Publications by authors named "Shu-Yuan Gao"
Article Synopsis
- Hypohidrotic ectodermal dysplasia (HED) leads to reduced sweating, hair loss, and dental issues, with the ectodysplasin A (EDA) pathway influencing skin and hair development.
- EDA expression levels were found to be significantly higher in the ear skin of alpacas compared to their back skin, with let‑7b microRNA playing a crucial role in this variation and potentially affecting skin and hair follicle development.
- Let‑7b was identified as a target gene of EDA, suggesting that it downregulates EDA expression, thereby indicating a link between let‑7b and the regulation of hair growth in alpacas, which might relate to the characteristics of HED.
The young male alpaca ear and the back skins were used to investigate the effect of transforming growth factor receptor-β I (TGFβR I) on alpaca hair follicles and hair growth. The expression level and location of TGFβR I in alpaca ear and dorsal skin were detected through real-time quantitative PCR (RT-PCR) and paraffin section immunohistochemical technique (ICC-P). The results shown TGFβR I was lower expression in back skin compared to ear skin and the mean density of the positive reaction in ear skin was significantly higher than back skin.
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