Publications by authors named "Shu-Xin Lei"
Delta like non-canonical Notch ligand 1 (DLK1), as a member of epidermal growth factor-like family, plays a critical role in somatic growth, tissue development and possibly tissue renewal. Though previous studies had indicated that DLK1 contributed to adipogenesis and myogenesis, it's still controversial whether DLK1 affects angiogenesis and how it interacts with Notch signaling with numerous conflicting reports from different models. Based on our preliminary finding that DLK1 expression was up-regulated in mice ischemic gastrocnemius and in the border zone of infarcted myocardium, we administered either recombinant DLK1 (rDLK1) or PBS in C57BL/6 mice after establishment of hindlimb ischemia (HLI) and myocardial infarction (MI), respectively.
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- - A series of new biphenyl compounds were created from natural biphenyl phytoalexins to find effective antifungal agents against four invasive fungi.
- - Compounds 23a, 23e, and 23h showed strong antifungal activity, outperforming the lead compound noraucuparin by up to 256 times, and were as effective as the well-known drug amphotericin B.
- - Compound 23h not only demonstrated improved fungicidal activity by disrupting fungal cell membranes but also had low toxicity to human cells and promising pharmacokinetic properties, highlighting the potential of natural sources in developing new antifungal treatments.