Publications by authors named "Shu-Ying Xiao"
Loss of BACH1 improves osteogenic differentiation in glucocorticoid-induced hBMSCs through restoring autophagy.
BMC Musculoskelet Disord
August 2024
Article Synopsis
- Glucocorticoid-induced osteoporosis (GIOP) impacts bone health, and this study explores how the protein BACH1 influences bone stem cell differentiation and autophagy under glucocorticoid treatment.
- BACH1 levels decrease as human bone mesenchymal stem cells (hBMSCs) differentiate into osteoblasts, but are increased by dexamethasone (Dex), which also hinders their differentiation.
- Silencing BACH1 enhances osteoblast differentiation and autophagy in hBMSCs treated with Dex by activating the autophagy gene ATG7, indicating BACH1 as a potential target for GIOP therapy.
Identification of a novel missense eya4 mutation causing autosomal dominant non‑syndromic hearing loss in a chinese family.
Cell Mol Biol (Noisy-le-grand)
March 2019
The aim of this study was to identify the novel missense eya4 mutation which cause autosomal dominant non syndromic hearing loss In a Chinese family. Hearing loss is the most common sensory deficit in humans, but the middle-frequency sensorineural hearing loss (MFSNHL) is rare among hereditary non-syndromic hearing loss, and EYA4 is one of the genes reported to be associated with MFSNHL. A genetic analysis of a Chinese family with autosomal dominant non‑syndromic progressive hearing impairment was conducted and assessed.
View Article and Find Full Text PDFOur objective was to explore the best predictive timing of short-latency somatosensory evoked potentials (SLSEP) and brainstem auditory evoked potentials (BAEP) for unfavorable outcomes in patients with early stage severe stroke. One hundred fifty-six patients with acute severe supratentorial stroke were monitored according to SLSEP, BAEP, and the Glasgow Coma Scale (GCS) at 1-3 days and 4-7 days after the onset of stroke. All patients were followed up for outcomes at 6 months after onset using the modified Rankin Scale (mRS), with a score of 5-6 considered unfavorable.
View Article and Find Full Text PDFObjective: To evaluate the prognostic value of middle-latency somatosensory evoked potential (MLSEP) in comatose patients with acute severe supratentorial stroke, considering both unfavourable outcome and death.
Methods: Eighty-eight patients with acute severe supratentorial stroke underwent MLSEP, short-latency somatosensory evoked potential (SLSEP), Glasgow Coma Scale (GCS) and cerebral computed tomography (CCT) within 1 week from onset. MLSEP and SLSEP were recorded in 25 normal controls.
To explore the prognostic accuracy for unfavorable outcome with short-latency somatosensory evoked potential (SLSEP) and brainstem auditory evoked potential (BAEP) in patients with severe stroke, 100 acute severe supratentorial stroke patients [Glasgow Coma Scale, (GCS)