Publications by authors named "Shu-Ying Hu"
[Risk factors for ventilator-associated pneumonia in neonates and the changes of isolated pathogens].
Zhongguo Dang Dai Er Ke Za Zhi
December 2010
Article Synopsis
- The study aimed to analyze risk factors for neonatal ventilator-associated pneumonia (VAP) and changes in pathogens over eight years.
- The incidence of VAP in 2008 was found to be lower than eight years prior and correlated with factors like gestational age, birth weight, and duration of mechanical ventilation.
- The main pathogens identified were antibiotic-resistant Gram-negative bacteria, with a notable increase in Stenotrophomonas maltophilia and a decrease in Pseudomonas aeruginosa compared to previous years.
Vaccination with ultraviolet-attenuated cercariae of Schistosoma japonicum induced protective immunity against challenge infection in experimental animal models. Our preliminary study on the transcription levels of IFN-gamma and IL-4 in splenic CD4+ T cells revealed that attenuated cercariae elicited predominantly a Th1 response in mice at the early stage, whereas normal cercariae stimulated primarily Th2-dependent responses. Further analysis on the gene profile of the skin-draining lymph nodes demonstrated that the levels of IFN-gamma were significantly higher in vaccinated mice than those in infected mice at day 4, 7 and 14 post-vaccination or post-infection.
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