Anterior Segment Characteristics and Risk Factors for Primary Angle Closure Disease With Long Axial Lengths: The Handan Eye Study.

Purpose: To investigate the anterior segment characteristics of primary angle closure disease (PACD) with long axial length (AL) compared with that of those with short and medium AL and explore the risk factors associated with AC with different AL levels.

Methods: This observational cross-sectional study enrolled subjects aged 35 years or older who completed the follow-up examinations of the Handan Eye Study and dichotomized them into normal and PACD groups. Ocular data of the right eye were analyzed.

Predictors of angle widening after laser iridotomy in Chinese patients with primary angle-closure suspect using ultrasound biomicroscopy.

Aim: To assess the predictive value of baseline parameters of ultrasound biomicroscopy (UBM) for angle widening after prophylactic laser peripheral iridotomy (LPI) in patients with primary angle-closure suspect (PACS).

Methods: Angle-opening distance (AOD), trabecular iris angle (TIA), iris thickness, trabecular-ciliary process angle, and trabecular-ciliary process distance were measured using UBM performed before and two weeks after LPI. Iris convexity (IC), iris insertion, angulation, and ciliary body (CB) size and position were graded.

Longitudinal observation of intraocular pressure variations with acute altitude changes.

Background: Higher intraocular pressure (IOP) is a major risk factor for developing glaucoma, and the leading cause of irreversible blindness worldwide. High altitude (HA) may be involved in IOP, but the reported results were conflicting. Ascent to HA directly by plane from low altitude regions is an acute, effortless exposure.

Intervention of laser periphery iridectomy to posterior iris bowing in high myopic eyes.

Background: For some high myopic patients with posterior iris bowing, laser periphery iridectomy should be performed pre-operation to prevent pupil block glaucoma if these patients would have phakic intraocular lens implantation to correct high myopia. So we had the opportunity to analysis the influence of laser iridectomy on posterior iris bowing.

Methods: Eighteen high myopic patients with posterior iris bowing (11 males and 7 females) were involved in the study in Beijing Tongren Eye Center from March 2008 to July 2008.

Comparative study of optic disc measurement by Copernicus optical coherence tomography and Heidelberg retinal tomography.

Background: Copernicus optical coherence tomography (SOCT) is a new, ultra high-speed and high-resolution instrument available for clinical evaluation of optic nerve. The purpose of the study was to compare the agreements between SOCT and Heidelberg retinal tomography (HRT).

Methods: A total of 44 healthy normal volunteers were recruited in this study.

[Significance of optic disc topography and retinal nerve fiber layer thickness measurement by spectral-domain OCT in diagnosis of glaucoma].

Objective: To study the significance of optic disc tomography and retinal nerve fiber layer (RNFL) thickness measurement by spectral-domain optical coherence tomography (OCT) in the diagnosis of glaucoma.

Methods: It was a noninterventional, observational study. The optic disc topographic parameters and total and regional RNFL thickness were measured by RTVue OCT in 60 normal eyes and 97 glaucomatous eyes.

Reproducibility of RTVue retinal nerve fiber layer thickness and optic nerve head measurements in normal and glaucoma eyes.

Background: RTVue spectral-domain optical coherence tomography (OCT) is a new, ultra high-speed and high-resolution instrument, potentially to measure the presence of glaucoma or its progression accurately. The objective of this study was to evaluate its reproducibility of retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements in normal and glaucoma eyes.

Methods: This study was an observational clinical study.

Measurement of anterior chamber volume with rotating scheimpflug camera and anterior segment optical coherence tomography.

Background: Measurement of anterior segment parameters plays an important role in diagnosis and treatment of glaucoma. The objective of this study was to evaluate the repeatability and reproducibility of anterior chamber volume (ACV) measurements with rotating scheimpflug camera (RSC) and to examine agreement with anterior segment optical coherence tomography (AS-OCT).

Methods: Thirty nine healthy normal subjects were recruited from the Eye Center of Tongren Hospital.

[Clinical research on movement of intraocular contact lens during accommodation].

Objective: To study the movement of intraocular contact lens (ICL) during accommodation.

Methods: Forty one eyes of 41 consecutive patients implanted ICL to correct high myopia were collected. The visual acuity and accommodation power were checked before and after the surgery.

Accuracy and repeatability of direct ciliary sulcus diameter measurements by full-scale 50-megahertz ultrasound biomicroscopy.

Background: Phakic intraocular lens (pIOL) implantation has been a popular means for the treatment of high ametropia. Measurements of ciliary sulcus diameter is important for pIOL size determining. But till now, no perfect system can directly measure it.

[The experimental study of effect of pressure on rat retinal Muller cell in vitro].

Objective: To observe the changes of morphology, activity and ability of metabolizing glutamate in Muller cell and investigate the role of Muller cell in the damage induced by glaucoma.

Method: Cultured Muller cells were divided into two groups at random, one was control group without any treatment, in the experimental group the cells were cultured under pressure of 50 mm Hg (1 mm Hg = 0.133 kPa) for 1 hour, after 3 days additional incubation, the morphology of the cells in two groups was observed by inverse phase microscope and electron microscope, the cells survival were evaluated by MTT colorimetry assay and the expression of mRNA of glutamine synthetase was semi-quantified by RT-PCR.