Publications by authors named "Shu-wen Jin"
Electroacupuncture (EA) is an effective alternative for the treatment of functional dyspepsia (FD). It reduces low-grade duodenal inflammation and improves the symptoms of FD by downregulating the expression of NF-κB p65 and NLRP3, but its mechanism needs to be elucidated. To examine the regulatory effect of electroacupuncture (EA) on intestinal flora and NF-κB p65/NLRP3 pyroptosis pathway in FD rats.
View Article and Find Full Text PDFAims: Intestinal barrier dysfunction is the initial and propagable factor of sepsis in which acute kidney injury (AKI) has been considered as a common life-threatening complication. Our recent study identifies the regulatory role of Pellino1 in tubular death under inflammatory conditions in vitro. The objective of our current study is to explore the impact of Pellino1 on gut-kidney axis during septic AKI and uncover the molecular mechanism (s) underlying this process.
View Article and Find Full Text PDFThis experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats. Liver and adipose tissues were assessed histologically, and body and liver weight, serum and liver lipid levels, expression of mTOR/ubiquitin-specific peptidase 20 (USP20)/recombinant 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), and phosphorylation of mTOR and USP20 were measured. deubiquitination assays with liver cytosol were conducted.
View Article and Find Full Text PDF[Study of neovascularization disturbance in deep partial-thickness scald in rats with diabetes mellitus].
Zhonghua Shao Shang Za Zhi
February 2008
Article Synopsis
- The study investigates how neovascularization (the formation of new blood vessels) relates to non-healing wounds in diabetic rats after they experience scald injuries.
- Two groups of rats were used: a control group treated with saline and a diabetic group treated with streptozocin, then both groups were given scald injuries.
- Results showed that diabetic rats had significantly slower wound healing rates and lower levels of neovascularization compared to controls, despite having a similar number of vascular endothelial cells that failed to form functional capillaries.
[Effects of advanced glycosylation end products on the biological behavior of neutrophils].
Zhonghua Shao Shang Za Zhi
February 2008
Objective: To investigate the effects of advanced glycation end products (AGE) on the biological behavior of neutrophils in vitro, to look for the relationship between accumulation of AGE and abnormal inflammation in wound healing in diabetic mellitus patients.
Methods: Neutrophils were isolated from SD rats and incubated in vitro. The cells were divided into four groups according to different concentrations of AGE in cell suspension: control group (C, with treatment of RPMI - 1640), A group (with treatment of 0.
[Study on the mechanism of scar formation: epidermis template defect theory].
Zhonghua Shao Shang Za Zhi
February 2007
Article Synopsis
- The degree of skin damage impacts how well wounds heal, and significant damage can lead to excessive scarring.
- The dermis's three-dimensional structure acts as a guide for cell growth and affects how cells behave during the healing process.
- Maintaining the integrity of the dermal tissue is essential for proper healing; damage to this structure can lead to abnormal tissue repair and scar formation.
Objective: To study the effect of the cutaneous and blood contents of glucose on wound healing in diabetic rats with superficial partial thickness scalding.
Methods: 96 Sprague-Dawley rats were randomized into control group and STZ-induced diabetic group, inflicted with superficial partial thickness scalding of 10% TBSA on the back. The glucose content in the blood and wound tissue were evaluated before injury and at day 1, day 3, day 5, day 7, day 10 and day 14 after injury.
[Influence of L-arginine supplementation on the plasma amino acid spectrum in burn patients].
Zhonghua Shao Shang Za Zhi
August 2005
Article Synopsis
- - The study tested how L-arginine supplementation affects amino acid levels in burn patients by comparing two groups: one receiving L-arginine and the other a standard amino acid mix.
- - Blood samples were taken at various intervals post-burn, revealing that L-arginine levels in the experimental group were consistently higher than in the control group, especially by days 14, 21, and 28 post-burn.
- - The research concluded that L-arginine supplementation significantly improved plasma levels of specific amino acids (ornithine and citrulline) in burn patients compared to the control group, indicating its potential benefits in recovery.
Article Synopsis
- The study examined how performing tangential excision on burn wounds within the first 24 hours affects inflammation and tissue damage in patients with deep partial thickness burns.
- Twelve patients provided tissue samples from areas before and after the procedure, as well as from areas that did not receive treatment.
- Results showed that excision significantly reduced inflammatory markers and necrosis in treated wounds compared to untreated areas, suggesting it may enhance healing.
Article Synopsis
- A study was conducted to create a rabbit ear model for observing hypertrophic scar formation, using 60 ears from 32 New Zealand white rabbits with full skin defects.
- The healing process was monitored over 12 months after applying silver sulfadiazine cream, with control ears left untreated for comparison.
- Results showed that scar characteristics evolved through overgrowth, maturation, and degeneration, making this model suitable for understanding hypertrophic scars and assessing treatment methods.
[An experimental study on the effects of postburn dietary supplementation of enhanced nutrients].
Zhonghua Shao Shang Za Zhi
August 2003
Objective: To evaluate the effects of postburn dietary supplementation of arginine (Arg), omega-3 polyunsaturated fatty acid (omega-3PUFA) and glutamine (Glu) on the metabolism, immunology and wound healing in scalded rats.
Methods: Thirty Sprague-Dawley (SD) rats inflicted with 30% total body surface area deep partial thickness scald on the back after the gastrostomy catheter was placed were employed as the model. The rats were randomly divided into A and B groups, and all of them received continuous isonitrogenous (25% protein, 12% fat, 63% carbohydrate), isocaloric (175 kcal/kg/day), and isovolemic intragastric tube feedings.