CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma.

The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved in cancer cell metabolic processes remains largely unknown. Here, we reported that circRNA, circHIPK3, is highly expressed in ESCC cell lines and tissues.

[Clinical observation of gelfoam in preventing cement leakage via the anterior vertebral wall in Kümmell's patients treated with percutaneous kyphoplasty].

Objective: To evaluate the efficacy of gelfoam granules application in prevention of cement leakage via anterior vertebral wall in Kümmell's patients treated with percutaneous kyphoplasty (PKP).

Methods: From June 2017 to December 2019, 13 patients with Kümmell disease were treated with PKP, and gelatin sponge was inserted into the anterior wall of vertebral body to prevent bone cement leakage. There were 3 males and 10 females, with an average age of (73.

microRNA-148a inhibits hepatocellular carcinoma cell invasion by targeting sphingosine-1-phosphate receptor 1.

microRNA (miR)-148a has been shown to act as an important suppressor in numerous human malignancies and is markedly downregulated in hepatocellular carcinoma; however, the role of miR-148a in the regulation of hepatocellular carcinoma cell invasion, as well as the underlying mechanism, has never been studied. In the present study, the expression level of miR-148a was found to be significantly decreased in hepatocellular carcinoma tissues and HepG2 cells when compared with that in the normal adjacent tissues. Furthermore, a novel target of miR-148a was found, sphingosine-1-phosphate receptor 1 (S1PR1), whose expression was negatively regulated by miR-148a at a post-transcriptional level in hepatocellular carcinoma HepG2 cells.

[A biomechanical comparison of Acutrak headless compression screw and AO cannulated lag screw for the fixation of Hoffa fracture].

Objective: To compare the stability, strength of Letenneur type I Hoffa fractures fixed by Acutrak headless compression screws and AO cannulated lag screws.

Methods: 12 models of Letenneur type I Hoffa fractures were randomly divided into 4 groups, which were fixed with two AO cannulated lag screws or Acutrak headless compression screws anteroposteriorly or posteroanteriorly. The stress between two fragments of all specimens was tested.

[Repairing bone defect with nano-hydroxyapatite and polyamide 66 composite after giant cell tumor operations].

Objective: To evaluate the clinical effectiveness and safety of using granular type nano-hydroxyapatite and polyamide 66 (n-HA/PA66) composite in repairing bone defects caused by giant cell tumors.

Methods: 48 patients with giant cell tumors, who underwent lesion curettage, inactivation and cavities fill-in with granular type n-HA/PA66 from December 2007 to May 2011, were followed up. Routine blood tests, liver and kidney functions, serum calcium and phosphorus, and immunologic parameters were examined before and after the surgeries.

[Finite element analysis on fracture relevance as bone defect of proximal femur].

Objective: Based on establishment three-dimensional finite element models with the different defects of proximal femur, analysis of the local stress and strain changes under normal walking condition, speculate the probable rang of fracture and provide a theoretical basis for clinical work.

Methods: By CT scanning the whole femur, establish Three-dimensional finite element models were established with analogous to the loaded lower extremity under normal walking condition. The stress distribution of the zone of lesser trochanter, intertrochanter and femur neck were analyzed.