Publications by authors named "Shu-ying Li"

Abnormal differentiation of cells is a hallmark of malignancy. Induction of cancer-cell differentiation is emerging as a novel therapeutic strategy with low toxicity in hematological malignances, but whether such treatment can be used in solid tumors is not known. Here, we uncovered a novel function of acetyl coenzyme A acetyltransferase (ACAT1) in regulating the differentiation of glioblastoma (GBM) cells.

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  • The study focuses on assessing the nutritional status of elderly patients with prostate cancer and its impact on their prognosis, identifying malnutrition in differing percentages using three scoring systems: NRI, PNI, and CONUT.
  • It employs various analytical methods to compare survival rates and validate the effectiveness of these scoring systems against the traditional AJCC staging.
  • Findings indicate that NRI and PNI are reliable indicators of progression-free survival, suggesting early nutritional interventions could enhance patient outcomes.
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  • A fatal case of primary amoebic meningoencephalitis was linked to an indoor surfing center in Taiwan, identified through monitoring for encephalitis symptoms.
  • Environmental testing revealed that 1 out of 56 specimens contained the Naegleria fowleri amoeba.
  • The report highlights the dangers of N. fowleri infections from poorly disinfected recreational water, including indoor facilities.
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Neuroinflammation plays important roles in retinal ganglion cell (RGC) degeneration in glaucoma. MicroRNA-146 (miR-146) has been shown to regulate inflammatory response in neurodegenerative diseases. In this study, whether and how miR-146 could affect RGC injury in chronic ocular hypertension (COH) experimental glaucoma were investigated.

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The aim of this study was to explore the neuroprotective effects of the P2X7 receptor antagonist A740003 on retinal ganglion cells (RGCs) in chronic intraocular hypertension (COH) experimental glaucoma mouse model. Bioinformatics was used to analyze the glaucoma-related genes. Western blot, real-time fluorescence quantitative PCR, and immunofluorescence staining techniques were employed to explore the mechanisms underlying the neuroprotective effects of A740003 on RGCs in COH retinas.

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  • Salmonella is a major foodborne pathogen that threatens food safety and public health, with growing concerns over antibiotic misuse leading to drug residues in food products.
  • * The study identifies two new virulent bacteriophages, sp11241 and 8-19, that effectively target Salmonella enterica serotype Enteritidis, showing potential as eco-friendly solutions to control this pathogen in food.
  • * When tested on whole chicken eggs, raw chicken meat, and lettuce at various concentrations, the phages significantly reduced Salmonella levels, demonstrating their effectiveness at low temperatures and highlighting their potential for food safety applications.
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Objective To investigate the relationship between cerebrovascular reactivity (CVR) and emotional disorders in the patients undergoing continuous hemodialysis for end-stage renal disease (ESRD).Methods The clinical data of the ESRD patients undergoing continuous hemodialysis were collected.Anxiety and depression of the patients were assessed by the Hamilton anxiety scale (HAMA) and Beck depression inventory,respectively.

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  • As people live longer, women are also having children at an older age, which affects their ovaries.
  • Ovaries show signs of aging, like a decrease in egg quality and quantity, from the time a girl is born.
  • New studies are exploring how gut bacteria can impact ovarian health and how we can use things like probiotics to help slow down ovarian aging.
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2D compounds exfoliated from weakly bonded bulk materials with van der Waals (vdW) interaction are easily accessible. However, the strong internal ionic/covalent bonding of most inorganic crystal frameworks greatly hinders 2D material exfoliation. Herein, we first proposed a radical/strain-synergistic strategy to exfoliate non-vdW interacting pseudo-layered phosphate framework.

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  • Interlayer intercalation engineering enhances the stability of layered oxides, specifically in improving Zn-storage capacity with the use of multiple intercalated metal ions.
  • This study investigates the inclusion of alkali (K), alkaline earth (Mg), and trivalent (Al) metal ions in the VO interlayer of vanadium oxides (VO) to optimize interlayer spacing and structure.
  • The resulting tri-metal ion intercalated hydrated VO cathode demonstrates a high specific capacity of 382.4 mAh/g and excellent cycling stability, retaining 86% capacity after 2000 cycles, suggesting a promising approach for designing better materials for zinc-ion batteries.
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The unique electronic and crystal structures of rare earth metals (RE) offer promising opportunities for enhancing the hydrogen evolution reaction (HER) properties of materials. In this work, a series of RE (Sm, Nd, Pr and Ho)-doped Rh@NSPC (NSPC stands for N, S co-doped porous carbon nanosheets) with sizes less than 2 nm are prepared, utilizing a simple, rapid and solvent-free joule-heat pyrolysis method for the first time. The optimized Sm-Rh@NSPC achieves HER performance.

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NaMnTi(PO) (NMTP) emerges as a promising cathode material with high-performance for sodium-ion batteries (SIBs). Nevertheless, its development has been limited by several challenges, including poor electronic conductivity, the Mn Jahn-Teller effect, and the presence of a Na/Mn cation mixture. To address these issues, we have developed a cation/anion-dual regulation strategy to activate the redox reactions involving manganese, thereby significantly enhancing the performance of NMTP.

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Formononetin (FNT) is a plant-derived isoflavone natural product with anti-inflammatory, antioxidant, and anti-allergic properties. We showed previously that FNT inhibits immunoglobulin E (IgE)-dependent mast cell (MC) activation, but the effect of FNT on IgE-independent MC activation is yet unknown. Our aim was to investigate the effects and possible mechanisms of action of FNT on IgE-independent MC activation and pseudoallergic inflammation.

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Extraordinary excitability (hyperexcitability) is closely related to retinal ganglion cell (RGC) injury in glaucoma. Dopamine (DA) and its receptors are involved in modulating RGC excitability. We investigated how DA system affects RGC injury in chronic ocular hypertension (COH) experimental glaucoma model.

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Porous organic polymers are considered as excellent candidates for the electrode materials in rechargeable battery due to their desirable properties including porosity, customizable structure, and intrinsic chemical stability. Herein a Salen-based porous aromatic framework (Zn/Salen-PAF) is synthesized through a metal directed method and further used as efficient anode materialfor lithium-ion battery. Attributing to the stable functional skeleton, Zn/Salen-PAF delivers a reversible capacity of 631 mAh·g at 50 mA·g, a high-rate capability of 157 mAh·g at 20.

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To assess the inter-relationships between residual depressive symptoms (RDS) and Internet addiction (IA) using network analysis among clinically stable adolescents with major psychiatric disorders during the COVID-19 pandemic. RDS and IA were assessed using the Patient Health Questionnaire-9 (PHQ-9) and the Internet Addiction Test (IAT), respectively. Central symptoms and bridge symptoms in the network model were examined.

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A Gram-negative, aerobic, rod-shaped, motile bacterium with multi-flagella, strain RS, was isolated from bacterial wilt of tobacco in Yuxi city of Yunnan province, China. The strain contains the major fatty acids of C, summed feature 3 (C 7 and/or C 6), and summed feature 8 (C 7 and/or C 6). The polar lipid profile of strain RS consists of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, and unidentified aminophospholipid.

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  • The study investigates how endophytic bacteria, specifically two strains of Priestia megaterium isolated from potato and dendrobium, interact with their host plants and their secondary metabolites.
  • P. megaterium P-NA14 showed stronger inhibition against dendrobium pathogens, while P. megaterium D-HT207 was more effective against potato pathogens, with each strain selectively targeting different bacteria (Staphylococcus aureus and Escherichia coli respectively).
  • The metabolomic analysis revealed that P. megaterium P-NA14 had higher levels of L-phenylalanine, suggesting that the differences in antimicrobial activities between the two strains could be linked to the presence of specific metabolites derived from this amino acid
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Understanding the origin of homochirality in macroscopic assemblies and manipulating organizational chirality still remain a challenge. Herein, homochirality is achieved by combination of the majority-rules principle and concentration-dependent molecular assembly at the liquid/solid interface. A lower molecular concentration in solution facilitates more efficient amplification of chirality, which is formulated by a cooperative equilibrium model based on the Langmuir adsorption isotherm.

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The phytochemical investigation of the EtOAc extract from the aerial parts of Isodon eriocalyx afforded seventeen diterpenoids, including eight undescribed compounds. Eriocalyxins H-L have unique structural characteristics featuring a 5-epi-ent-kaurane diterpenoid scaffold with eriocalyxins H-K also possess an unusual 6,11-epoxyspiro-lactone ring while eriocalyxin L, a 1,7:3,20-diepoxy-ent kaurene, features an 1,7-oxygen linkage. The structures of these compounds were elucidated by spectroscopic data interpretation, and the absolute configurations of eriocalyxins H, I, L, and M were confirmed by single-crystal X-ray diffraction.

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Objective: This study examined the prevalence of cyberbullying and its relationship with residual depressive symptoms in this patient population during the COVID-19 outbreak using network analysis.

Methods: This was a multicenter, cross-sectional study. Adolescent patients attending maintenance treatment at outpatient departments of three major psychiatric hospitals were included.

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Previous work showed that ephrinA3/EphA4 forward signaling contributed to retinal ganglion cell (RGC) damage in experimental glaucoma. Since up-regulated patterns of ephrinA3 and EphA4 were observed in Müller cells and RGCs, an EphA4/ephrinA3 reverse signaling may exist in Müller cells of chronic ocular hypertension (COH) retina. We investigated effects of EphA4/ephrinA3 reverse signaling activation on Müller cells in COH retina.

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Background: Erectile dysfunction (ED) mainly affects men over 40 years of age and is a common clinical condition. In addition to hypertension and diabetes, environment, and lifestyle are also significantly associated with erectile dysfunction. The relationship between dietary trace metal intake and ED has not been studied.

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  • From April to November 2021, Taiwan experienced a significant wave of COVID-19 infections from the Alpha variant, leading to 14,458 cases and 830 deaths among over 3.8 million tested.
  • To manage this surge, by December 2021, Taiwan established a network of 249 laboratories capable of conducting 158,492 tests daily across 22 regions, with over 9.5 million specimens tested by April 2022.
  • Various testing methods, including automated high-throughput, rapid antigen testing, and saliva testing, were deployed to enhance diagnostic capacity, while challenges like resource limitations and laboratory system integration were addressed.
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