Hot melt extrusion technology for improved dissolution, solubility and "spring-parachute" processes of amorphous self-micellizing solid dispersions containing BCS II drugs indomethacin and fenofibrate: Profiles and mechanisms.

Many strategies have been employed to improve oral drug delivery. One such approach involves the use of supersaturable delivery systems such as amorphous self-micellizing solid dispersions (SmSDs). SmSDs have attracted more attention recently, but little is known regarding the impact of production methods on profiles and internal mechanisms of final SmSDs in spite of its importance.

[Human skin infestation caused by : a case report].

Our study reports a case of acarodermatitis caused by . By morphological observations, the mites seized were identified as (deutonymph) which could attack humans resulting in acarodermatitis characterized with the symptoms of papules and blisters in different degrees. The patient was treated with 15% calamine lotion and anti-inflammatory and antipruritic drugs.

Untargeted metabolomics approach (UPLC-Q-TOF-MS) explores the biomarkers of serum and urine in overweight/obese young men.

Background And Objectives: Obesity is linked to metabolic diseases characterized by insulin resistance, such as diabetes and cardiovascular disease. In this study, we investigated the metabolic disorders of uncomplicated obesity to identify early alterations in biological systems.

Methods And Study Design: Metabolic differences between overweight/obese (n=36) and normal-weight (n=35) young Chinese men without known metabolic disorders were assessed.

Visual field impairment predicts recurrent stroke after acute posterior circulation stroke and transient ischemic attack.

Aims: To evaluate whether visual field impairment (VFI) can predict stroke recurrence in patients with vertebral-basilar (VB) stroke.

Methods: A total of 326 patients were eligible for a VFI evaluation within 1 week of stroke onset. One-year follow-up data were obtained after VB stroke and other vascular events.

Oxidative damage of mitochondrial respiratory chain in different organs of a rat model of diet-induced obesity.

Purpose: Mitochondrial dysfunction plays an important role in the development of obesity and obesity-associated metabolic diseases.

Methods: In this study, we dynamically observed the characteristics of mitochondrial damage in a rat model of diet-induced obesity (DIO). From the 2nd to the 10th week, animals were killed every 2 weeks and the heart, liver, kidney, and testicular tissues were harvested.

Novel CYP4V2 mutations associated with Bietti crystalline corneoretinal dystrophy in Chinese patients.

Aim: To analyze the CYP4V2 mutations in five unrelated Chinese patients with Bietti crystalline corneoretinal dystrophy (BCD) and to provide clinical features of these patients. BCD is a rare monogenic autosomal recessively inherited disorder characterized by the presence of crystals in the retina and retinal pigment epithelium atrophy. Mutations in the CYP4V2 gene have been found to be causative for BCD.

Effects of gastrointestinal motility on obesity.

Background: Changes of gastrointestinal motility, which are important related to the food digestion and absorption in the gastrointestinal tract, may be one of the factors in obesity-formation.

Aims: The changes of gastrointestinal motility were explored in the rats from diet-induced obesity (DIO), diet-induced obese resistant (DR) or control (CON) by diet intervention.

Methods: After fed with a high fat diet (HFD), 100 male Sprague-Dawley rats were divided into DIO, DR and CON groups.

[Current status and progress of fungal endophthalmitis treatment].

Fungal endophthalmitis is a devastating infectious disease, with a poor visual prognosis and even possibility of eyeball enucleated. In recent years, the incidence of fungal endophthalmitis remarkably increased due to widely use of broad-spectrum antibiotics and corticosteroid hormone. This pose a challenge to ophthalmologists and their capacity of treating fungal endophthalmitis need to be improved.

[Vitreal surgery and etiological diagnosis of bacterial endophthalmitis].

Objective: To evaluate the clinical effects of vitreal surgery and the importance of etiological diagnosis in the treatment for bacterial endophthalmitis.

Methods: Retrospective series case study. 20 cases (20 eyes) of bacterial endophthalmitis that were treated in Peking Union Hospital were enrolled.

[Ocular toxicity associated with drugs].

The clinical manifestation of ocular toxicity associated with drugs are various. The ocular toxic manifestations and the degree of impairment are different due to the variety, dose, and routes of exposure and so on. It is difficult to diagnose the cause of the toxicity.

Meta-analysis of the relationship between obestatin and ghrelin levels and the ghrelin/obestatin ratio with respect to obesity.

Introduction: The association between gastrointestinal hormones, obestatin and ghrelin, and obesity are controversial. Here, the authors summarize results of published works in this field by using meta-analysis.

Methods: Studies that evaluated these hormones and were published before December 2009 were collected from PubMed, HighWire Press and ProQuest Health and Medical Complete.

[Diagnosis and treatment of eye diseases associated with HIV infection and AIDS].

Objective: To investigate the manifestations and treatment principles of ocular diseases associated with human immunodeficiency virus infection (HIV) and acquired immunodeficiency syndrome (AIDS).

Methods: It was a retrospective case series. One hundred and ten patients were recruited.

Alpha1-macroglobulin: a potential obesity-related factor in serum.

Background: The identification of factors related to obesity is very important for an early diagnosis of susceptibility to obesity and, accordingly, its prevention. The objective of the current study was to search for specific obesity-related factors in serum, as they can be measured non-invasively.

Material/methods: Male Sprague-Dawley rats were fed a high-fat (HF) diet for eight weeks to generate obesity-prone (OP) and obesity-resistant (OR) rats.

Post-weaning isocaloric hyper-soybean oil versus a hyper-carbohydrate diet reduces obesity in adult rats induced by a high-fat diet.

The aim of this study was to investigate the effects of a post-weaning isocaloric hyper-soybean oil diet on later obesity and explore the underlying mechanisms. In the present study, newborn male Wistar rats were weaned on d 24, divided into CON (control), HC and HSO groups. CON was assigned to AIN-93G diet (a hypercarbohydrate diet, for short HC diet) during the entire experiment.

[Effects of chromium and fish oil on the level of leptin and insulin in obese rats].

Objective: In order to study the effects of chromium and fish oil on the level of leptin and insulin in obese rats, 32 obese model rats were divided randomly into four groups: fish oil group (5 ml/kg bw), chromium group (3 mg/kg bw), fish oil + chromium group and high fat diet group.

Methods: In the end of the experiment (6 weeks) fats around kidney and spermary were weighted and blood samples were collected to determine the level leptin and insulin.

Results: The results showed that the level of leptin and insulin in experimental groups were lower than those in high fat diet group.

[Effects of different diet composition after weaning on the obesity in rats induced by high-energy diet].

Objective: To explore the effects of different diet composition on the obesity in rats induced by high-fat diet after weaning.

Methods: Male Wistar rats weaned on 24 days were randomly divided into groups A, B and C and were assigned to high carbohydrate, i.e.

[Expression of hormone-sensitive lipase mRNA in diet-induced obesity resistant rats].

Objective: In order to explore the expression of hormone-sensitive lipase (HSL) mRNA in white adipose tissue of diet-induced obesity-resistant (DIO-R) rats.

Methods: Fifty male Sprague-dawley (SD) rats were randomly divided into control group and high-fat group and they were fed with basic diet and high-fat diet respectively for 13 weeks. DIO-R and DIO rats were selected according to their body weight and the quantity of energy intake, then observing changing of the body fat content, the level of serum growth hormone was determined by radioimmunoassay and the level of the HSL mRNA in white adipose tissue was determined by RT-PCR.

[Expression of uncoupling protein-2 mRNA in diet-induced obesity-resistant rats].

Objective: To explore the expression of uncoupling protein-2 mRNA in brown adipose tissue, white adipose tissue and skeletal muscle of diet-induced obesity-resistant (DIO-R) rats.

Methods: Fifty male Sprague-Dawley (SD) rats were randomly divided into a control group and a high-fat group and fed with basic diet and high-fat diet respectively for 13 weeks. DIO-R and DIO rats were selected according to their body weight.