LncRNA FAISL Inhibits Calpain 2-Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer.

Triple negative breast cancer (TNBC) is the most aggressive subtype in breast tumors. When re-analyzing TCGA breast cancer dataset, we found cell adhesion molecules are highly enriched in differentially expressed genes in TNBC samples, among which Focal Adhesion Kinase (FAK) is most significantly associated with poor survival of TNBC patients. FAK is precisely modulated in the focal adhesion dynamics.

Calreticulin regulates hepatic stellate cell activation through modulating TGF-beta-induced Smad signaling.

Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM) as a wound healing process. Activated hepatic stellate cells (HpSCs) are the major producer of the ECM and play a central role in liver fibrogenesis. It has been widely accepted that elimination of activated HpSCs or reversion to a quiescent state can be a feasible strategy for resolving the disease, further highlighting the urgent need for novel therapeutic targets.

Photocatalytic cascade reactions and dye degradation over CdS-metal-organic framework hybrids.

Two bifunctional CdS-MOF composites have been designed and fabricated. The hybrids exhibited synergistic photocatalytic performance toward two cascade reactions under visible light integrating photooxidation activity of CdS and Lewis acids/bases of the MOF. The composite further promoted the photodegradation of dyes benefiting from effective electron transfer between the MOF and CdS.

A Giant 3d-4f Polyoxometalate Super-Tetrahedron with High Proton Conductivity.

The assembly of gigantic heterometallic metal clusters remains a great challenge for synthetic chemistry. Herein, based on the slow release strategy of lanthanide ions and in situ formation of lacunary polyoxometalates, two giant 3d-4f polyoxometalate inorganic clusters [LaNi W Sb P O (OH) ] (LaNi ) and [La Ni W Sb P O (OH) (H O) ] (La Ni ) are obtained. The nanoscopic inorganic cluster La Ni possesses a super tetrahedron structure, which can be viewed as assembly from four LaNi molecules encapsulating a central [La (SbO ) (H O) ] octahedron core.

Encapsulating Copper Nanocrystals into Metal-Organic Frameworks for Cascade Reactions by Photothermal Catalysis.

Composite materials with multifunctional properties usually possess synergetic effects in catalysis toward cascade reactions. In this work, a facile strategy to the encapsulation of octahedral Cu O nanocrystals (NCs) by metal-organic frameworks (MOFs) is reported, and an oriented growth of MOF enclosures (namely, HKUST-1) around Cu O NCs with desired feedstock ratio is achieved. The strategy defines the parameter range that precisely controls the etching rate of metal oxide and the MOF crystallization rate.

Decreased PEDF Promotes Hepatic Fatty Acid Uptake and Lipid Droplet Formation in the Pathogenesis of NAFLD.

Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver diseases worldwide, ranges from simple steatosis to steatohepatitis, with the risk for progressive fibrosis or even cirrhosis. While simple steatosis is a relatively benign condition, the buildup of toxic lipid metabolites can induce chronic inflammation, ultimately triggering disease progression. Pigment epithelium-derived factor (PEDF) is a secreted, multifunctional glycoprotein with lipid metabolic activities.

Encapsulating a Ni(II) molecular catalyst in photoactive metal-organic framework for highly efficient photoreduction of CO.

Photocatalytic reduction of CO to CO is a promising strategy for reducing atmospheric CO levels and storing solar radiation as chemical energy. Here, we demonstrate that a molecular catalyst [Ni(bpet)(HO)] successfully encapsulated into a highly robust and visible-light responsive metal-organic framework (Ru-UiO-67) to fabricate composite catalysts for photocatalytic CO reduction. The composite Ni@Ru-UiO-67 photocatalysts show efficient visible-light-driven CO reduction to CO with a TON of 581 and a selectivity of 99% after 20-h illumination, because of the facile electron transfer from Ru-photosensitizer to Ni(II) active sites in Ni@Ru-UiO-67 system.

Multiparametric radiomics improve prediction of lymph node metastasis of rectal cancer compared with conventional radiomics.

Aims: To establish multiparametric radiomics of rectal tumor for the preoperative prediction of lymph node (LN) metastasis.

Materials And Methods: This prospective study consisted of 115 consecutive patients with rectal carcinoma between April 2015 and April 2017. The multiparametric radiomics scores were extracted from the endorectal ultrasound (ERUS), computed tomography (CT) and shear-wave elastography (SWE) features of the rectal tumor, LN, and peripheral tissues.

Effect of different drying technologies on drying characteristics and quality of red pepper (Capsicum frutescens L.): a comparative study.

Background: Hot air drying and sun drying are traditional drying technologies widely used in the drying of agricultural products for a long time, but usually recognized as time-consuming or producing lower-quality products. Infrared drying is a rather effective drying technology that has advantages over traditional drying technologies. Thus, in order to investigate the application of infrared drying in the dehydration of red pepper, the drying characteristics and quality of infrared-dried red pepper were compared with those of sun-dried and hot air-dried red pepper.

Usefulness of Sonography in Evaluating Children Suspected of Malrotation: Comparison With an Upper Gastrointestinal Contrast Study.

Objectives: The purpose of this study was to prospectively evaluate the value of sonography in working up or ruling out malrotation by 3 sonographic features (inversion of the superior mesenteric artery and superior mesenteric vein, the whirlpool sign, and an intraperitoneal transverse duodenum) and comparing it with an upper gastrointestinal (GI) contrast study.

Methods: A total of 70 pediatric patients who underwent detailed abdominal sonography to rule out intestinal malrotation were included. Twenty-three of them also underwent an upper GI contrast study.

Multiparametric 3-T MRI for differentiating low-versus high-grade and category T1 versus T2 bladder urothelial carcinoma.

OBJECTIVE. The purpose of this study was to determine an optimal multiparametric MRI protocol for characterizing tumors of low versus high grade and differentiating tumors as T1 versus T2 for preoperative staging of bladder urothelial carcinoma. SUBJECTS AND METHODS.

[Appearance and clinical value of MRI in sinonasal embryonal rhabdomyosarcoma].

Objective: To investigate the appearance and clinical value of MRI in the diagnosis of embryonal rhabdomyosarcoma in nasal cavity and paranasal sinuses.

Methods: The clinical, pathological and MRI findings of five patients with pathology proved embryonal rhabdomyosarcoma in nasal cavity and paranasal sinuses were retrospectively analyzed.

Results: The major clinical symptoms included nasal obstruction (4 cases), exophthalmus (4 cases), decreased eyesight (2 cases), epistaxis (1 case), decreased olfactory sensation (1 case) and restriction of eyeball movement (1 case).

[Clinical observation on acupuncture for treatment of paralytic strabismus].

Objective: To compare therapeutic effects of acupuncture at local points of eye and western medicine on paralytic strabismus.

Methods: One hundred cases were randomly divided into an acupuncture group and a medication group. The acupuncture group (58 cases) was treated with acupuncture at local points of eye, Jingming (BL 1), Tongziliao (GB 1), Shangming (Extra) etc.

[The quantified analysis of fresh mutton tenderness using PLS methods and Fourier transform near-infrared spectroscopy].

Ninety eight representative fresh mutton samples from Neimeng, Ningxia, Gansu, Xinjiang province were selected for this study, the nondestructive measurement of the fresh mutton tenderness by Fourier transform near infrared (FT-NIR) spectroscopy was discussed. Partial least squares(PLS) algorithm was used to build the model between the shear force value of the fresh mutton tenderness measured by the texture machine and the FT-NIR spectra. The influence of different processing method of spectra, factors and wave regions on the determination coefficients (r2), root mean square error of cross validation (RMSECV) and root mean square error of prediction (RMSEP) was studied.

[The functional mechanism of CIK cells on ovarian carcinoma cell lines SKOV3/CDDP].

Aim: To investigate the functional mechanism of CIK cells or ovarian carcinoma cell lines SKOV3/CDDP.

Methods: The changes of ultramicrostructure, cell cycle, apoptosis, expression of multidrug resistance-associated protein (MDR1, Topo-IIbeta) and other molecules (hB7-1, hB7-2, MHCIb, HLA-DR) of SKOV3/CDDP cells treated with or without CIK cells were detected by electron microscope, MTT and FCM. The changes of cytokine (IL-2, TNF-alpha, IFN-gamma, GM-CSF) in sera of SCID mice bearing SKOV3/CDDP cells were detected by radioimmunit and ELISA.

Morphological changes of cholinergic nerve fibers in the urinary bladder after establishment of artificial somatic-autonomic reflex arc in rats.

Objective: To establish an artificial somatic-autonomic reflex arc in rats and observe the following distributive changes of neural fibers in the bladder.

Methods: Adult Sprague-Dawley rats were randomly divided into three groups: control group, spinal cord injury (SCI) group, and reinnervation group. DiI retrograde tracing was used to verify establishment of the model and to investigate the transport function of the regenerated efferent axons in the new reflex arc.

Poly-lactic acid and agarose gelatin play an active role in the recovery of spinal cord injury.

Objective To investigate the role of poly-lactic acid and agarose gelatin in promoting the functional recovery of the injured spinal cord. Methods Poly-lactic acid (PLA) or agarose was embedded in the space between two stumps of the hemisectioned spinal cord. Immunohistochemistry was used to show astroglia proliferation and the infiltration of RhoA-positive cells.

[Survey on prevalence of 1 526 children with sleep disturbances in age of 2 to 12 years old in Chengdu].

Objective: To find out the prevalence of sleep disturbances for children aged 2 to 12 years old in Chengdu.

Methods: Totally 1 600 children aged 2-12 years old were selected from 5 districts in Chengdu and investigated by using questionnaire.

Results: All 1 526 survey papers were returned.