Effect of high mobility group box 1 pathway inhibition on gene expression in the prefrontal cortex of mice exposed to alcohol.

Introduction: The high mobility group box 1 (HMGB1) pathway plays a pivotal role in the development of alcohol-induced brain injury. Glycyrrhizinic acid (GlyA) is widely regarded as an inhibitor of HMGB1. The objective is to investigate the impact on gene expression in the prefrontal cortex,we sequenced the transcriptome in control, alcohol-exposed, and HMGB1-inhibited groups of mice.

[Interactive effects of irrigation regime and planting density on grain yield and water use efficiency in winter wheat].

To get an optimal irrigation regime and planting density for simultaneous improvement of grain yield (GY) and water use efficiency (WUE) in winter wheat, we examined the responses of 'Tainong 18' (with bigger ears) and 'Shannong 22' (with medium-sized ears) under four irrigation regimes, including 0, 45, 60, and 75 mm. Those two cultivars were planted at four densities: Tainong 18 at 135×10, 270×10, 405×10, and 540×10 plants·hm and Shannong 22 at 90×10, 180×10, 270×10, and 360×10 plants·hm. The interactive effects of irrigation regimes and plant densities on GY, water consumption characteristics, and WUE were investigated.

A protocol of systematic review and meta-analysis of Mozart's Music for drug-resistant epilepsy.

Background: This study will aim to assess the effectiveness of Mozart's Music (MM) for the management of patients with drug-resistant epilepsy (DRE).

Methods: In this study, we will search MEDLINE, EMBASE, Cochrane Library, Web of Science, CINAHL, Chinese Scientific Journal Database Information, WANGFANG, and China National Knowledge Infrastructure from their inauguration to March 1, 2020 without language and publication time restrictions. We will also identify other literature resources, such as reference lists of any related reviews.

[Stability of a winter wheat population with high yield and high resource use efficiency].

Using the winter wheat cultivar Tainong 18 as the experimental material, we analyzed yield stability from 2012 to 2016 under three different treatments: T(following typical local field management practices), T(high-yield: high nitrogen and water were supplied to foster high grain yield), and T(high-yield, high-efficiency: optimized field management including increasing plant density, reducing nitrogen input and delaying of the sowing date). Yield related phenotypic traits, including the number of ears on the main stem and tillers, leaf area index (LAI), photosynthetically active radiation (PAR) interception, dry matter accumulation and distribution, as well as grain yield, were analyzed over four seasons to determine their relationships with annual radiation, accumulated temperature and precipitation. We then determined grain yield stability for each of the three treatments.