[Effect of invisible appliance without bracket and self-locking bracket appliance on periodontal and subgingival flora in patients with periodontitis].

Purpose: To observe the effect of non-bracket invisible appliance and self-locking bracket appliance on periodontal health and subgingival flora in patients with periodontitis.

Methods: One hundred and ten patients with periodontitis who received orthodontic treatment were divided into invisible group and self-locking bracket group. The periodontal index including probing depth (PD), gingival index (GI), sulcular bleeding index (SBI) and plaque index (PLI) ，and the levels of inflammatory factors in the gingival crevicular fluid were examined.

Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature.

Chordoma is a sporadic type of cancer that affects the spine and is particularly challenging to treat due to the paucity of reported cases and scientific literature. In particular, primary chordomas affecting both the sacral and thoracic vertebrae are extremely rare. We herein report a rare case of chordoma in the sacral and thoracic vertebrae with pulmonary metastasis, along with a literature review.

1-[(6-Chloro-pyridin-3-yl)meth-yl]-10-nitro-1,2,3,5,6,7,8,9-octa-hydro-5,9-methano-imidazo[1,2-a]azocin-5-ol.

In the title compound, C16H19ClN4O3, the cyclo-hexane ring displays a chair formation and the tetra-hydro-pyridine ring displays an envelope conformation with the methyl-ene C atom as the flap; the imidazolidine ring also displays an envelope conformation with a methyl-ene C atom as the flap. In the crystal, O-H⋯N hydrogen bonds between hy-droxy groups and pyridine rings link inversion-related mol-ecules into dimers. Weak C-H⋯O hydrogen bonds further link the dimers into supra-molecular chains running along the c axis.

Preparation and evaluation of self-microemulsifying drug delivery system containing vinpocetine.

The main purpose of current investigation is to prepare a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability of vinpocetine, a poorly water-soluble drug. Suitable vehicles were screened by determining the solubility of vinpocetine in them. Certain surfactants were selected according to their emulsifying ability with different oils.