Heterozygous CAPZA2 mutations cause global developmental delay, hypotonia with epilepsy: a case report and the literature review.

CAPZA2 encodes the α2 subunit of CAPZA, which is vital for actin polymerization and depolymerization in humans. However, understanding of diseases associated with CAPZA2 remains limited. To date, only three cases have been documented with neurodevelopmental abnormalities such as delayed motor development, speech delay, intellectual disability, hypotonia, and a history of seizures.

[Clinical characteristics and risk factors for early-onset necrotizing enterocolitis in preterm infants with very/extremely low birth weight].

Objectives: To investigate the clinical characteristics and risk factors for early-onset necrotizing enterocolitis (NEC) in preterm infants with very/extremely low birth weight (VLBW/ELBW).

Methods: A retrospective analysis was performed on the medical data of 194 VLBW/ELBW preterm infants with NEC who were admitted to Children's Hospital Affiliated to Zhengzhou University from January 2014 to December 2021. These infants were divided into early-onset group (onset in the first two weeks of life; =62) and late-onset group (onset two weeks after birth; =132) based on their onset time.

Artificial microbial consortium producing oxidases enhanced the biotransformation efficiencies of multi-antibiotics.

Antibiotic mixtures in the environment result in the development of bacterial strains with resistance against multiple antibiotics. Oxidases are versatile that can bio-remove antibiotics. Various laccases (LACs), manganese peroxidases (MNPs), and versatile peroxidase (VP) were reconstructed in Pichia pastoris.

Co-culture of Bacillus amyloliquefaciens and recombinant Pichia pastoris for utilizing kitchen waste to produce fengycins.

Kitchen waste (KW) is a vast potential source of fermentable substrates. To bio-convert the KW into high-value chemicals, we used KW as substrate for the production of fengycin by an artificial consortium containing Bacillus amyloliquefaciens HM618 producing fengycin and the engineering Pichia pastoris producing amylase, glucosidase, or lipases. The maximal amylase activity of the constructed amylase-producing engineering strain (recombinant P.

Improved the lipopeptide production of Bacillus amyloliquefaciens HM618 under co-culture with the recombinant Corynebacterium glutamicum producing high-level proline.

The application of antibacterial lipopeptides is limited by high cost and low yield. Herein, the exogenous L-proline significantly improved lipopeptide production by Bacillus amyloliquefaciens HM618. A recombinant Corynebacterium glutamicum producing high levels of proline using genetically modifying proB and putA was used to establish consortium, to improve lipopeptide production of strain HM618.

[Magnetic Responses of Heavy Metals in Street Dust of Typical Mine-Based City, Northwest China].

Magnetic characteristics and heavy metal properties of 43 street dust samples collected from Baiyin City, northwest of China were systematically analyzed. The results revealed that the main magnetic minerals were low-coercivity magnetite and maghemite with coarse pseudo single domain (PSD) and multi-domain (MD) in magnetic grain size. Compared with the domestic comprehensive cities, low frequency magnetic susceptibility(χlf) value of street dust samples in Binyin varied from 43.

Event-related potentials in response to emotional words in patients with major depressive disorder and healthy controls.

Background: Dysfunctional cognitive processing and abnormal brain activation in response to emotional stimuli have long been recognized as core features of the major depressive disorder (MDD). The aim of this study was to examine how Chinese patients with MDD process Chinese emotional words presented to either the left (LH) or right hemisphere (RH).

Methods: Reaction time (RT) and the late positive component of the event-related potential were measured while subjects judged the valence (positive or negative) of emotional words written in Chinese.

[Magnetic properties of topsoils in typical industrial belt along the Yellow River in arid regions in northwest China and their environmental significance].

We have carried out environmental magnetic investigation on topsoil samples of two industrial cities Wuhai and Shizuishan along the Yellow River in the arid regions in northwest China. The concentration, type, magnetic grain sizes of the magnetic minerals and the environmental significance were discussed. The results showed that the main magnetic grain sizes were multi-domain (MD) and pseudo single domain (PSD).

Serum 25(OH)D Level and Parathyroid Hormone in Chinese Adult Population: A Cross-Sectional Study in Guiyang Urban Community from Southeast of China.

Objective. To evaluate vitamin D status and serum parathyroid hormone (IPTH) of healthy adults living in Guiyang. Design and Participants.

[An epidemiological survey of the prevalence of thyroid diseases in mild iodine deficiency city after salt iodization].

Objective: To investigate the current status of iodine nutrition and the prevalence of thyroid diseases in Guiyang, a mild iodine deficiency city practiced salt iodization for 25 years.

Methods: A representative sample of 1509 adults aged 20 years old or above in Guiyang, selected by a multistage stratified sampling method, participated in the study. After an overnight fasting, serum thyroid hormones, serum thyroid autoantibodies, and urine iodine were measured.

[Effect of UGTIA6 A541G genetic polymorphism on the metabolism of valproic acid in Han epileptic children from Henan].

Objective: To investigate the distribution and frequency of UGTIA6 A541G genetic polymorphism in Han epileptic children from Henan and to evaluate the effect of UGTIA6 A541G genetic polymorphism on serum concentrations of valproic acid.

Methods: The method of gas chromatography was used to assay serum concentrations of valproic acid. UGTIA6 A541G genetic polymorphism was screened by PCR-RFLP.

[Identification and expression a D-amino acid dehydrogenase gene from Pseudomonas fluorescens TM5-2].

In the previous study we have isolated DNA fragment containing an alanine racemase gene (dadX) from Pseudomonas fluorescens TM5-2. Adjacent to dadX one ORF similar to a putative glycine/D-amino acid oxidase gene have been found. The same gene organization is found in several Pseudomonas species.