Effects of Polymorphisms in Pre-miRNA on Inflammatory Markers in Atrial Fibrillation in Han Chinese.

Background: MicroRNA molecules have been identified to play key roles in a broad range of physiological and pathological processes. Polymorphisms in the corresponding sequence space are likely to make a significant con-tribution to phenotypic variation. The aim of this study was to evaluate the pre-miR-146a C/G (rs2910164) and pre-miR-499 T/C (rs3746444) polymorphisms and their putative association with inflammatory markers in AF in Han Chinese.

Molecularly imprinted polymer prepared with polyhedral oligomeric silsesquioxane through reversible addition-fragmentation chain transfer polymerization.

Polyhedral oligomeric silsesquioxane (POSS) was utilized to prepare imprinted polymer through reversible addition-fragmentation chain transfer polymerization (RAFT) successfully. The imprinted polymer was made with a mixture of RAFT agent, 4-vinylpyridine (4-VP), POSS monomer [PSS-(1-propylmethacrylate)-heptaisobutyl substituted, MA 0702], and ethylene glycol dimethacrylate (EDMA), with ketoprofen (KET) as template. The influence of polymerization variables, the amount of RAFT agent and POSS monomer, the ratio of KET to 4-VP, and the ratio of 4-VP to EDMA, were investigated on the retention factor and imprinting effect.

The Relationship between Interleukin-6 Promotor Polymorphisms and Slow Coronary Flow Phenomenon.

Background: Several lines of evidence suggest that slow coronary flow (SCF) phenomenon seems to be an early form of atherosclerosis and low-grade inflammation plays a role in the development of SCF. Interleukin-6 (IL-6) is a pleiotropic cytokine, functions as a mediator of inflammatory response, and has both pro-inflammatory and anti-inflammatory properties. The aim of the present study is to investigate the relationship between IL-6 -634C/G polymorphism and SCF in Han Chinese.

Green synthesis of polymer monoliths incorporated with carbon nanotubes in room temperature ionic liquid and deep eutectic solvents.

In this work, an efficient method to prepare polymer monoliths with incorporated carbon nanotubes in a mixture of room temperature ionic liquid and deep eutectic solvents was developed. With assistance of the binary green solvent, 1-butyl-3-methylimidazolium tetrafluoroborate and choline chloride/ethylene glycol, single-walled carbon nanotubes were dispersed successfully in pre-polymerization mixture without need of oxidative cutting of carbon nanotubes, which may allow depletion of the emission of volatile organic compounds into environment. The novel single-walled carbon nanotubes monolith was evaluated by capillary electrochromatography.

Interleukin-6 genotypes and serum levels in Chinese Hui population.

Interleukin-6 (IL-6) is a key pro-inflammatory cytokine involved in different physiologic and pathophysiologic processes, and circulating levels of IL-6 differ greatly between individuals. The Chinese Hui is one of the largest ethnic minorities, little is known about the distribution of IL-6 genetic variations and their effects on serum levels in Hui population. The aim of the present study is to determine the prevalence of -174G/C (rs1800795), -597G/A (rs1800797), and -634C/G (rs1800796) polymorphisms in the IL-6 gene promoter region and their association with IL-6 serum levels in the Ningxia Hui population.

Interleukin-6 promoter polymorphisms and susceptibility to atrial fibrillation in elderly Han Chinese patients with essential hypertension.

There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF). Interleukin-6 (IL-6) is a pleiotropic cytokine, functions as a mediator of inflammatory response, and has both proinflammatory and anti-inflammatory properties. The aim of the present study was to investigate the association of the -634C/G polymorphism of the IL-6 gene with AF in elderly Han Chinese patients with essential hypertension (EH).

The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population.

Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China).

The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese.

Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH patients and 194 healthy controls from Jiangsu area (south of China).

Interleukin-6 -634C>G polymorphism in hypertensive patients with and without left ventricular hypertrophy.

There is an accumulating body of evidence indicating that inflammation plays a pivotal role in the pathogenesis of cardiovascular disease. Interleukin-6 (IL-6) is a pleiotropic cytokine secreted by many cells of the immune system, cardiovascular components and adipose tissue, and functions as a mediator of inflammatory response with both pro- and anti-inflammatory properties. Circulating levels of IL-6 differ greatly between individuals due to both genetic and environmental factors.

Interleukin 6 promoter polymorphisms in normal Han Chinese population: frequencies and effects on inflammatory markers.

Background: Interleukin 6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes, and circulating levels of IL-6 differ greatly between individuals, but the results have not always been concordant among diverse populations. The aim of present study was to determine the prevalence of the 3 polymorphisms (-174G/C, -597G/A, and -634C/G) in the IL-6 gene promoter region and their effects on inflammatory markers in normal Han Chinese population.

Methods: A total of 232 subjects (143 men and 89 women; mean age, 51.

[A new type of spotted fever group Rickttsiaes detected in the area of Changbai mountain, Jilin province].

Objective: In order to find out the current situation of tick-borne spotted fever in the area of Changbai mountain, Jilin province.

Methods: In this study, a polymerase chain reaction (PCR) method was developed with primers R. rOmpA 190.