in central nervous system, plays an important role in the development of multiple sclerosis (MS) model in experimental allergic encephalomyelitis (EAE) rats. Vitamin D is observed to be a key factor in regulating cell S1P levels. We detected vitamin D can alleviate the symptoms of EAE rats, but the exact mechanism is unclear.
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- Acetylshikonin (ASK), derived from the traditional Chinese medicine Lithospermum erythrorhyzon, exhibits properties such as bactericidal, anti-inflammatory, and antitumor effects, but its impact on apoptosis and autophagy in AML cells is not well understood.
- ASK significantly inhibits growth and induces apoptosis in HL-60 cells primarily through the mitochondrial pathway and promotes S-phase cell cycle arrest, while also triggering autophagy as indicated by the formation of autophagosomes.
- The study highlights that ASK-induced autophagy and apoptosis are linked to the activation of the LKB1/AMPK signaling pathway and suppression of the PI3K/Akt/mTOR pathways, as evidenced by changes in specific molecular markers
Selenocysteine (SeC) a natural available selenoamino acid exhibits novel anticancer activities against human cancer cell lines. However, the growth inhibitory effect and mechanism of SeC in human glioma cells remain unclear. The present study reveals that SeC time- and dose-dependently inhibited U251 and U87 human glioma cells growth by induction of S-phase cell cycle arrest, followed by the marked decrease of cyclin A.
View Article and Find Full Text PDFThe COX-2 inhibitors Rofecoxib (Rof) and Lumiracoxib (Lum) were evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). Administration of Rof and Lum significantly reduced the incidence and severity of EAE, which was associated with the inhibition of MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell responses, and modulation of cytokines production. In vitro Rof and Lum inhibited primary T cells proliferation and modulated cytokine production.
View Article and Find Full Text PDFSmall heat shock proteins (sHSPs) are the major family of HSP induced by heat stress in plants. In this report, an approximately 1.9kb of Lehsp23.
View Article and Find Full Text PDFThe chloroplast HSP100/ClpB is a newly documented member of the ClpB family, but little was known about its role in imparting thermotolerance to cells. A cDNA coding for a HSP100/ClpB homolog has been cloned from Lycopersicon esculentum and termed as Lehsp100/ClpB (the cDNA sequence of Lehsp100/ClpB has been submitted to the GenBank database under accession number: AB219939). The protein encoded by the cDNA was most similar to the putative chloroplast HSP100/ClpBs in higher plants and the ClpB from Cyanobacterium Synechococcus sp.
View Article and Find Full Text PDF[Molecular cloning of tomato LeHsp110/ClpB gene and its effect on the thermotolerance in plant].
Sheng Wu Gong Cheng Xue Bao
January 2006
Article Synopsis
- ClpB is a heat shock protein that functions as a molecular chaperone and is linked to thermotolerance in organisms.
- A tomato cDNA was isolated, revealing a polypeptide with 980 amino acids classified as LeHSP110/ClpB, which is heat-inducible but not expressed at normal temperatures.
- Transgenic tomato plants with reduced levels of LeHSP110/ClpB showed increased sensitivity to high temperatures, indicating its crucial role in plant thermotolerance.
Cloning and molecular characteristic of the metalloprotease gene LeftsH6 from tomato.
Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao
February 2006
Article Synopsis
- A full-length 2213-bp ftsH cDNA was isolated from heat-shocked tomato leaves, identifying a protein precursor likely targeted to chloroplasts.
- The ftsH-like protein, named Lycopersicon esculentum filamentation temperature-sensitive H6 (LeftsH6), contains characteristic domains similar to the FtsH6 from Arabidopsis.
- Functional assays showed that purified FtsH can degrade casein but loses activity with a specific mutation, with gene expression confirmed to be heat-inducible and absent under other stress conditions, marking it as the first evidence of a heat-inducible ftsH gene in higher plants.