Publications by authors named "Shu-xiao Bai"
[Clinical Significance of Common Gene Mutations in 53 Patients with Acute Myeloid Leukemia Harboring 11q23/MLL Rearrangements].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2020
Article Synopsis
- The study focused on acute myeloid leukemia (AML) patients with 11q23/MLL rearrangements to assess the implications of these mutations on their health outcomes.
- A total of 53 cases were analyzed, revealing that 43.4% had gene mutations, with N-RAS and WT1 being the most common.
- Results indicated that while patients with gene mutations had a median overall survival (OS) of 8.5 months, those without mutations had a better OS of 13 months; patients receiving hematopoietic stem cell transplantation (HSCT) had a significantly improved median OS of 22.5 months.
- The findings suggest the presence of mutations in these patients does not alleviate poor prognosis,
[Clinical and cytogenetic study of 6 cases of hematological disorders associated with 20q- and t (20;21) (q11;q11) abnormalities].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
April 2013
Objective: To analyze clinical and cytogenetic features of hematological disorders associated with 20q- and t (20;21) (q11;q11) abnormalities.
Methods: Following short-term culture of bone marrow cells, karyotypic analysis was carried out with R-banding. 20q- and t(20;21) (q11;q11) was detected by fluorescence in situ hybridization (FISH) using dual-color 20q11/12 probe, ST 20qter /ST 21qter probes, SE20(D20Z1)/SE 13/21 probes, and WC20/WC21 probes.
[Clinical and experimental study of a multiple myeloma case with low hypodiploidy].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2012
Objective: To report the clinical and laboratory characterization of a case of multiple myeloma with low hypodiploid complex karyotyptic abnormalities.
Methods: Cytogenetic examination of bone marrow performed by 24 h culture method. R-banding technique was used to analyze the karyotype.
[Fluorescence in situ hybridization study of acute myeloid leukemia with cryptic chromosome rearrangements].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
December 2011
Objective: To detect specific chromosome rearrangements in acute myeloid leukemia (AML) using interphase-fluorescence in situ hybridization (FISH).
Methods: All cases were studied by R-band karyotypic analysis using direct method and/or short-term culture for chromosomes preparation. Interphase-FISH was performed in 108 cases of AML with M5, M4, M2, M3 subtypes including 103 cases with normal karyotypes, 4 cases with chromosomal abnormalities other than specific chromosomal rearrangements using chromosome translocation probe such as AML1/ETO, PML/RARα, CBFβ/MYH11 and MLL.
[Fluorescence in situ hybridization studies on a myeloid leukemia patient with ins(8;21)(q22;q22.1q22.3)].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
April 2009
Objective: To report a case of acute myeloid leukemia (AML) with the insertion (8;21)(q22;q22.1q22.3).
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