Publications by authors named "Shu-Xin Lin"
Arachidonic acid (AA) in the cell membrane produces a variety of metabolites by different enzymatic pathways. These lipid metabolites, along with other mediators, play an important role in the inflammatory processes. Many of them can bind directly to the receptors on the sensory endings and initiate electrical impulses to be transmitted to the central nervous system, causing reflex responses.
View Article and Find Full Text PDFN-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal antibody in immunohistochemistry and immunofluorescence assays to analyze the expression pattern of Ndrg2 protein in mouse embryos at various gestational ages and in a variety of adult mouse tissues.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to analyze the diagnostic characteristics of acute respiratory distress syndrome/multiple organ dysfunction syndrome (H-ARDS/MODS) at different altitudes and compare the efficacy of three scoring criteria for predicting outcomes.
- - Researchers grouped 540 cases based on altitude and evaluated the diagnostic criteria using ROC curves and regression analysis, finding that the Lanzhou criteria were more effective in higher altitude areas compared to two other criteria.
- - The results indicated that existing diagnostic criteria for ARDS/MODS may be inadequate above 1,500 meters, suggesting the need for updated criteria specifically tailored for high altitude conditions.
[Criteria suitable for diagnosis of acute respiratory distress syndrome/multiple organ dysfunction syndrome at moderately high altitude area].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
April 2005
Article Synopsis
- The study aims to evaluate how well current ARDS/MODS diagnostic criteria work at high altitudes compared to lower altitudes, specifically focusing on high-altitude cases (H-ARDS/MODS).
- Researchers analyzed 505 cases, dividing them into three groups based on altitude, and used various diagnostic criteria to assess outcomes and compare accuracy through ROC curves and other statistical measures.
- Results showed that the current ARDS/MODS criteria are less effective at high altitudes, especially emphasizing that the Lanzhou criteria may provide better diagnostic accuracy for patients living at elevations above 1,517 meters.
NDRG2 expression and mutation in human liver and pancreatic cancers.
World J Gastroenterol
December 2004
Aim: To investigate the expression of NDRG2 and mutation of the entire coding region of NDRG2 in human liver and pancreatic cancers, and to further discuss the possible causes of NDRG2 distinct expression patterns.
Methods: Reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze the expression of NDRG2 mRNA in 37 fresh cancer specimens (including 8 cases of pancreatic cancer and 29 cases of liver cancer) and adjacent normal tissues collected from clinical operation. In addition, mutation analysis of the whole coding region of NDRG2 in these cancers was examined by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP).
[Vasorelaxing effect of idoxifene on human internal mammary arteries].
Sheng Li Xue Bao
February 2004
The purpose of this study was to investigate the vasorelaxing effect and mechanism of idoxifene (a new estrogen receptor modulator) on human internal mammary artery (HIMA). HIMA segments were harvested from men during coronary artery bypass grafting surgery. Patients with diabetes mellitus, hypercholesterolemia, hypertension, or smoking habit were excluded.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare the diagnostic parameters of acute respiratory distress syndrome and multiple organ dysfunction syndrome (ARDS/MODS) at high altitude versus on the plains, evaluating the practicality of existing diagnostic criteria.
- A total of 360 cases were analyzed, divided into three groups based on altitude: a control group from the plains, and two high-altitude groups (1,517 m and 2,261-2,400 m).
- Results indicated significant differences in diagnostic criteria between low and high altitudes, with the altitude of 1,517 m identified as a critical threshold for diagnosing H-ARDS, suggesting that current criteria need adjustments for high-altitude contexts.