Publications by authors named "Shu-Qiang Fan"
Heparin affects both dermal fibroblast proliferation and collagen and may mediate these effects by altering the levels of transforming growth factor-beta1 (TGF-beta1) production and TGF-beta1 mRNA expression as a wound healing modulator. The purpose of this study is to probe the effect of heparin on TGF-beta1 and TGF-beta1 mRNA production by human normal skin and hyperplastic scar fibroblasts. This research investigates the effect of heparin on TGF-beta1 and TGF-beta1 mRNA production by human normal skin and hyperplastic scar fibroblasts with exposure to 0 microg/mL, 100 microg/mL, 300 microg/mL, or 600 microg/mL heparin for 24, 48, 72, or 96 hours in a serum-free in vitro model.
View Article and Find Full Text PDFHeparin affects both dermal fibroblast proliferation and collagen and may mediate these effects by altering the levels of basic fibroblast growth factor (bFGF) and transforming growth factor-beta1 (TGF-beta1) production as a wound healing modulator. The purpose of this study is to probe the effect of heparin on bFGF and TGF-beta1 production by human normal skin and hyperplastic scar fibroblasts. This research investigates the effect of heparin on bFGF and TGF-beta1 production by human normal skin and hyperplastic scar fibroblasts with exposure to 0, 100, 300, or 600 microg/ml heparin for 24, 48, 72, or 96 hours in a serum-free in vitro model.
View Article and Find Full Text PDF[Study on poly A site gene mutation of transforming growth factor-beta1 receptor type II between multiple and single site keloid].
Zhonghua Zheng Xing Wai Ke Za Zhi
January 2006
Article Synopsis
- - The study aimed to explore the differences in the development of multiple and single site keloids by analyzing mutations in the Poly A site of the TbetaR II gene.
- - Researchers collected 20 keloid samples (6 from multiple sites and 14 from single sites), extracted DNA, and used PCR and sequencing techniques to identify mutations.
- - Results showed that the mutation rate at the Poly A site was significantly higher in multiple site keloids (50%) compared to single site keloids (7.1%), suggesting differing underlying mechanisms for the two types.