MiR-216a-5p-containing exosomes suppress rTp17-induced inflammatory response by targeting TLR4.

Syphilis caused by () infection is accompanied by inflammatory injury of tissue, and has a worldwide distribution and increasing incidence over the past decade. Tp17 has been reported to be a strong membrane immunogen, and was initially observed to play a role in inflammation during syphilis, reacting intensely with human syphilitic sera. We therefore used recombinant Tp17 (rTp17) as a stimulator in our study.

Seroreactivity and immunogenicity of Tp0965, a hypothetical membrane protein of Treponema pallidum.

Background: Treponema pallidum (T. pallidum) subsp. pallidum is the causative agent of syphilis.

Acquired secondary syphilis in preschool children by nonsexual close contact.

Children may acquire syphilis as a consequence of nonsexual close contact if family members or caregivers are infected by active syphilis. We described 3 cases of acquired secondary syphilis in Chinese preschool children who contracted the disease from their caregivers to draw attention to the potential for syphilis patients to transmit Treponema pallidum to the children they are caretakers for.