Maternal nicotine exposure aggravates metabolic associated fatty liver disease via PI3K/Akt signaling in adult offspring mice.

Aim: The aim of this study is to investigate the effect of maternal nicotine exposure (MNE) on the development of metabolic associated fatty liver disease (MAFLD) in adulthood offspring and the underlying mechanism.

Methods: Pregnant mice (n = 22) were subcutaneously injected with either saline vehicle (n = 11) or nicotine (n = 11) twice a day on gestational days 11-21. Offspring mice (n = 176) from both groups were weaned at postnatal day 21, and for 6 months after postnatal day 21, 96 mice were fed either a standard chow diet (n = 48) or a high-fat diet (n = 48).

Prenatal Evaluation for Detection of Anorectal Atresia: Value of Ultrasound.

Objectives: To investigate the applicability and value of ultrasound (US) in the diagnosis of anorectal atresia.

Methods: Between January 2008 and January 2016, we prospectively evaluated 63,101 fetuses (gestational age, 20-38 weeks), including low- and high-risk populations using 2-dimensional US scans. An abnormal imaging finding was defined as an anal canal diameter of less than the 95% confidence interval (small anal canal) of the normal range or the absence of an anal canal and rectum.

[Impact of mobile phone radiation on the quality and DNA methylation of human sperm in vitro].

Objective: To investigate the influences of mobile phone radiation on the quality and DNA methylation of human sperm in vitro.

Methods: According to the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, we randomly selected 97 male volunteers with normal semen parameters and divided each semen sample from the subjects into two equal parts, one exposed to mobile phone radiation at 1950 M Hz, SAR3. 0 W/kg for 3 hours while the other left untreated as the control.

[Heritability of body weight and fork length for Oncorhynchus masou masou].

Body weight and body length have been considered as the most important production traits for the fish genetic improvement. For cold-water fish, body length was usually substituted by fork length. In order to estimate the heritability of body weight and fork length of the sixth generation Oncorhynchus masou masou, which was introduced into China, the method of unbalanced nest design and an artificial insemination technigue were used.

Sonographic evaluation of the development of the fetal rectum and anal canal.

Purpose: To describe the sonographic (US) appearance of fetal anal canal and rectum and establish nomograms of their normal measurements.

Methods: This was a prospective, cross-sectional study of 524 healthy women (mean age, 27 years; range, 21-37 years) with normal singleton pregnancy between 18 and 40 weeks of gestational age (GA). High-resolution transabdominal US was used to visualize and measure the normal fetal anal canal and rectum.

[Experimental study on early escharectomy after major burns in minipigs].

Objective: To investigate optimal time for early escharectomy after severe scald in minipigs.

Methods: Minipigs inflicted with 35% TBSA full thickness burn were employed in the study, and they were randomly divided into A (n = 7, with escharectomy at 6PSH), and B (n = 7, with escharectomy at 24 PSH) groups. The hemodynamics indices, hemorrheology, and the serum levels of cytokines in the two groups were determined before burns and at 6, 8, 16, 24 and 72PSH.