Graphene oxide linked sulfonate-based polyanionic nanogels as biocompatible, robust and versatile modifiers of ultrafiltration membranes.

Aiming to enhance the current biological performances of ultrafiltration membranes, in this study, a new kind of graphene oxide linked sulfonate-based polyanionic nanogel (GO-SPN) was fabricated by free radical cross-linked copolymerization. Then, GO-SPN embedded polyethersulfone (PES/GO-SPN) ultrafiltration (UF) membranes were achieved through one-pot PES dissolution and interpenetration, followed by a liquid-liquid phase inversion method. The GO-SPN modified UF membranes exhibited increased porous cross-section structures with a pH-dependent water flux.

Graphene oxide and sulfonated polyanion co-doped hydrogel films for dual-layered membranes with superior hemocompatibility and antibacterial activity.

In this study, a new kind of hemocompatible and antibacterial dual-layered polymeric membrane was fabricated by coating a top layer of graphene oxide and a sulfonated polyanion co-doped hydrogel thin film (GO-SPHF) on a bottom membrane substrate. After a two-step spin-coating of casting solutions on glass plates, dual-layered membranes were obtained by a liquid-liquid phase inversion method. The GO-SPHF composite polyethersulfone (PES) membranes (PES/GO-SPHF) showed top layers with obviously large porous structures.

Zwitterionic polymer functionalization of polysulfone membrane with improved antifouling property and blood compatibility by combination of ATRP and click chemistry.

The chemical compositions are very important for designing blood-contacting membranes with good antifouling property and blood compatibility. In this study, we propose a method combining ATRP and click chemistry to introduce zwitterionic polymer of poly(sulfobetaine methacrylate) (PSBMA), negatively charged polymers of poly(sodium methacrylate) (PNaMAA) and/or poly(sodium p-styrene sulfonate) (PNaSS), to improve the antifouling property and blood compatibility of polysulfone (PSf) membranes. Attenuated total reflectance-Fourier transform infrared spectra, X-ray photoelectron spectroscopy and water contact angle results confirmed the successful grafting of the functional polymers.

Covalent deposition of zwitterionic polymer and citric acid by click chemistry-enabled layer-by-layer assembly for improving the blood compatibility of polysulfone membrane.

Development of blood compatible membranes is critical for biomedical applications. Zwitterionic polymers have been proved to be resistant to nonspecific protein adsorption and platelet adhesion. In this work, two kinds of zwitterionic copolymers bearing alkynyl and azide groups are synthesized by atom transfer radical polymerization (ATRP) and subsequent reactions, namely alkynyl-poly(sulfobetaine methacrylate) (alkynyl-PSBMA) and azide-poly(sulfobetaine methacrylate) (azide-PSBMA).

Surface hydrophilic modification of polyethersulfone membranes by surface-initiated ATRP with enhanced blood compatibility.

Surface-initiated atom transfer radical polymerization (SI-ATRP) was used to tailor the functionality of polyethersulfone (PES) membranes. A two-step method including nitration reaction and amination reaction was used to synthesize aminated polyethersulfone (PES-NH2) for the preparation of PES/PES-NH2 membranes. Covalently tethered hydrophilic polymer brushes of poly(N-vinylpyrrolidone) (PVP) were prepared via SI-ATRP at low temperature in an aqueous solvent.

[The comparisive study of the clinical effect of rotary self-locking intramedullary nail and intramedullary interlocking nail for the treatment of femur fracture].

Objective: To compare the clinical effect of rotary self-locking intramedullary nail (RSIN) and intramedullary interlocking nail (IIN) for the treatment of fresh femoral shaft fracture.

Methods: The radiological records of 60 fresh femoral shaft fractures (41 stable fractures and 19 unstable fractures) were retrospectively analyzed. Among them, 49 were male and 11 were female.

[Effect of blood purification materials and anticoagulants on the contact activity of factor XI].

Objective: This study was conducted to examine the degree of contact activation of five blood purification materials sulfonated polyethersulfone (PES-SO3Na), polyethersulfone (PES), polysulfone (PS), polymethylmethacrylate (PMMA) and cellulose acetate (CA) after they were incubated in anticoagulant-containing human plasma for 10 minutes at 37 degrees C.

Methods: Three anticoagulants Heparin, Trisodium citrate and Disodium EDTA were used. The time course for generation of FXII activity by the materials after incubation in anticoagulant-containing human plasma was evaluated.