Publications by authors named "Shu-jia Liang"
Article Synopsis
- The study focused on analyzing genetic subtypes of HIV and the rate of drug resistance in newly diagnosed HIV-infected men aged 50 or older in Guangxi from January to June 2020.
- Out of 615 participants, the majority were infected with the HIV subtypes CRF01_AE, CRF07_BC, and CRF08_BC, with a total of 22 patients showing resistance to at least one type of antiretroviral drug.
- The research found that pretreatment resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) was more common than to nucleoside reverse transcriptase inhibitors (NRTIs), indicating a generally low prevalence of drug resistance among this population
Background: After the scale-up of antiretroviral therapy (ART) for HIV infected people, increasing numbers of patients have pretreatment drug resistance (PDR). In this study, the prevalence of PDR was evaluated in adults initiating antiretroviral therapy in China.
Methods: Blood samples were obtained from 1943 patients who initiated antiretroviral therapy (ART) in 2017 from 13 provinces or cities in China.
Objectives: We aimed to determine the prevalence of hepatitis B virus (HBV) drug-resistant mutations in patients co- infected with HBV/human immunodeficiency virus (HIV), including both drug-naïve subjects and those who received antiretroviral therapy (ART) in Guangxi, where the prevalence of HIV/HBV co-infection is highest in China.
Methods: Two hundred and three subjects co-infected with HBV/HIV were recruited, including 123 drug-naïve patients (group 1) and 80 who received ART (group 2). The polymerase gene of HBV in the serum of all study subjects was analysed.
Article Synopsis
- The study analyzed HIV-1 subtype CRF01_AE among newly diagnosed adolescents and young adults in Guangxi Province, China, focusing on drug resistance and cluster distribution from 2009 to 2013.
- A total of 216 sequences were identified, showing significant clustering in Hezhou (mainly cluster 2) and Liuzhou (predominantly cluster 1), while Nanning exhibited a more even distribution of clusters.
- The research discovered key transmitted drug resistance mutations, with the most common being M46I and Y181C, indicating a critical landscape for HIV treatment strategies in the region.
[Distribution of HIV-1 subtypes in Guangxi Zhuang Autonomous Region, 2008-2009].
Zhonghua Liu Xing Bing Xue Za Zhi
January 2013
Objective: To understand the distribution of HIV-1 subtypes in Guangxi Zhuang Autonomous Region.
Methods: 294 participants who were infected by HIV-1 in 2008 - 2009 and residing in 13 cities in Guangxi were enrolled into this study. Epidemiological information showed that heterosexual transmission was the main transmitting route.
Objective: To investigate the changes of the T lymphocytes and their subsets before and after receiving highly active anti-retroviral therapy (HAART) in children who were infected with HIV or AIDS patients.
Methods: Ninety-nine children met the criteria were recruited. All of them had received HAART in Guangxi Center for Disease Control and Prevention from May 2006 to April 2009.
[Genetic characteristics of HIV-1 CRF01_AE strains in four provinces, southern China].
Zhonghua Liu Xing Bing Xue Za Zhi
July 2009
Article Synopsis
- The study aimed to analyze the genetic characteristics of HIV-1 CRF01_AE strains in southern China, focusing on four provinces: Guangdong, Guangxi, Jiangxi, and Hunan.
- Plasma samples from newly diagnosed individuals were collected in 2006, and genetic analysis revealed two major epidemic clusters among the strains, one closely related to Vietnam and another unique to the region.
- Findings indicated that cluster I was dominant in southern China, characterized by lower genetic diversity, while cluster II showed higher diversity and significant nucleotide differences, suggesting unique features affecting their transmission.
[Study on the antiviral therapy program among people with human immunodeficiency virus in Guangxi Zhuang Authority].
Zhonghua Liu Xing Bing Xue Za Zhi
April 2007
Objective: To explore the reconstitution of immune function and viral suppression condition and to analyze the occurrence of drug resistance HIV-1 variants and its prevalence after using HAART in Guangxi Autonomy Region.
Methods: From July 2004 to October 2005, 133 HIV infected individuals who had received HAART for more than three months were recruited, and 58 infected persons with no antiviral therapy were selected as controls. Questionnaire was used to collect information about the adherence of HAART therapy.