Antagonistic Effects of N-acetylcysteine on Mitogen-activated Protein Kinase Pathway Activation, Oxidative Stress and Inflammatory Responses in Rats with PM Induced Lung Injuries.

To evaluate the antagonistic effects of N-acetylcysteine (NAC) on mitogen-activated protein kinases (MAPK) pathway activation, oxidative stress and inflammatory responses in rats with lung injury induced by fine particulate matter (PM). Forty eight male Wistar rats were randomly divided into six groups: blank control group (C1), water drip control group (C2), PM exposed group (P), low-dose NAC treated and PM exposed group (L), middle-dose NAC treated and PM exposed group (M), and high-dose NAC treated and PM exposed group (H). PM suspension (7.