[Effect of coriaria lactone on the activation of Ca(2+)-activated K+ channel in hippocampal pyrimidal neurons of rats].

Objective: This research sought to disclose the regulatory effect of Coriaria lactone (CL) on the Ca(2+)-activated K+ channel in hippocampal pyrimidal neurons of Wistar rats in epileptogenesis.

Methods: Cell-attached and inside-out methods of patch clamp technique were used to record the activity of single channel. The sample data were stored in a computer and analyzed by the application of Pclamp softwares.