Icetexane diterpenoids as Ca3.2 T-type calcium channel inhibitors from Salvia prattii and analgesic effect of their Semi-synthesized derivatives.

Ten new icetexane diterpenoids, salpratins E-N (1-10) and a known analogue (11) were characterized from Salvia prattii Hemsl. Structurally, 1 is the first 19(4 → 3)-abeo-icetexane diterpenoid featuring with a 6/7/6 ring system. The structures of isolated compounds were determined by comprehensive analyses of spectroscopic data, ECD calculation, and single-crystal X-ray diffraction.

Novel Meroterpenoids from : Highly Potent Late Na1.5 Sodium Current Inhibitors.

Hypulatones A and B ( and ), two racemic meroterpenoids possessing an unprecedented spiro[benzofuran-2,1'-cycloundecan]-4'-ene-4,6(5)-dione core, were characterized from . Compound was found to significantly inhibit the late current of Na1.5 (late , IC = 0.

Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca3.1 Low Voltage-Gated Ca Channel.

A hybrid of dearomatized isoprenylated acylphloroglucinol (DIAP) and monoterpenoid, hypatone A (), together with its biosynthetic analogues - is characterized from . Structurally, possesses an unprecedented spiro[bicyclo[3.2.