Porphyrin photosensitizer molecules as effective medicine candidates for photodynamic therapy: electronic structure information aided design.

Traditional photosensitizers (PS) in photodynamic therapy (PDT) have restricted tissue penetrability of light and a lack of selectivity for tumor cells, which diminishes the efficiency of PDT. Our aim is to effectively screen porphyrin-based PS medication through computational simulations of large-scale design and screening of PDT candidates a precise description of the state of the light-stimulated PS molecule. Perylene-diimide (PDI) shows an absorption band in the near-infrared region (NIR) and a great photostability.

Preclinical ImmunoPET Imaging Using a Zr-89-Labeled Anti-CD146 Monoclonal Antibody for Diagnosis of Melanoma.

The aim of this study was to evaluate the preclinical efficacy of [Zr]Zr-DFO-Ab253 as a novel positron emission tomography (PET) tracer for CD146-positive malignant melanoma imaging. Considering the high expression of CD146 in malignant melanoma, this study investigated the effect of different CD146 expression levels on the tumor uptake of [Zr]Zr-DFO-Ab253. CD146 selectivity was investigated by using the CD146-positive human melanoma cell A375 and the CD146-negative human alveolar epithelial cell A549.

Optimized microbial fuel cell-powered electro-Fenton processes to enhance electricity and bisphenol A removal by varying external resistance and electrolyte concentrations.

This study is the first to investigate the effects of external resistance and electrolyte concentration on the performance of a bioelectro-Fenton (BEF) system, involving measurements of power density, HO generation, and bisphenol A (BPA) removal efficiency. With optimized operating conditions (external resistance of 1.12 kΩ and cathodic NaCl concentration of 1,657 mg/L), the BEF system achieved a maximum power density of 38.

Optimized combination of zero-valent iron and oxygen-releasing biochar as cathodes of microbial fuel cells to enhance copper migration in sediment.

Membrane-less single-medium sediment microbial fuel cells (single-SMFC) can remove Cu from sediment through electromigration. However, the high mass transfer resistance of the sediment and amount of oxygen at the cathode of the SMFC limit its Cu removal ability. Therefore, this study used an oxygen-releasing bead (ORB) for slow oxygen release to increase oxygen at the SMFC cathode and improve the mass transfer property of the sediment.

A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody-Drug Conjugate for Targeting Melanoma.

Unlabelled: Recent advances in targeted therapy and immunotherapy have substantially improved the treatment of melanoma. However, therapeutic strategies are still needed for unresponsive or treatment-relapsed patients with melanoma. To discover antibody-drug conjugate (ADC)-tractable cell surface targets for melanoma, we developed an atlas of melanoma cell surface-binding antibodies (pAb) using a proteome-scale antibody array platform.

Sensitivity and reusability of a simple microbial fuel cell-based sensor for detecting bisphenol A in wastewater.

Polycarbonate plastic processing wastewater contains high concentrations of bisphenol A (BPA), requiring a real-time technology to monitor wastewater containing BPA. Since the activity of electrogenic microorganisms on the anode surface of the microbial fuel cell (MFC) sensor is inhibited by exposure to contaminants, the toxicity of contaminants in wastewater can be determined by observing the variation in voltage output from the MFC sensor. The simple MFC sensor that is developed in this work exhibited a significant decrease in voltage output in BPA-containing wastewater concentration of 5-100 mg/L.

Effects of biodegradation, biotoxicity and microbial community on biostimulation of sulfolane.

To evaluate the effectiveness of biostimulation in remediating soil-free groundwater and groundwater with soil, experiments were conducted using soil and groundwater samples that were contaminated with sulfolane. The main objective was to characterize the differences in sulfolane removal efficiency and biotoxicity between in situ soil-free groundwater and groundwater with soil and different concentrations of dissolved oxygen (1 mg/L and 5 mg/L) and various nutrient salts (in situ and spiked). Optimizing the nutrient salt conditions improved the removal efficiency of sulfolane by 1.

Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer.

Unlabelled: Antibody-drug conjugates (ADC) using DNA topoisomerase I inhibitor DXd/SN-38 have transformed cancer treatment, yet more effective ADCs are needed for overcoming resistance. We have designed an ADC class using a novel self-immolative T moiety for traceless conjugation and release of exatecan, a more potent topoisomerase I inhibitor with less sensitivity to multidrug resistance (MDR). Characterized by enhanced therapeutic indices, higher stability, and improved intratumoral pharmacodynamic response, antibody-T moiety-exatecan conjugates targeting HER2, HER3, and TROP2 overcome the intrinsic or treatment resistance of equivalent DXd/SN-38 ADCs in low-target-expression, large, and MDR+ tumors.

Performance of bioelectrochemical systems in treating exhaust gas with power generation: Effects of shock-load, shut-down episodes and microbial community.

A diffusive packed anode-bioelectrochemical (Dpa-Bes) system was constructed by feeding waste gas from the cathode to the anode tank in DPa-Bes through a proton exchange membrane (PEM). The high removal of oxygen by the PEM and the effective combination of the two packing materials reduced the electron loss and enhanced the proton transfer capacity, promoting the removal of acetone from the exhaust gas and increasing the output power. The maximum acetone removal efficiency of the modified Dpa-Bes reached ∼99 % after seven days of closed-circuit operation, with a 3.

Performance of a packed-bed anode bio-electrochemical reactor for power generation and for removal of gaseous acetone.

The packed anode bioelectrochemical system (Pa-BES) developed in this study is a type of BES that introduces waste gas into a cathode and then into an anode, thereby providing the cathode with sufficient oxygen and reducing the amount of oxygen to the anode to promote the output of electricity. When the empty-bed residence time was 45 s and the liquid flowrate was 35 mL/s, the system achieved optimal performance. Under these conditions, removal efficiency, mineralization efficiency, voltage output, and power density were 93.

Waste expanded polystyrene modified with HSO/biodegradable chelating agent for reuse: As a highly efficient adsorbent to remove fluoroquinolone antibiotic from water.

Untreated wastewater containing fluoroquinolone antibiotics poses serious hazards to aquatic species and human health; therefore, treatment of waste expanded polystyrene (EPS) is a crucial environmental matter. In this study, waste EPS was modified with a HSO/biodegradable chelating agent, [S,S]-ethylenediamine-N,N'-disuccinic acid (EDDS), and used for highly efficient adsorption of the fluoroquinolone antibiotic ciprofloxacin. When ciprofloxacin of 25 mg/L was used, the HSO-modified EPS (EPS) adsorbed 60.

Gaseous isopropanol removal in a microbial fuel cell with deoxidizing anode: Performance, anode characteristics and microbial community.

A deoxidizing packing material (DPM) with an encapsulated deoxidizing agent (DA) was developed to construct the packed anodes of a trickle-bed microbial fuel cell (TB-MFC) for treating waste gas. The encapsulated DA can consume O in waste gas and increase the voltage output and power density (PD) of the constructed TB-MFC. The DPM effectively enables the circulating water in TB-MFC for maintaining a low level of dissolved oxygen for 80 h.

Enhancement of isopropanol removal with concomitant power generation by microbial fuel cells: Optimization of deoxidizing composite anodes using response surface methodology.

This study used a response surface method to develop a deoxidizing anode, which was introduced into microbial fuel cells (MFCs) to treat isopropanol (IPA) wastewater and waste gas. By embedding a deoxidizing agent (DA) into the anode of MFCs, a hypoxic environment can be created to enable anaerobic electrogens to be effectively attached to the anode surface and grow. Consequently, MFC power generation performance can be enhanced.

[Driving Cessation and Mental Health in Persons With Dementia: A Preliminary Study].

Background: The driving safety of persons with dementia (PwD) is an important public-health issue worldwide. Driving is closely related to personal autonomy, self-esteem, and independence. When PwD lose their driving privileges, this may lead to negative effects on mental health.

Improving the performance of biotrickling filter microbial fuel cells in treating exhaust gas by adjusting the oxygen content of the anode tank.

A biotrickling filter (BTF) was combined with a microbial fuel cell (MFC) to remove ethyl acetate from exhaust gas while generating electricity in the process. The results indicated that the use of carbide porous ceramic rings (CPCR) as auxiliary anodes produced more biomass and exhibited a high average removal efficiency (98%), making it a superior microorganism growth carrier compared with carbon coke. When CPCR was used as the cathode in the BTF-MFC, the maximum power density (PD) was 5.

Rapid modification of waste expanded polystyrene with HSO/trace persulfate in one pot for effective adsorption of fluoroquinolone antibiotic and its regeneration.

Norfloxacin, a fluoroquinolone antibiotic, is widely used to treat microbial infections. However, untreated norfloxacin-containing wastewater poses serious threats to the ecosystem and human health. The treatment of waste expanded polystyrene (EPS) by landfilling or incineration could cause environmental problems.

Critical factors for enhancing the bioremediation of a toxic pollutant at high concentrations in groundwater: Toxicity evaluation, degrader tolerance, and microbial community.

Groundwater near refinery and natural gas plants often contain elevated concentrations of toxic sulfolane. Studies on any concentration of sulfolane are limited. Column experiment was conducted to investigate the effects of adding a low dose of HO and nutrient on bioremediation.

One-Pot CuI/DBU-Catalyzed Carboxylative Cyclization toward Oxazolidinones Using Recyclable Molecular Sieves as Efficient Promoters for Fixation of CO in Water Medium.

An efficient one-pot synthesis of oxazolidinones was developed through CuI/DBU/MS joint system-catalyzed carboxylative cyclization of arylacetylene, arylaldehyde, and arylamine in water medium under a 1 atm carbon dioxide (CO) atmosphere. The 4 Å molecular sieves (MSs) were added to improve CO capture and facilitate carboxylation to give the products in high yields. The CuI/DBU/MS system is robust and highly effective for the reactions with different substrates, and some target products were obtained in an excellent yield of ∼96%, with no side products in the final step.

α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition.

α-Linolenic acid (ALA), an essential fatty acid, has anticancer activity in breast cancer, but the mechanism of its effects in triple-negative breast cancer (TNBC) remains unclear. We investigated the effect of ALA on Twist1, which is required to initiate epithelial-mesenchymal transition (EMT) and promotes tumor metastasis, and Twist1-mediated migration in MDA-MB231, MDA-MB468 and Hs578T cells. Twist1 protein was constitutively expressed in these TNBC cells, particularly MDA-MB-231 cells.

Kinetics of biocathodic electron transfer in a bioelectrochemical system coupled with chemical absorption for NO removal.

A microbial electrolysis cell (MEC) has been developing for enhanced absorbent regeneration in a chemical absorption-biological reduction integrated process for NO removal. In this work, the kinetics of electron transfer involved in the biocathodes along Fe(III)EDTA and Fe(II)EDTA-NO reduction was analyzed simultaneously. A modified Nernst-Monod kinetics considering the Faraday efficiency was applied to describe the electron transfer kinetics of Fe(III)EDTA reduction.

Enhancement of power generation with concomitant removal of toluene from artificial groundwater using a mini microbial fuel cell with a packed-composite anode.

Composite beads are packed in the anode chamber of a microbial fuel cell (MFC), providing more area for microbial attachment and growth, increasing the efficiency of removal of toluene from toluene-contaminated groundwater. The composite beads were fabricated by integrating carbon coke (CC) with a relatively large specific surface area to which microorganisms easily adhere with conductive carbon black (CCB), which has low electrical resistance. Since the advantages of both are complementary, the power generation of MFC is improved.

Inducing laccase activity in white rot fungi using copper ions and improving the efficiency of azo dye treatment with electricity generation using microbial fuel cells.

This work presents a white rot fungus-microbial fuel cell (WRF-MFC) that uses WRF that is grown at its cathode. Adding Cu to the fungi-containing solid medium stimulated WRF-secreting laccase, which catalyzed the redox reaction in the MFC and thereby promoting the generation of electricity. Adding 12.

Author Correction: Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Regular exercise and the trajectory of health-related quality of life among Taiwanese adults: a cohort study analysis 2006-2014.

Background: Physical activity is related to health-related quality of life, but little evidence from multiple waves of panel data in Asian countries area available. This study aims to explore the impacts of different degree of regular exercise on the trajectories of physical and mental dimensions of health-related quality of life (HRQOL) for community-dwelling Taiwanese adults during 2006-2014.

Methods: Data were derived from the "Landseed Integrated Outreaching Neighborhood Screening (LIONS)" study, with 6182 adults enrolled at the baseline and subsequently followed up to three times till 2014.