Publications by authors named "Shu-bin Wang"
Article Synopsis
- This study investigates the role of interleukin 23 receptor in intrahepatic cholangiocarcinoma (CHOL), a type of cancer with a poor prognosis, using bioinformatics and experimental methods.
- Researchers analyzed datasets from various databases and performed functional enrichment analyses to understand how different RNAs interact and affect CHOL.
- Key findings suggest that interleukin 23 receptor is linked to immune cell infiltration and may serve as a potential prognostic and immune-related biomarker for CHOL, warranting further research.
Laparoscopic treatment of bilateral duplex kidney and ectopic ureter: A case report.
World J Clin Cases
August 2022
Article Synopsis
- Duplication of the renal pelvis is a common birth defect, with most cases being complete unilateral, while bilateral cases are rare.
- A 6-year-old girl with long-term vaginal leakage was diagnosed with bilateral renal duplication and an ectopic ureter-vaginal fistula, leading to laparoscopic surgery for treatment.
- Following the procedure, the patient showed no damage to renal function or vaginal leakage during a two-year follow-up, showcasing the effectiveness of minimally invasive surgery in such cases.
Article Synopsis
- Supracondylar humerus fractures are common in children, and this study presents a new surgical technique for treating them.
- The modified method was applied to 73 pediatric patients, with 68 followed for an average of over 8 months, evaluating outcomes like bone healing and complications.
- The results indicated successful bone union in all cases, minimal complications, and a 100% satisfaction rate, showing the effectiveness of the modified treatment approach.
Article Synopsis
- The study aims to assess the psychological distress experienced by patients with oral squamous cell carcinoma after surgery and the effects of radiotherapy on their quality of life.
- It employs univariate and regression analyses to identify factors influencing psychological distress, finding that age, cancer stage, and surgical incision location are significant contributors.
- The results highlight the need for personalized treatment plans for patients and emphasize the role of psychological support, noting that radiotherapy can both help and worsen certain symptoms.
Article Synopsis
- * A total of 248 young women (aged ≤50) were enrolled in a randomized, double-blind, placebo-controlled trial, receiving either the aprepitant regimen or a placebo regimen alongside standard anti-nausea medications.
- * The main outcome measured was the complete response rate, which indicates the percentage of patients who experienced no vomiting or need for rescue medication during the first cycle of chemotherapy.
Article Synopsis
- Cancer stem cells (CSCs) significantly contribute to colorectal cancer (CRC) development and treatment resistance, making them important targets for research.
- This study focuses on the expression of two markers, DCLK1 and Lgr5, in CRC patients to evaluate their potential as prognostic indicators for disease outcomes.
- Results show that high levels of DCLK1 and Lgr5 are linked to poorer survival rates and may indicate DCLK1 as a key factor for predicting CRC recurrence and overall patient survival.
[Expression and functions of long non-coding RNA actin filament-associated protein 1-antisense RNA1 in oral squamous cell carcinoma].
Hua Xi Kou Qiang Yi Xue Za Zhi
December 2019
Article Synopsis
- The study investigates the long non-coding RNA AFAP1-AS1 and its role in oral squamous cell carcinoma (OSCC), revealing higher expression levels in cancerous tissues compared to normal cells, indicating its potential as a biomarker.
- A correlation was found between high levels of AFAP1-AS1 and poor clinical outcomes, including lower survival rates and advanced disease characteristics like differentiation and lymphatic metastasis.
- Experimental silencing of AFAP1-AS1 led to reduced cell proliferation, invasion, and migration in OSCC cell lines, suggesting that targeting this lncRNA could be a promising therapeutic strategy for improving patient outcomes.
[Study of psychological distress and quality of life in patients with oral cancer].
Shanghai Kou Qiang Yi Xue
October 2018
Article Synopsis
- The study investigates how various factors, including age and treatment history, impact the quality of life and psychological distress in oral cancer patients.
- Out of 250 surveyed patients, a significant portion experienced high levels of distress, particularly those who were younger or had undergone more extensive surgeries like jaw resection.
- The findings suggest that emotional and physical well-being in these patients is closely linked, with negative correlations between psychological distress and quality-of-life metrics like pain and anxiety.
[Effects of large tumor suppressor homolog 2 gene overexpression on the proliferation and apoptosis of oral squamous cell carcinoma].
Hua Xi Kou Qiang Yi Xue Za Zhi
December 2018
Article Synopsis
- The study aimed to examine how overexpressing the LATS2 gene affects the growth and programmed cell death (apoptosis) of oral squamous cell carcinoma (OSCC) cells.
- Researchers used lentiviral particles to increase LATS2 levels in SCC-25 cells and measured changes in cell growth and apoptosis through various assays.
- Results showed that higher LATS2 expression slowed down SCC-25 cell growth and led to increased apoptosis by altering the levels of key proteins involved in cell survival.
Article Synopsis
- * The study involved analyzing MZF1 protein levels in different tissue samples and gastric cell lines through techniques such as immunohistochemical staining and quantitative PCR.
- * Results showed that lower MZF1 levels were linked to gastric cancer severity and poor patient outcomes, suggesting that MZF1 could serve as a valuable early predictive and prognostic biomarker for gastric cancer.
Article Synopsis
- STAT3 signaling is crucial in gastric cancer (GC) progression through its interaction with EZH2, which enhances STAT3 activity via increased tyrosine phosphorylation.
- Research showed that high levels of both STAT3 and EZH2 in GC tissues correlate with poor patient outcomes and advanced disease stages.
- Targeting the STAT3-EZH2 relationship may improve treatment effectiveness, as combining siSTAT3 with an EZH2 inhibitor increased cancer cell apoptosis.
[Review on scientific connotation of leech processed under high temperature].
Zhongguo Zhong Yao Za Zhi
October 2015
Article Synopsis
- Animal medicines, particularly leech, have protein structures that can undergo thermal denaturation when exposed to high temperatures, resulting in changes to their biological activity and properties.
- Traditional processing methods for leech, such as stir-frying with talc or wine, aim to manage toxicity and modify their pharmacological effects while being influenced by historical techniques.
- Processing leech at high temperatures can reduce toxic elements and alter active peptides, leading to increased anticoagulant and antithrombotic activities, suggesting future research should explore the scientific basis of these changes.
Article Synopsis
- The study focuses on the WRKY family of transcription factors, crucial for plant defense against environmental stresses, particularly in the pepper species (Capsicum annuum L.).
- Researchers identified a total of 71 WRKY genes in the pepper genome, categorizing them into three main groups and several subgroups based on their structure.
- The expression levels of 21 specific CaWRKY genes were analyzed under various stress conditions, revealing that some were significantly activated by these treatments, which could aid in future breeding and genetic research.
Article Synopsis
- * This study used fruit bagging as a shade stress method to investigate the color change characteristics and molecular mechanisms in peppers, isolating a gene called CarbcL that showed high similarity to the rbcL gene.
- * Silencing the CarbcL gene resulted in significant color changes in the fruit and lowered the chlorophyll and capsanthin content, indicating that CarbcL is important for the metabolic regulation of these pigments in pepper fruits.
Article Synopsis
- - The study investigates the CaHsp20 gene family in pepper (Capsicum annuum L.), identifying 35 putative genes that help plants cope with heat stress by preventing protein aggregation.
- - Analysis of gene expression in thermotolerant pepper line R9 revealed that most CaHsp20 genes have low expression under normal conditions but significantly increase during heat stress, with some genes showing tissue-specific responses.
- - Comparisons between thermotolerant and thermosensitive lines highlight differences in gene expression patterns under heat stress, suggesting that CaHsp20 genes play a critical role in heat stress defense and could inform future research on enhancing thermotolerance in peppers.
Article Synopsis
- The study identifies a new NAC transcription factor called CaNAC2 from Capsicum annuum, which is similar to a protein from Petunia and plays a role in plant development and stress regulation.
- CaNAC2 has a conserved NAC domain at its N-terminus and is mainly expressed in seeds and roots, with its expression increasing in response to cold, salt, and ABA treatments.
- Silencing CaNAC2 makes pepper seedlings more susceptible to cold stress and hampers leaf chlorophyll degradation under salt stress, suggesting its crucial role in abiotic stress tolerance in peppers.
Article Synopsis
- Researchers isolated the CaDHN1 gene from pepper (Capsicum annuum L.) and found it significantly upregulated in response to cold, salt, osmotic stresses, and salicylic acid (SA).
- Dehydrins (DHNs) like CaDHN1 are proteins linked to helping plants cope with environmental stresses, and the gene was characterized as belonging to the SKn subgroup based on its structure.
- Using a technique called virus-induced gene silencing (VIGS), the study demonstrated that disabling CaDHN1 reduces pepper plants' ability to tolerate various abiotic stresses.
Article Synopsis
- A study investigated how different levels of nitrogen (N) and winter green manure affect soil organic carbon (SOC) and other related metrics in a "winter green manure-double rice" cropping system.
- Results showed that using green manure alone increased soil active organic carbon (AOC) and SOC, while single N fertilization reduced SOC levels.
- The findings indicate that applying winter green manure along with N fertilizer can enhance soil quality and rice yields, highlighting the importance of balanced fertilization for better crop production.
Article Synopsis
- Plant aquaporins, like CaPIP1-1, facilitate water transport across cell membranes and are crucial for plant responses to environmental stressors.
- CaPIP1-1 was identified from a pepper species, showing a specific genetic structure similar to related plants and high expression in fruit, especially under stress conditions.
- Silencing CaPIP1-1 in pepper plants led to reduced growth and lower tolerance to salt and mannitol stress, indicating its critical role in stress response.
Article Synopsis
- The study aimed to investigate how electroacupuncture (EA) affects genes related to pain and emotion in the amygdala of rats with chronic nerve injury.
- Researchers used 36 male Wistar rats, creating different groups including a control, a chronic pain model, and an EA treatment group, to measure pain response and gene expression.
- Results showed that EA significantly decreased pain and altered the expression of pain-related genes, indicating its potential effectiveness in pain relief mechanisms.
Article Synopsis
- * Overexpression of CaTIP1-1 results in larger stomatal pores, which decreases chilling tolerance but improves growth in salt and mannitol conditions.
- * The gene's expression is strongly induced during salt and mannitol stress, and its silencing leads to reduced tolerance, indicating its crucial role in stress response.
Article Synopsis
- The text discusses two key concepts in acupuncture: man-spirit (RenShen) and bottom-spirit (KaoShen), which are time-related contraindications that can affect health.
- It explains that man-spirit is often associated with aspects like qi-blood, mind, and is linked to the concept of heaven-spirit (TianShen), while bottom-spirit is considered subordinate to it according to Taoist beliefs.
- The violation of these contraindications can lead to serious health issues, often noted in historical medical texts as ulcers, lingering diseases, or even death, and since the Ming dynasty, skepticism towards these concepts has grown among physicians.
Article Synopsis
- Pseudoroegneria is a small genus within the Triticeae tribe, notable for having its St genome in over half of the allopolyploid Triticeae species, yet its high molecular weight glutenin (HMW-GS) subunits are not well understood.
- The study identifies and characterizes fourteen unique alleles of HMW-GS genes from two Pseudoroegneria species, revealing they share a typical structure with known HMW-GS but have distinct modifications.
- These alleles are notably smaller than normal due to fewer repeat motifs and represent an intermediate evolutionary stage between x- and y-type subunits.
Article Synopsis
- The study aimed to compare the effectiveness of a comprehensive therapy (electroacupuncture, moxibustion, and cupping) against western medication (vitamin B1 and mecobalamine) for treating common peroneal nerve palsy.
- A total of 90 patients were divided into two groups, with the comprehensive therapy group showing a significantly higher improvement rate of 97.8% compared to 82.2% in the western medication group after two treatment sessions.
- Electrophysiological tests further indicated notable improvements in nerve function in the comprehensive therapy group, highlighting its greater efficacy over western medication for this condition.
[Effects of different multiple cropping systems on paddy field weed community under long term paddy-upland rotation].
Ying Yong Sheng Tai Xue Bao
September 2013
Article Synopsis
- This paper investigates how various multiple cropping systems impact weed growth and diversity in paddy-upland rotations over a long-term field study.
- The milk vetch-early rice-late maize rotation, specifically when intercropped with early soybean and late rice, showed the most effective results in reducing weed density and dominance.
- The key weed species identified were Monochoia vaginalis, Echinochloa crusgalli, and Sagittaria pygmae, with notable similarity in weed communities across different cropping systems, though some less dominant weeds can still cause damage.