Publications by authors named "Shu-Rui Ke"
Article Synopsis
- Graves' disease (GD) can lead to Graves' Ophthalmopathy (GO), which risks irreversible damage to the eyes, but the exact cause is not fully understood.
- This study used single-cell analyses to track inflammation and immune cell changes in healthy individuals, GD patients, and those with GO at different stages, highlighting an overactive immune response and altered regulatory T cell functions.
- Key findings suggest that the dysfunction of these regulatory T cells is influenced by the YY1 protein and that understanding these immune changes can help identify new treatment targets for autoimmune diseases.
Article Synopsis
- The study investigates how corneal wound healing works by analyzing corneal limbal epithelial cell activities in cynomolgus monkeys through single-cell RNA sequencing.
- Researchers collected corneal limbal tissues at uninjured, 1-day, and 3-day healing stages to understand the transcriptional changes and cell migration involved in healing.
- The findings reveal nine distinct cell clusters, emphasizing the roles of different epithelial cells in healing, particularly highlighting the significance of transit amplifying cells in early healing through specific gene activation.